INT95792

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.98
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SSTR1) cell-cell signaling (SSTR1) signal transducer activity (SSTR1)
Anatomy Link Frequency
nociceptors 2
spinal cord 1
SSTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 15 100.00 Very High Very High Very High
nociceptor 18 99.36 Very High Very High Very High
Spinal cord 2 97.24 Very High Very High Very High
opioid receptor 2 96.24 Very High Very High Very High
Endogenous opioid 2 92.36 High High
Dorsal horn 2 91.40 High High
narcan 4 90.92 High High
antagonist 5 90.56 High High
Opioid 2 90.12 High High
Lasting pain 2 89.76 High High
Disease Link Frequency Relevance Heat
Adenoma 26 99.28 Very High Very High Very High
Nociception 11 98.68 Very High Very High Very High
Pain 2 89.76 High High
Cancer 77 89.44 High High
Ganglion Cysts 2 84.56 Quite High
Hyperalgesia 8 79.04 Quite High
INFLAMMATION 5 75.00 Quite High
Calcification 1 66.00 Quite High
Fibrosis 1 65.28 Quite High
Vomiting 1 44.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goal of the present study is to show that cutaneous nociceptors are under the tonic inhibitory control of SRIF.
Regulation (control) of SRIF in nociceptors associated with nociceptor
1) Confidence 0.57 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356891 Disease Relevance 0.57 Pain Relevance 0.60
These findings demonstrate that SRIF receptors maintain a tonic inhibitory control over peripheral nociceptors, and this may contribute to mechanisms that control the excitability of these terminals.
Regulation (control) of SRIF in nociceptors associated with nociceptor
2) Confidence 0.42 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356891 Disease Relevance 0.22 Pain Relevance 1.04
Our previous results have shown that somatostatin receptor subtype SST(2A) is responsible for thermal, but not mechanical nociceptive transmission in the rat spinal cord.
Neg (not) Regulation (responsible) of somatostatin receptor in spinal cord associated with nociception, somatostatin and spinal cord
3) Confidence 0.02 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18452056 Disease Relevance 0.46 Pain Relevance 0.46
A drawback of this method is that the small structural modification may affect the somatostatin receptor binding affinity [52].
Spec (may) Regulation (affect) of somatostatin receptor associated with somatostatin
4) Confidence 0.01 Published 2007 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1914264 Disease Relevance 0.08 Pain Relevance 0.09
Membranous somatostatin receptor (SSTR)-2A immunoreactivity was found in 89% STAs and 94% FTSHomas, whereas SSTR5 was positive in 78% of both STAs and FTSHomas.
Regulation (immunoreactivity) of somatostatin receptor associated with adenoma and somatostatin
5) Confidence 0.01 Published 2009 Journal Endocr. Pathol. Section Abstract Doc Link 19774499 Disease Relevance 1.65 Pain Relevance 0.08

General Comments

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