INT95929

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 7.12
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cfp)
Anatomy Link Frequency
amacrine cells 1
face 1
Cfp (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 62 96.44 Very High Very High Very High
depression 96 81.84 Quite High
drug abuse 1 80.60 Quite High
chemokine 13 79.28 Quite High
cannabis 7 77.92 Quite High
Hippocampus 19 77.28 Quite High
Cannabinoid 13 69.80 Quite High
agonist 33 63.84 Quite High
Neurotransmitter 14 61.92 Quite High
GABAergic 5 58.00 Quite High
Disease Link Frequency Relevance Heat
Poisoning 1519 100.00 Very High Very High Very High
Food Poisoning 7 99.90 Very High Very High Very High
Suicidal Behaviour 8 99.44 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 5 97.28 Very High Very High Very High
Schizophrenia 20 96.68 Very High Very High Very High
Ciguatera Poisoning 378 95.80 Very High Very High Very High
Toxicity 224 91.24 High High
Affective Disorder 6 82.24 Quite High
Depression 105 81.84 Quite High
Drug Dependence 2 80.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colocalization experiments with the general amacrine cell marker HPC-1 [47-49] confirmed the presence of CFP in amacrine and displaced amacrine cells in the INL and GCL, respectively.
CFP Binding (presence) of in amacrine cells
1) Confidence 0.27 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.06 Pain Relevance 0.06
Interestingly, and contrary to other microalgal toxins implicated in food poisoning, no recognized official method for the determination of CFP toxins exists.

3.2.

CFP Neg (no) Spec (determination) Binding (recognized) of associated with food poisoning and poisoning
2) Confidence 0.11 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.26 Pain Relevance 0
Their involvement in CFP is debatable; these species do not produce CTXs, but do produce other toxins.
CFP Binding (involvement) of associated with poisoning
3) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.61 Pain Relevance 0
CFP risk management
CFP Binding (management) of associated with poisoning
4) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.82 Pain Relevance 0
The risk analysis approach is highly advisable to face CFP and establish recommendations when dealing with CFP and public safety.
CFP Binding (advisable) of in face associated with poisoning
5) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.83 Pain Relevance 0
Moreover, misinterpretation of the CFP-induced saupe consumption [279] with Caulerpa poisoning was proposed by Chevaldonn├ę [37].
CFP Binding (misinterpretation) of associated with poisoning
6) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.77 Pain Relevance 0
The cyanobacteria of the genus Hydrocoleum K├╝tzing was recently proposed as a new additional source of CFP based upon the occurrence of unclassical CFP outbreaks after the consumption of giant clams and molluscivorous fish [80].
CFP Binding (source) of associated with poisoning
7) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.63 Pain Relevance 0
In a context where the importance of CFP may be recognized world-wide, and considering the possible increase of CFP cases in traditionally non-endemic areas in Europe and elsewhere, it becomes clear that CFP risk analysis has to be improved to reduce CFP impact.

2.

CFP Binding (recognized) of associated with poisoning
8) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 1.10 Pain Relevance 0
CPZ-treated mice showed PPI deficits while they had higher levels of DA in their PFC, suggesting an association between these two variables.
PFC Binding (association) of
9) Confidence 0.09 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.44 Pain Relevance 0.07
Accordingly, Vinod et al [97] reported elevated levels of endocannabinois, CB1 receptors and CB1 receptors mediated GTP binding in the PFC of alcoholic suicides, adding further support to an involvement of hyperactivity of the endocannabinoid system in suicides [98].
PFC Binding (binding) of associated with endocannabinoid, suicidal behaviour and attention deficit hyperactivity disorder
10) Confidence 0.07 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 1.54 Pain Relevance 0.47
CONCLUSIONS: (1) Enhanced ACh transmission in the vmPFC induces anxiety in challenging environments and enhances spontaneous working memory performance. (2) Blocking or activating postsynaptic M1 receptors in the vmPFC may truncate or exaggerate, respectively, afferent anxiety-relevant information. (3) IL pirenzepine and McN-A-343 exert long-term opposite effects on aversive learning during trial 1 in the elevated plus-maze.


vmPFC Binding (exaggerate) of
11) Confidence 0.06 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11374337 Disease Relevance 0 Pain Relevance 0
2AAR-YFP/CFP to become internalized following stimulation, whereas upon activation with CCL2 CCR2 was readily detected on endosomal structures (Figure 4B).
CFP Binding (internalized) of
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855346 Disease Relevance 0.05 Pain Relevance 0.14

General Comments

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