INT95976

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.86
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
neurons 1
nervous system 1
Accn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 2 97.00 Very High Very High Very High
ASIC 18 91.40 High High
Neuropeptide 2 91.16 High High
Action potential 1 88.96 High High
Sciatic nerve 2 84.76 Quite High
dorsal root ganglion 6 83.44 Quite High
aspirin 1 78.32 Quite High
Neuropathic pain 2 75.00 Quite High
Pain 3 73.28 Quite High
Peripheral nervous system 1 53.96 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 98.64 Very High Very High Very High
Neuropathic Pain 2 75.00 Quite High
Pain 3 73.28 Quite High
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the expression of ASIC4 showed a small difference in expression at 7 days post ligation.
Gene_expression (expression) of ASIC4
1) Confidence 0.76 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11376855 Disease Relevance 0.24 Pain Relevance 0.33
ASIC2b, ASIC3, and ASIC4 were expressed to a lesser degree in vestibular ganglion neurons.
Gene_expression (expressed) of ASIC4 in neurons associated with ganglion cysts
2) Confidence 0.67 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16790596 Disease Relevance 0.25 Pain Relevance 0.35
By applying a statistical method for analysis of multiple variables, partial least squares, we show that the expression change of ASIC4 was significantly altered on the ligated side even though the change was small.
Gene_expression (expression) of ASIC4
3) Confidence 0.51 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11376855 Disease Relevance 0.23 Pain Relevance 0.32
ASIC4 is a member of the acid-sensing ion channel family that is broadly expressed in the mammalian nervous system, but has no known function.
Gene_expression (expressed) of ASIC4 in nervous system
4) Confidence 0.37 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18662336 Disease Relevance 0.07 Pain Relevance 0.20
We demonstrate here that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells, where it associates with ASIC1a and downregulates exogenous ASIC1a expression.
Gene_expression (transfected) of ASIC4 in plasma
5) Confidence 0.32 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18662336 Disease Relevance 0.07 Pain Relevance 0.22

General Comments

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