INT95808

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.84
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
hepatocytes 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 3 100.00 Very High Very High Very High
aspirin 3 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
lidocaine 2 99.98 Very High Very High Very High
cINOD 6 99.84 Very High Very High Very High
Inflammation 16 99.66 Very High Very High Very High
Pain 10 99.66 Very High Very High Very High
Inflammatory response 3 98.40 Very High Very High Very High
cytokine 1 96.76 Very High Very High Very High
antagonist 2 92.96 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 10 99.86 Very High Very High Very High
Pain 6 99.60 Very High Very High Very High
INFLAMMATION 19 98.04 Very High Very High Very High
Toxicity 2 97.52 Very High Very High Very High
Hepatocellular Cancer 1 91.40 High High
Stress 5 84.76 Quite High
Disease 2 84.72 Quite High
Repression 2 78.76 Quite High
Apoptosis 1 55.16 Quite High
Sepsis 2 44.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, increased Nrf2 caused by Keap1 depletion was reversed by co-depletion of NF-kappaB.
Negative_regulation (reversed) of Negative_regulation (depletion) of NF-kappaB
1) Confidence 0.41 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.40 Pain Relevance 0.10
In support of this concept, we found, using inhibitors of Jun kinase and NF-kappaB p50 nuclear localization, that COX-2 gene transcription was completely dependent on phospho-c-Jun plus p50 at 6 h after LPS treatment but was only partially dependent on the combination of these factors at later treatment times.
Negative_regulation (using) of Negative_regulation (inhibitors) of p50
2) Confidence 0.33 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.31 Pain Relevance 0.12
In support of this concept, we found, using inhibitors of Jun kinase and NF-kappaB p50 nuclear localization, that COX-2 gene transcription was completely dependent on phospho-c-Jun plus p50 at 6 h after LPS treatment but was only partially dependent on the combination of these factors at later treatment times.
Negative_regulation (using) of Negative_regulation (inhibitors) of NF-kappaB
3) Confidence 0.33 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.31 Pain Relevance 0.12
Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice.
Negative_regulation (decreases) of Negative_regulation (inhibition) of nuclear factor-kappa B associated with pain and inflammation
4) Confidence 0.33 Published 2007 Journal Neuroreport Section Title Doc Link 17426605 Disease Relevance 0.61 Pain Relevance 0.57
We sought to determine if glial nuclear factor kappaB inhibition decreases formalin pain.
Negative_regulation (decreases) of Negative_regulation (inhibition) of nuclear factor kappaB associated with pain
5) Confidence 0.33 Published 2007 Journal Neuroreport Section Abstract Doc Link 17426605 Disease Relevance 0.59 Pain Relevance 0.31
Absence of nuclear factor kappaB inhibition by NSAIDs in hepatocytes.
Negative_regulation (Absence) of Negative_regulation (inhibition) of nuclear factor kappaB in hepatocytes associated with aspirin and cinod
6) Confidence 0.14 Published 2002 Journal Hepatology Section Title Doc Link 11826407 Disease Relevance 0.45 Pain Relevance 0.63
The mechanistic studies showed that CAPZ inhibited the expression of iNOS mRNA through the inactivation of nuclear transcription factor-kappa B (NF-kappa B).
Negative_regulation (inhibited) of Negative_regulation (inactivation) of NF-kappa B
7) Confidence 0.06 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11357890 Disease Relevance 0.17 Pain Relevance 0.30
Lidocaine inhibits epithelial chemokine secretion via inhibition of nuclear factor kappa B activation.
Negative_regulation (inhibits) of Negative_regulation (inhibition) of nuclear factor kappa B associated with chemokine and lidocaine
8) Confidence 0.03 Published 2010 Journal Immunobiology Section Title Doc Link 19559500 Disease Relevance 0 Pain Relevance 0.30

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