INT95932

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 1 96.52 Very High Very High Very High
Glutamate receptor 2 91.12 High High
Central nervous system 2 88.36 High High
tetrodotoxin 1 76.96 Quite High
Somatostatin 2 75.00 Quite High
Hippocampus 2 75.00 Quite High
Glutamate 1 74.24 Quite High
mu opioid receptor 80 57.80 Quite High
Neuronal excitability 1 53.12 Quite High
gABA 1 50.92 Quite High
Disease Link Frequency Relevance Heat
Repression 14 100.00 Very High Very High Very High
Targeted Disruption 6 93.44 High High
Disease 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration.
Negative_regulation (reduced) of Negative_regulation (Blockade) of AMPA associated with antinociception
1) Confidence 0.35 Published 2001 Journal Anesthesiology Section Title Doc Link 11374610 Disease Relevance 0 Pain Relevance 0.19
Functional interaction between sst(1) and sst(4) is suggested by the finding that their combined activation prevented the CH-275-induced inhibition of AMPA transmission.
Negative_regulation (prevented) of Negative_regulation (inhibition) of AMPA
2) Confidence 0.03 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19811607 Disease Relevance 0.30 Pain Relevance 0.27
This has been postulated because HDAC inhibitors fail to derepress the CTRD repression of some NRSF target genes, such as GluR2 receptor and SCG10 (17,18).
Neg (fail) Negative_regulation (derepress) of Negative_regulation (repression) of GluR2 receptor associated with repression
3) Confidence 0.03 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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