INT95799

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.95
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NTRK2) plasma membrane (NTRK2)
Anatomy Link Frequency
dorsal horn 1
hippocampus 1
NTRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 3 99.96 Very High Very High Very High
Dorsal horn 4 99.28 Very High Very High Very High
bDMF 21 99.04 Very High Very High Very High
Pain 100 98.20 Very High Very High Very High
long-term potentiation 3 98.20 Very High Very High Very High
Nerve growth factor 37 97.64 Very High Very High Very High
depression 4 88.96 High High
tetrodotoxin 8 86.76 High High
metalloproteinase 1 84.08 Quite High
Osteoarthritis 45 77.44 Quite High
Disease Link Frequency Relevance Heat
Pain 132 98.20 Very High Very High Very High
Death 3 94.16 High High
Disease 134 92.68 High High
Depression 3 88.96 High High
Stress 58 86.00 High High
Nervous System Malformation 1 85.32 High High
Frailty 48 77.44 Quite High
Apoptosis 1 70.96 Quite High
Colon Cancer 2 68.24 Quite High
INFLAMMATION 46 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the Schaffer collateral pathway of the hippocampus, binding of BDNF to high-affinity trkB receptors is essential for the induction of long-term potentiation, a specific type of synaptic plasticity.
trkB Binding (binding) of in hippocampus associated with long-term potentiation and hippocampus
1) Confidence 0.35 Published 2003 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 12628355 Disease Relevance 0.17 Pain Relevance 0.44
However, the consequences of BDNF binding to trkB receptors in the dorsal horn in relation to pain mechanisms are less well established and are considered in detail.
trkB Binding (binding) of in dorsal horn associated with pain and dorsal horn
2) Confidence 0.35 Published 2003 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 12628355 Disease Relevance 0.26 Pain Relevance 0.45
Therefore, due to an increased level of PAI-1, mature BDNF could not be produced, which in turn could not bind to TrkB.
TrkB Neg (not) Binding (bind) of associated with bdmf
3) Confidence 0.32 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.72 Pain Relevance 0.59
NT3 also binds with TrkA and TrkB.
TrkB Binding (binds) of
4) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.12 Pain Relevance 0.78
Levocabastine, which has affinity for the NT2 receptor, did not inhibit specific binding of (125)I-NT in membrane competition or autoradiographic studies.
NT2 receptor Binding (affinity) of
5) Confidence 0.10 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356931 Disease Relevance 0.07 Pain Relevance 0.08
The lack of inhibition by levocabastine suggests that the second binding site detected does not correspond to the NT2 receptor.
NT2 receptor Neg (not) Binding (correspond) of
6) Confidence 0.07 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356931 Disease Relevance 0 Pain Relevance 0.09
While proBDNF binds only to p75 receptor, mature BDNF displays high affinity to TrkB and lower affinity to p75 [61].
TrkB Binding (affinity) of
7) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.62 Pain Relevance 0.04
Slides were then incubated for 1 hour with rabbit antibody to tyrosine kinase receptor B (BDNF receptor, batch number Rb68-010906-WS; Biosensis, Flagstaff Hill, Australia) at a 1:500 dilution.
kinase receptor B Binding (tyrosine) of
8) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0

General Comments

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