INT95971

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 15
Disease Relevance 5.61
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
brain 2
fibroblast 2
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 18 100.00 Very High Very High Very High
antagonist 2 99.96 Very High Very High Very High
opioid receptor 1 99.74 Very High Very High Very High
tolerance 12 99.66 Very High Very High Very High
COX-2 inhibitor 4 98.80 Very High Very High Very High
Pain 3 98.44 Very High Very High Very High
Antinociceptive 4 97.36 Very High Very High Very High
Bile 9 96.48 Very High Very High Very High
nMDA receptor antagonist 2 95.24 Very High Very High Very High
tail-flick 2 92.68 High High
Disease Link Frequency Relevance Heat
Cancer 116 99.76 Very High Very High Very High
Osteogenic Sarcomas 180 99.08 Very High Very High Very High
Tics 9 97.28 Very High Very High Very High
Neurological Disease 1 97.20 Very High Very High Very High
Toxicity 38 97.04 Very High Very High Very High
Metastasis 2 91.60 High High
Breast Cancer 32 90.72 High High
INFLAMMATION 4 86.00 High High
Malignant Neoplastic Disease 18 83.68 Quite High
Pain 1 82.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we have demonstrated that both synthetic-based and plasmid-based siRNA can significantly block MDR1 expression in drug resistant cell lines [15].
Negative_regulation (block) of Gene_expression (expression) of MDR1
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.21 Pain Relevance 0
Our results showed that by treating drug resistant osteosarcoma cell lines with MDR1 siRNA nanoparticles at concentrations of 30 nM or higher, the expression of P-gp was effectively suppressed in both the KHOSR2 and the U-2OSR2 cells.
Negative_regulation (suppressed) of Gene_expression (expression) of P-gp associated with osteogenic sarcomas
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.62 Pain Relevance 0
Moreover, it has been suggested that COX-2 inhibitors may contribute to maintain high levels of chemotherapeutics in tumor tissues by preventing the overexpression of the multidrug resistance protein MDR1/P-gp.
Negative_regulation (preventing) of Gene_expression (overexpression) of P-gp associated with cancer and cox-2 inhibitor
3) Confidence 0.57 Published 2005 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15850674 Disease Relevance 0.88 Pain Relevance 0.59
Oxymatrine inhibits development of morphine-induced tolerance associated with decreased expression of P-glycoprotein in rats.
Negative_regulation (decreased) of Gene_expression (expression) of P-glycoprotein associated with pain, tolerance and morphine
4) Confidence 0.57 Published 2010 Journal Integr Cancer Ther Section Title Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.25
MDR1 siRNA loaded nanoparticle inhibited the expression of P-gp at a concentration of as low as 30 nM (Fig. 3A, B). siRNA transfected with siPORT™ NeoFX™ Transfection Agent was able to suppress P-gp expression for 48 hours (Fig. 4A). siRNA loaded nanoparticles were slower in achieving the suppression of P-gp, but were able to maintain suppression for 96 hours (Fig. 4B).


Negative_regulation (inhibited) of Gene_expression (expression) of P-gp
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
MDR1 siRNA loaded nanoparticle inhibits P-gp-mediated efflux of calcein AM
Negative_regulation (inhibits) of Gene_expression (nanoparticle) of MDR1 siRNA
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
We observed that MDR1 siRNA loaded dextran nanoparticles efficiently suppresses P-gp expression in the drug resistant osteosarcoma cell lines.
Negative_regulation (suppresses) of Gene_expression (expression) of P-gp associated with osteogenic sarcomas
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2875382 Disease Relevance 0.29 Pain Relevance 0
MDR1 siRNA loaded nanoparticle inhibits P-gp-mediated efflux of calcein AM
Negative_regulation (loaded) of Gene_expression (nanoparticle) of MDR1 siRNA
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
In addition, MDR1 siRNA loaded nanoparticles were able to suppress the expression of P-gp for a longer period of time compared to MDR1 siRNA transfected with commercially available agents (96 hr compared to 48 hr).
Negative_regulation (suppress) of Gene_expression (expression) of P-gp
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.59 Pain Relevance 0.03
Duration of MDR1 reversal
Negative_regulation (Duration) of Gene_expression (reversal) of MDR1
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
Although P-gp expression in these tissues is relatively low, it may play an important role in protecting rapidly dividing cells from toxicity after exposure to anticancer drugs [42].
Negative_regulation (low) of Gene_expression (expression) of P-gp associated with toxicity
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.43 Pain Relevance 0.05
A high dose of oxymatrine (30 mg/kg) also significantly inhibited the dramatic increase in expression of morphine-induced P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier, by Western blot analysis.
Negative_regulation (inhibited) of Gene_expression (expression) of P-glycoprotein in brain associated with morphine
12) Confidence 0.42 Published 2010 Journal Integr Cancer Ther Section Abstract Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.21
Herein we review general mechanisms of drug resistance, including multidrug resistance by P-glycoprotein and the multidrug resistance protein family in association with specific agents and their metabolism, emergence of refractory tumors associated with multiple resistance mechanisms, and resistance factors unique to host-tumor-drug interactions.
Negative_regulation (metabolism) of Gene_expression (resistance) of P-glycoprotein associated with cancer
13) Confidence 0.41 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17993229 Disease Relevance 1.77 Pain Relevance 0
The observed effect is due to quenching of MDR-1 and MRP-1 genes expression, which results in blocking of efflux of DOX outside the cells, which in turn correlates with enhanced apoptotic effects.
Negative_regulation (quenching) of Gene_expression (expression) of MDR-1
14) Confidence 0.28 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20037485 Disease Relevance 0.06 Pain Relevance 0
Analogues Dmt-Tic (2',6'-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) pharmacophore, a potent delta-opioid receptor antagonist, inhibited hMDR1 P-GP expressed in a G-185 fibroblast cell line in a manner similar to verapamil.
Negative_regulation (inhibited) of Gene_expression (expressed) of hMDR1 in fibroblast associated with tics, antagonist and opioid receptor
15) Confidence 0.02 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376603 Disease Relevance 0.75 Pain Relevance 0.21

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