INT95800

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
afferent neurons 2
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 15 99.96 Very High Very High Very High
qutenza 52 98.60 Very High Very High Very High
antagonist 4 95.16 Very High Very High Very High
withdrawal 5 92.44 High High
Inflammatory mediators 3 92.40 High High
IPN 4 86.00 High High
Deafferentation 2 79.76 Quite High
Inflammation 18 70.72 Quite High
dorsal root ganglion 27 67.28 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 18 99.96 Very High Very High Very High
INFLAMMATION 23 92.40 High High
Targeted Disruption 4 92.36 High High
Hypersensitivity 1 88.48 High High
Inflammatory Pain 4 86.00 High High
Ganglion Cysts 27 67.28 Quite High
Nociception 11 50.00 Quite Low
Pain 8 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present findings confirmed a role for endogenous PGE2 produced by COX-1 in adaptive gastric cytoprotection and suggested that this action is mediated by activation of EP1-receptors but not associated with capsaicin-sensitive afferent neurons.
Positive_regulation (mediated) of Positive_regulation (activation) of EP1 in afferent neurons associated with qutenza
1) Confidence 0.43 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356942 Disease Relevance 0.25 Pain Relevance 0.28
These results suggest that a PKC-dependent pathway downstream of EP1 activation is mainly involved in PGE2-induced thermal hyperalgesia.
Positive_regulation (induced) of Positive_regulation (activation) of EP1 associated with thermal hyperalgesia
2) Confidence 0.36 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.98 Pain Relevance 0.87

General Comments

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