INT95895

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Context Info
Confidence 0.18
First Reported 2001
Last Reported 2001
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) endoplasmic reticulum (Sigmar1)
extracellular space (Npy) extracellular region (Npy) lipid particle (Sigmar1)
Anatomy Link Frequency
cerebellum 3
hippocampus 1
Sigmar1 (Rattus norvegicus)
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 98.20 Very High Very High Very High
Hippocampus 4 89.60 High High
agonist 2 79.56 Quite High
Neuropeptide 4 75.00 Quite High
Analgesic 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since no significant effects by sigma-receptor ligands on NPY-induced G-protein activation were observed, we did not see an inverse agonism of NPY and sigma-receptor ligands at the putative NPY/sigma receptor measured at the level of G-protein activation, suggesting that sigma receptors and NPY receptors do not represent a common population in rat hippocampus and cerebellum.
sigma-receptor Neg (no) Regulation (effects) of Positive_regulation (activation) of NPY-induced in cerebellum associated with hippocampus
1) Confidence 0.18 Published 2001 Journal Brain Res. Section Abstract Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.28
Since no significant effects by sigma-receptor ligands on NPY-induced G-protein activation were observed, we did not see an inverse agonism of NPY and sigma-receptor ligands at the putative NPY/sigma receptor measured at the level of G-protein activation, suggesting that sigma receptors and NPY receptors do not represent a common population in rat hippocampus and cerebellum.
sigma-receptor Neg (no) Regulation (effects) of in hippocampus Positive_regulation (activation) of NPY-induced in cerebellum associated with hippocampus
2) Confidence 0.06 Published 2001 Journal Brain Res. Section Abstract Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.28

General Comments

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