INT95961

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.50
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr1a) plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
neurons 2
Htr1a (Mus musculus)
Pain Link Frequency Relevance Heat
5HT 7 100.00 Very High Very High Very High
Serotonin 9 98.24 Very High Very High Very High
fluoxetine 45 96.56 Very High Very High Very High
antidepressant 8 94.88 High High
medulla 15 92.40 High High
Raphe 6 89.72 High High
sSRI 1 80.32 Quite High
Raphe magnus 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 6 98.00 Very High Very High Very High
Sprains And Strains 3 94.08 High High
Catalepsy 6 88.12 High High
Targeted Disruption 7 82.56 Quite High
Acidosis 57 81.36 Quite High
Depression 3 77.44 Quite High
Sudden Infant Death Syndrome 6 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Rare Diseases 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, they suggest that the absence of release-regulating 5-HT1A autoreceptors in the DRN can not account for the anxiety phenotype of KO mice.
Localization (release) of 5-HT1A in DRN associated with anxiety disorder
1) Confidence 0.78 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376590 Disease Relevance 0.17 Pain Relevance 0.36
Indeed, the 5-HT neurons play a crucial role in respiratory function and dysfunction [14]: they are intrinsically chemosensitive [12], synaptically contact the respiratory neurons [15] and exert a facilitatory modulation on the RRG via a release of endogenous 5HT and activation of 5-HT1A receptors [16], [36].
Localization (release) of 5-HT1A in neurons associated with 5ht
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.34 Pain Relevance 0.38
The present studies used in vivo microdialysis and homologous recombination techniques to examine the contribution of 5-HT1A autoreceptors to these effects.
Spec (examine) Localization (contribution) of 5-HT1A
3) Confidence 0.73 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376590 Disease Relevance 0.26 Pain Relevance 0.38
No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice.
Localization (receptor) of 5-HT1A associated with serotonin
4) Confidence 0.73 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 19445393 Disease Relevance 0.73 Pain Relevance 0.55

General Comments

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