INT95794

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.57
Pain Relevance 9.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (GRHL3) DNA binding (GRHL3)
Anatomy Link Frequency
dorsal horn 2
superior 1
arm 1
central nervous system 1
GRHL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 51 100.00 Very High Very High Very High
dorsal root ganglion 13 100.00 Very High Very High Very High
spinal dorsal horn 8 100.00 Very High Very High Very High
Piles 7 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Inflammation 10 99.44 Very High Very High Very High
electroacupuncture 28 99.42 Very High Very High Very High
Eae 12 99.36 Very High Very High Very High
Central nervous system 2 99.36 Very High Very High Very High
Neuropathic pain 20 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 17 100.00 Very High Very High Very High
Anorectal Disorders 7 100.00 Very High Very High Very High
Nociception 5 99.48 Very High Very High Very High
INFLAMMATION 6 99.44 Very High Very High Very High
Injury 15 99.36 Very High Very High Very High
Neuropathic Pain 20 99.12 Very High Very High Very High
Pain 33 94.00 High High
Reprotox - General 3 1 79.60 Quite High
Fecal Incontinence 1 55.44 Quite High
Diarrhoea 12 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs.
Gene_expression (produced) of SOM in central nervous system associated with somatostatin and central nervous system
1) Confidence 0.68 Published 2003 Journal Curr Opin Pharmacol Section Abstract Doc Link 12550740 Disease Relevance 0.16 Pain Relevance 0.68
In a dose-dependent manner, intraplantar injection of the SRIF receptor antagonist cyclo-somatostatin (c-SOM) results in nociceptive behaviors in normal animals and enhancement of nociceptive behaviors in formalin-injected animals, and these actions can be blocked when c-SOM is coapplied with three different SRIF agonists.
Gene_expression (injection) of SOM associated with nociception, antagonist, agonist and somatostatin
2) Confidence 0.65 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356891 Disease Relevance 0.60 Pain Relevance 0.81
The other LENT/SOM proctitis symptoms were also more frequently reported in the escalated arm at all severities; this difference was statistically significant for grade ?
Gene_expression (proctitis) of SOM in arm associated with piles
3) Confidence 0.65 Published 2010 Journal International Journal of Radiation Oncology, Biology, Physics Section Body Doc Link PMC2937212 Disease Relevance 0.65 Pain Relevance 0.51
However, EA could significantly enhance SOM expression in dorsal root ganglion (DRG) and spinal dorsal horn as well as ppSOM mRNA level in DRG of neuropathic pain rats.
Gene_expression (expression) of SOM in dorsal horn associated with ganglion cysts, dorsal root ganglion, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
4) Confidence 0.49 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15970377 Disease Relevance 0.92 Pain Relevance 1.68
The expression of SOM in sensory neurones can be modulated by the trophic factor glial-cell-line-derived neurotrophic factor (GDNF).
Gene_expression (expression) of SOM associated with somatostatin
5) Confidence 0.46 Published 2003 Journal Curr Opin Pharmacol Section Abstract Doc Link 12550740 Disease Relevance 0.19 Pain Relevance 0.84
No significant change was detected in the expression of SOM and ppSOM mRNA following CCI.
Gene_expression (expression) of ppSOM associated with eae and somatostatin
6) Confidence 0.42 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15970377 Disease Relevance 0.90 Pain Relevance 1.67
However, EA could significantly enhance SOM expression in dorsal root ganglion (DRG) and spinal dorsal horn as well as ppSOM mRNA level in DRG of neuropathic pain rats.
Gene_expression (expression) of ppSOM in dorsal horn associated with ganglion cysts, dorsal root ganglion, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
7) Confidence 0.42 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15970377 Disease Relevance 0.93 Pain Relevance 1.71
No significant change was detected in the expression of SOM and ppSOM mRNA following CCI.
Gene_expression (expression) of SOM associated with eae and somatostatin
8) Confidence 0.42 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15970377 Disease Relevance 0.89 Pain Relevance 1.66
Studies suggest that more easily measurable criteria such as elevated liver enzyme levels and biliary dilatation are superior in predicting a response to sphincter ablation.[39]Studies have also suggested that SOM may be highly sensitive for diagnosing SOD but may lack specificity.[38]


Gene_expression (sensitive) of SOM in superior
9) Confidence 0.33 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702883 Disease Relevance 0.33 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox