INT95872

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Context Info
Confidence 0.74
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.75
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
P19 1
hepatocyte 1
colon 1
stem cell 1
neurites 1
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 2 97.24 Very High Very High Very High
Central nervous system 2 81.92 Quite High
cINOD 4 80.08 Quite High
COX-2 inhibitor 1 76.00 Quite High
Inflammation 22 47.84 Quite Low
cytokine 8 37.48 Quite Low
Paracetamol 1 25.00 Low Low
withdrawal 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 3 99.84 Very High Very High Very High
Cancer 75 99.68 Very High Very High Very High
Liver Cancer 1 99.16 Very High Very High Very High
Neuritis 2 97.24 Very High Very High Very High
Alagille Syndrome 44 93.92 High High
Colon Cancer 11 93.92 High High
Stomach Cancer 44 92.32 High High
Adenoma 2 89.08 High High
Targeted Disruption 68 87.20 High High
Skin Cancer 2 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, immunostaining data showed that beta-catenin was translocalized into nuclei after retinoic acid induced P19 cell aggregates were trypsinized and cultured in serum free N2 medium for 2 and 4 d.
Localization (translocalized) of beta-catenin in P19
1) Confidence 0.74 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367680 Disease Relevance 0.07 Pain Relevance 0.10
The presence of genetic alterations resulting in constitutive beta-catenin stabilization in human and murine liver tumors also implicates this pathway in hepatocyte proliferation.
Localization (stabilization) of beta-catenin in hepatocyte associated with liver cancer
2) Confidence 0.73 Published 2006 Journal Hepatology Section Abstract Doc Link 16557553 Disease Relevance 0.38 Pain Relevance 0
Because Kato-III cells have a multicopy of the wild-type CTNNB1 (Suriano et al, 2005), TNF-?
Localization (Because) of CTNNB1
3) Confidence 0.65 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.53 Pain Relevance 0
-catenin expressed from retained intact CTNNB1, which contributes to the promotion of the total Wnt/?
Localization (retained) of CTNNB1
4) Confidence 0.65 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.60 Pain Relevance 0
Meanwhile, the distribution of beta-catenin on the neurites indicates that this protein may also be involved in neuritis outgrowth process.
Localization (distribution) of beta-catenin in neurites associated with neuritis
5) Confidence 0.65 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367680 Disease Relevance 0.17 Pain Relevance 0.13
Importantly, mPGES-1 deletion also blocked the nuclear accumulation of beta-catenin in ACF, confirming that beta-catenin is a critical target of PGE(2) procarcinogenic signaling in the colon.
Localization (accumulation) of beta-catenin in colon associated with aberrant crypt foci
6) Confidence 0.37 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.90 Pain Relevance 0.17
Wnt is a secreted morphogen that initiates a signaling cascade leading to stabilization of beta-catenin, a protein that transactivates promoters bound by the transcription factors TCF or LEF1 [44].
Localization (stabilization) of beta-catenin
7) Confidence 0.16 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0
For example, by stabilizing the transcriptional activator beta-catenin, secreted Wnt glycoproteins transduce signals that are required for hair follicle development and differentiation, stem cell activation and stem cell maintenance [12–15].
Localization (secreted) of beta-catenin in stem cell
8) Confidence 0.15 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0

General Comments

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