INT95939

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 10.00
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
GSK (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 56 100.00 Very High Very High Very High
Morphine 7 100.00 Very High Very High Very High
Eae 31 99.00 Very High Very High Very High
diabetic neuropathy 53 87.84 High High
Pyramidal cell 9 87.52 High High
unmyelinated 2 84.72 Quite High
Central nervous system 51 77.92 Quite High
Inflammation 141 77.08 Quite High
cytokine 74 59.52 Quite High
ischemia 4 58.16 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 607 100.00 Very High Very High Very High
Stress 194 100.00 Very High Very High Very High
Diabetes Mellitus 183 99.60 Very High Very High Very High
Toxicity 73 99.56 Very High Very High Very High
Disease 872 98.44 Very High Very High Very High
Thyroid Neoplasm 322 98.16 Very High Very High Very High
Hyperinsulinism 10 97.74 Very High Very High Very High
Aging 75 96.80 Very High Very High Very High
Carcinoma 52 95.28 Very High Very High Very High
Urological Neuroanatomy 3 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is conceivable that a decline in metabolic and hormonal function in aging, together with accumulation of oxidative stress, can influence neuronal vulnerability to other concomitant insults and result in neuronal degeneration through activation of apoptotic cascades.

5.5 IGF-1, Wnt signaling and GSK-3?

Positive_regulation (activation) of GSK in neuronal associated with stress, aging and apoptosis
1) Confidence 0.67 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.07 Pain Relevance 0
upregulation of phosphorylating stress kinases like SAPK and GSK-3?
Positive_regulation (upregulation) of GSK associated with stress
2) Confidence 0.67 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.70 Pain Relevance 0.20
Thus the activation of GSK3?
Positive_regulation (activation) of GSK
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
We also provided evidence of involvement of GSK3?
Positive_regulation (involvement) of GSK
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
In Wnt signaling pathways, Akt phosphorylation/activation stimulates GSK3?
Positive_regulation (stimulates) of GSK
5) Confidence 0.49 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.08 Pain Relevance 0
Moreover, this strategy may also benefit from the cytoprotective effects of GSK-3?
Positive_regulation (effects) of GSK
6) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.17 Pain Relevance 0
These pathways also affect the activities of kinases such as PKC, GSK-3?
Positive_regulation (activities) of GSK associated with kinase c
7) Confidence 0.49 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.52 Pain Relevance 0.08
In addition, the SO group had 63% higher levels of phosphorylated GSK3?
Positive_regulation (levels) of GSK
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.31 Pain Relevance 0.13
Consistent with a role of PS on tau phosphorylation, overexpression of mutant PS1 in mice results in activation of GSK-3?
Positive_regulation (activation) of GSK associated with eae
9) Confidence 0.49 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.21 Pain Relevance 0.18
The phosphorylation based inactivation of GSK3?
Positive_regulation (inactivation) of GSK
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Inactivation of GSK-3?
Positive_regulation (Inactivation) of GSK
11) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.67 Pain Relevance 0
Furthermore, inactivation of GSK-3?
Positive_regulation (inactivation) of GSK
12) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.63 Pain Relevance 0
toxicity [199] by a mechanism involving Akt and GSK-3?
Positive_regulation (involving) of GSK associated with toxicity
13) Confidence 0.49 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.20 Pain Relevance 0
For instance, NFT formation is induced through activation (dephosphorylation) of GSK-3?
Positive_regulation (activation) of GSK
14) Confidence 0.49 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.32 Pain Relevance 0
For instance, the inactivation of GSK-3?
Positive_regulation (inactivation) of GSK
15) Confidence 0.49 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.17 Pain Relevance 0.04
Another study showed that inactivation of GSK-3?
Positive_regulation (inactivation) of GSK
16) Confidence 0.49 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.33 Pain Relevance 0.03
H9C2 cells raised in 25 mmol/l compared with 5.56 mmol/l glucose media also demonstrated reduced morphine-induced P-GSK3beta, P-Akt, P-STAT3, and P-ERK1 after 15 min.
Positive_regulation (morphine-induced) of GSK associated with morphine
17) Confidence 0.49 Published 2007 Journal Diabetes Section Abstract Doc Link 17192474 Disease Relevance 0.54 Pain Relevance 0.58
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Positive_regulation (increased) of GSK
18) Confidence 0.45 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.98 Pain Relevance 0.04
We conclude that during euglycemic hyperinsulinemia, a low-dose fructose infusion causes a threefold increase in net hepatic glycogen synthesis exclusively through stimulation of glycogen synthase flux.
Positive_regulation (stimulation) of glycogen synthase associated with hyperinsulinism
19) Confidence 0.37 Published 2001 Journal Diabetes Section Abstract Doc Link 11375325 Disease Relevance 0.10 Pain Relevance 0.06

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