INT95898

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 10.51
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (CAPG) nucleus (CAPG) protein complex assembly (CAPG)
cytoplasm (CAPG)
Anatomy Link Frequency
astrocytes 3
monocyte 2
joints 1
eyes 1
macrophage 1
CAPG (Homo sapiens)
Pain Link Frequency Relevance Heat
Percutaneous transluminal coronary angioplasty 11 99.64 Very High Very High Very High
Inflammation 109 99.52 Very High Very High Very High
Arthritis 187 99.16 Very High Very High Very High
Clonidine 1 98.24 Very High Very High Very High
rheumatoid arthritis 54 97.44 Very High Very High Very High
Inflammatory mediators 2 96.64 Very High Very High Very High
lidocaine 6 92.08 High High
Angina 1 86.72 High High
imagery 101 86.00 High High
cytokine 61 84.96 Quite High
Disease Link Frequency Relevance Heat
Hemolytic Uremic Syndrome 54 99.92 Very High Very High Very High
INFLAMMATION 118 99.52 Very High Very High Very High
Glaucoma 275 99.16 Very High Very High Very High
Rheumatoid Arthritis 131 99.16 Very High Very High Very High
Pressure And Volume Under Development 36 98.52 Very High Very High Very High
Infection 17 98.12 Very High Very High Very High
Juvenile Chronic Polyarthritis 24 97.20 Very High Very High Very High
Disease 267 97.00 Very High Very High Very High
Ganglion Cysts 69 96.80 Very High Very High Very High
Recurrence 317 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 2nd-5th MCP region was treated as a single ROI because the MCP joints are in juxtaposition to each other, and, in the case in which an MCP is swollen, it is impossible to determine where one MCP region ends and the adjacent one begins.
Gene_expression (region) of MCP in joints
1) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374475 Disease Relevance 0 Pain Relevance 0
A known volume of clay was applied to the wrist or MCP region either in a lump, to simulate focal swelling, or spread over a large area, to simulate diffuse swelling (Figure 2a).
Gene_expression (region) of MCP in wrist associated with pressure and volume under development
2) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374475 Disease Relevance 0.58 Pain Relevance 0.31
Further, increased expression of capping protein G (CAPG) was shown previously by microarray and Western blot in purified human optic nerve head astrocytes from glaucomatous donors [11].
Gene_expression (expression) of CAPG in astrocytes
3) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.96 Pain Relevance 0.04
qRT-PCR was used to examine the expression of GPNMB, RBP1, CAPG, APOE, TGFBI, and TIMP1, which were identified in the nonhuman primate model, in immuno-enriched optic nerve head astrocytes from glaucomatous Caucasian American donors [see Additional file 7 and Additional file 8].
Spec (examine) Gene_expression (expression) of CAPG in astrocytes
4) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.54 Pain Relevance 0
Differential expression of motility genes, including capping protein G (CAPG) and transforming growth factor beta-induced (TGFBI), was consistent with the reactive, migratory astrocyte phenotype characteristic of glaucoma [12], as were ECM remodeling genes, such as GPNMB [79,80] and TIMP1 [81,82].
Gene_expression (expression) of CAPG in astrocyte associated with glaucoma
5) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.40 Pain Relevance 0
Increased levels of monocyte chemoattractant protein (MCP)-1 have been reported in several inflammatory disorders.
Gene_expression (levels) of MCP in monocyte associated with inflammation
6) Confidence 0.24 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.33 Pain Relevance 0.54
NHE inhibition using amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, and 5-(N-methyl-N-isobutyl)amiloride as well as the non-amiloride NHE inhibitors cimetidine, clonidine, and harmaline suppressed endotoxin-induced IL-8 and monocyte chemoattractant protein (MCP)-1 production by human umbilical endothelial vein cells (HUVECs).
Gene_expression (production) of MCP in vein associated with clonidine
7) Confidence 0.21 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.46 Pain Relevance 0.32
-dependent expression of the CXCL5, CYP3A4, LAMR1, MCP, and PSMB9 genes, as noted here, has been previously described [35-40].
Gene_expression (expression) of MCP
8) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779405 Disease Relevance 0.28 Pain Relevance 0.09
Patients with atypical HUS should, therefore, undergo complement factor determination (C3, factor H, factor I, factor B, and MCP expression), genotyping (factor H, factor H-linked genes, factor I, MCP, factor B and C3) and determination of anti-factor H antibodies prior to renal Tx so that the risk of graft failure can be evaluated [6].
Gene_expression (expression) of MCP associated with hemolytic uremic syndrome
9) Confidence 0.04 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 1.78 Pain Relevance 0
Membrane-bound CRegs such as MCP, DAF, Crry (Fig. 2a), and CD59 (Fig. 2b) are expressed in the different layers of the cornea to protect this tissue from complement-mediated damage [27, 33, 50].
Gene_expression (expressed) of MCP in cornea
10) Confidence 0.04 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.59 Pain Relevance 0.05
Synovial blood flow was evaluated by PDUS at the metacarpophalangeal (MCP) joints and both wrists (24 RA patients) and knee joints (20 patients, 22 knees) in longitudinal and transverse views.
Gene_expression (joints) of MCP in knee joints associated with arthritis
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.10 Pain Relevance 0.05
We reported that membrane-bound CRegs—MCP, DAF, and CD59—are differentially expressed in normal human and eyes [33].
Gene_expression (expressed) of CRegs MCP in eyes
12) Confidence 0.04 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.06 Pain Relevance 0.03
Patients with atypical HUS should, therefore, undergo complement factor determination (C3, factor H, factor I, factor B, and MCP expression), genotyping (factor H, factor H-linked genes, factor I, MCP, factor B and C3) and determination of anti-factor H antibodies prior to renal Tx so that the risk of graft failure can be evaluated [6].
Spec (determination) Gene_expression (expression) of MCP associated with hemolytic uremic syndrome
13) Confidence 0.03 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 1.87 Pain Relevance 0
In MCP mutation, HUS usually presents in children older than 1 year of age as a recurrent disease of native kidneys.
Gene_expression (mutation) of MCP associated with hemolytic uremic syndrome and disease
14) Confidence 0.03 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 1.76 Pain Relevance 0
Figure 5 shows that ARA treatment particularly increased expression of monocyte chemotactic protein (MCP)-1 and angiogenin, while EPA treatment increased IL-10, IL-6, macrophage inflammatory protein (MIP)-1?
Gene_expression (expression) of MCP in macrophage associated with inflammation
15) Confidence 0.02 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.28 Pain Relevance 0.27
Plasma levels of interleukin (IL)-8, macrophage-colony stimulating factor (M-CSF) and monocyte chemoattractant protein-1 (MCP)-1 were measured by enzyme-linked immunosorbent assay.
Gene_expression (levels) of MCP in monocyte
16) Confidence 0.01 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11369010 Disease Relevance 0.52 Pain Relevance 0.63

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