INT95930

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 63
Total Number 69
Disease Relevance 18.37
Pain Relevance 17.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
hippocampus 6
neurons 5
spinal cord 2
pyramidal neurons 2
synapses 2
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 166 100.00 Very High Very High Very High
Glutamate 118 100.00 Very High Very High Very High
depression 193 99.92 Very High Very High Very High
IPN 47 99.84 Very High Very High Very High
nMDA receptor antagonist 36 99.84 Very High Very High Very High
tetrodotoxin 15 99.82 Very High Very High Very High
Spinal cord 71 99.78 Very High Very High Very High
Pyramidal cell 346 99.76 Very High Very High Very High
Hippocampus 1359 99.72 Very High Very High Very High
central sensitization 38 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 16 100.00 Very High Very High Very High
Targeted Disruption 365 99.96 Very High Very High Very High
Depression 193 99.92 Very High Very High Very High
Inflammatory Pain 47 99.84 Very High Very High Very High
Thiamine Deficiency 124 99.82 Very High Very High Very High
Anxiety Disorder 789 99.60 Very High Very High Very High
Aids-related Complex 183 99.34 Very High Very High Very High
Epilepsy 22 99.06 Very High Very High Very High
Convulsion 293 98.92 Very High Very High Very High
Opiate Addiction 8 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to quantify the loss of GluR2 mRNA, we analyzed the percentage of neurons that contain GluR2 mRNA at 6 and 8 weeks of age in control and GluR2-cKO mice in these brain regions (Fig. 1H).
Negative_regulation (loss) of GluR2 in neurons
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.28
Mutant mice were engineered with a conditional genetic deletion of GluR2 in the CA1 region of the hippocampus (GluR2-cKO mice).
Negative_regulation (deletion) of GluR2 in hippocampus associated with hippocampus
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.26
Isoflurane and halothane caused minimal inhibition of AMPA receptors at clinically relevant concentrations.
Negative_regulation (inhibition) of AMPA
3) Confidence 0.56 Published 2001 Journal Anesthesiology Section Body Doc Link 11374610 Disease Relevance 0 Pain Relevance 0
Electrophysiologic methods examined the inhibition of AMPA receptors by isoflurane and halothane.
Spec (examined) Negative_regulation (inhibition) of AMPA
4) Confidence 0.56 Published 2001 Journal Anesthesiology Section Body Doc Link 11374610 Disease Relevance 0 Pain Relevance 0
It is interesting to note that Purcell et al. [21] reported that the AMPA receptor density was decreased in the cerebellum of individuals with autism.
Negative_regulation (decreased) of AMPA receptor in cerebellum associated with autism
5) Confidence 0.53 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC411038 Disease Relevance 0.85 Pain Relevance 0.39
In the controls we observed no loss of GluR2 in dorsal hippocampus CA1 at 8 weeks compared to 6 weeks of age (p>.05).
Neg (no) Negative_regulation (loss) of GluR2 in hippocampus CA1 associated with hippocampus
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.22
We also found no statistically significant loss of GluR2 from pyramidal neurons in the CA1 region of the ventral hippocampus of the GluR2-cKO mice at 6 and 8 weeks of age when compared to controls of the same ages (83.9±1.9% vs 80.9±2.2% at 6 weeks and 86.7±4.1% vs 90.5±1.6% at 8 weeks; p values>.05).
Neg (no) Negative_regulation (loss) of GluR2 in pyramidal neurons associated with pyramidal cell and hippocampus
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.16
Loss of GluR2 leads to enhanced LTP at synapses
Negative_regulation (Loss) of GluR2 in synapses associated with long-term potentiation
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.26 Pain Relevance 0.29
To determine if interactions between anesthetics and AMPA receptors account for the increased sensitivity of (-/-) mice, the effects of volatile anesthetics that do not directly inhibit AMPA receptors were examined.
Negative_regulation (inhibit) of AMPA
9) Confidence 0.48 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11374610 Disease Relevance 0 Pain Relevance 0.15
In order to identify the loss of GluR2 mRNA we performed in situ hybridization on brain slices obtained from floxed mice (controls), GluR2-cKO mice and global GluR2-KO mice.
Negative_regulation (loss) of GluR2 in brain
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.08 Pain Relevance 0.30
In addition, cells lacking GluR2 showed c-fos reactivity after fear conditioning, demonstrating that synaptic transmission is intact during learning.
Negative_regulation (lacking) of GluR2 associated with anxiety disorder
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.28 Pain Relevance 0.26
Tissue selective deletion of GluR2 in c-KO mice
Negative_regulation (deletion) of GluR2
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.09 Pain Relevance 0.29
We next confirmed that loss of hippocampal GluR2 mRNA results in loss of GluR2 protein in GluR2-cKO mice.
Negative_regulation (loss) of GluR2
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.26
Similarly, GluR2-cKO mice that received saline were once again impaired in context A, but not context B, relative to control mice that received saline (significant context x genotype interaction, F (1, 21) ?
Negative_regulation (impaired) of GluR2-cKO
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.04
We found that deletion of GluR2 was more effective at blocking initial learning in context A than subsequent learning in context B (significant context x genotype interaction (F (1, 47) ?
Negative_regulation (deletion) of GluR2
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.10 Pain Relevance 0.07
Furthermore, presence of AMPA receptors lacking GluR2 did not lead to increased seizure vulnerability, confirming previous observations [55].
Negative_regulation (lacking) of GluR2 associated with convulsion
16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.28 Pain Relevance 0.22
When compared to control mice, the largest loss of GluR2 from the dorsal hippocampus of GluR2-cKO mice was seen in the CA1 region while minor loss of GluR2 was observed in CA3.
Negative_regulation (loss) of GluR2 in hippocampus associated with hippocampus
17) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.07 Pain Relevance 0.31
Behavioral analyses found that GluR2-cKO mice were impaired on multiple hippocampus-dependent learning tasks that required NMDAR activation.
Negative_regulation (impaired) of GluR2-cKO in hippocampus associated with hippocampus
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947514 Disease Relevance 0.08 Pain Relevance 0.28
In contrast to this conditional deletion, we observed a total loss of GluR2 mRNA from GluR2-KO mice, as expected (Fig. 1G).
Negative_regulation (loss) of GluR2
19) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.31
In contrast, the induction of HFS-LTD is reduced in the SDH of GluR2 mutants.
Negative_regulation (reduced) of GluR2 associated with depression
20) Confidence 0.41 Published 2008 Journal Pain Section Abstract Doc Link 17826911 Disease Relevance 0.32 Pain Relevance 0.66

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