INT958

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.92
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (ATRX) nucleus (ATRX) helicase activity (ATRX)
DNA binding (ATRX)
ATRX (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 9 100.00 Very High Very High Very High
corticosteroid 2 99.24 Very High Very High Very High
Dopamine 4 99.20 Very High Very High Very High
Pain 4 98.14 Very High Very High Very High
Central nervous system 5 95.36 Very High Very High Very High
Clonidine 2 86.24 High High
primary somatosensory cortex 1 61.72 Quite High
central sensitization 1 55.56 Quite High
c fibre 1 52.92 Quite High
Inflammation 2 47.12 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 16 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 9 100.00 Very High Very High Very High
Injury 2 99.98 Very High Very High Very High
Pressure And Volume Under Development 9 98.60 Very High Very High Very High
Pain 2 98.14 Very High Very High Very High
Disease 3 90.20 High High
Stroke 7 78.60 Quite High
Lymphedema 1 71.36 Quite High
Cancer 15 64.32 Quite High
Hypercalcemia 7 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In any case there is little evidence that supports the efficacy of the interventions normally used to treat or prevent CRPS-SHS.
Negative_regulation (prevent) of SHS associated with reflex sympathetic dystrophy and syndrome
1) Confidence 0.58 Published 2005 Journal Eura Medicophys Section Abstract Doc Link 16474282 Disease Relevance 0.95 Pain Relevance 0.59
These studies investigated continuous passive motion and neuromuscular stimulation in hand oedema as well as oral corticosteroids, intramuscular calcitonin and trauma prevention in SHS.
Negative_regulation (prevention) of SHS associated with pressure and volume under development, corticosteroid, syndrome and injury
2) Confidence 0.37 Published 2000 Journal Scand J Rehabil Med Section Abstract Doc Link 10782934 Disease Relevance 1.59 Pain Relevance 0.16
Results showed that low subjective health status was related to sex, age and perceived working situation: for each of the six areas of the NHP (pain, physical mobility, energy, sleep, social isolation, emotional reactions) there was a lower SHS for women and a decrease with age for both sexes.
Negative_regulation (decrease) of SHS associated with pain
3) Confidence 0.37 Published 1995 Journal Rev Epidemiol Sante Publique Section Abstract Doc Link 7784675 Disease Relevance 0.10 Pain Relevance 0.10
Methysergide, cyrpoheptadine, and p-chlorophenylalanine given intracerebroventricularly (ICV) or systemically significantly blocked SHS behavior induced by 10 mg/kg MA.
Negative_regulation (blocked) of SHS
4) Confidence 0.33 Published 1979 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 117484 Disease Relevance 0 Pain Relevance 0.14
Some neuroleptics inhibited SHS as well as SG behaviors, but the older of inhibitory activity of neuroleptics onSHS behavior was quite different from their effects on SG behaviors induced by MA or apomorphine.
Negative_regulation (inhibited) of SHS
5) Confidence 0.28 Published 1979 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 117484 Disease Relevance 0 Pain Relevance 0.26
The first one includes pyrophosphate-resembling bisphosphonates, such as clodronate and etidronate, which are metabolically incorporated into nonhydrolyzable ATP analogues that act as inhibitors of ATP-dependent enzymes [14].
Negative_regulation (inhibitors) of ATP-dependent
6) Confidence 0.00 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0.28 Pain Relevance 0

General Comments

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