INT95989

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.58
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Kcnq2) transmembrane transport (Kcnq2)
Anatomy Link Frequency
ovary 1
Kcnq2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 125 100.00 Very High Very High Very High
potassium channel 31 100.00 Very High Very High Very High
Nav1.2 176 99.44 Very High Very High Very High
diclofenac 21 99.22 Very High Very High Very High
anticonvulsant 24 96.54 Very High Very High Very High
cINOD 13 93.68 High High
Myofascial pain syndrome 21 86.48 High High
Hyperalgesia 3 82.16 Quite High
Opioid 1 81.20 Quite High
allodynia 12 80.80 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 16 99.92 Very High Very High Very High
Benign Neonatal Epilepsy 4 98.76 Very High Very High Very High
INFLAMMATION 35 93.44 High High
Hypersensitivity 8 88.16 High High
Temporomandibular Joint Disorders 21 86.48 High High
Hyperalgesia 3 82.16 Quite High
Neuropathic Pain 21 80.80 Quite High
Pain 31 72.48 Quite High
Stroke 2 68.00 Quite High
Temporomandibular Joint Syndrome 64 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both openers activated KCNQ2/Q3 channels by causing a hyperpolarizing shift of the voltage activation curve (-23 and -15 mV, respectively) and by markedly slowing the deactivation kinetics.
Positive_regulation (activated) of KCNQ2
1) Confidence 0.68 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15598972 Disease Relevance 0.25 Pain Relevance 0.37
Enhancement of KCNQ2/Q3 potassium currents may provide an important target for antiepileptic drug development.
Positive_regulation (Enhancement) of KCNQ2
2) Confidence 0.49 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15598972 Disease Relevance 0.28 Pain Relevance 0.28
Both openers increased KCNQ2/Q3 current amplitude at physiologically relevant potentials and led to hyperpolarization of the resting membrane potential.
Positive_regulation (increased) of KCNQ2
3) Confidence 0.49 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15598972 Disease Relevance 0.21 Pain Relevance 0.58
Extracellular application of meclofenamate (EC(50) = 25 microM) and diclofenac (EC(50) = 2.6 microM) resulted in the activation of KCNQ2/Q3 K(+) currents, heterologously expressed in Chinese hamster ovary cells.
Positive_regulation (activation) of KCNQ2 in ovary associated with diclofenac
4) Confidence 0.46 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15598972 Disease Relevance 0.26 Pain Relevance 0.33
Retigabine is a promising new anticonvulsant that has been shown to have a broad-spectrum of activity in animal models of epileptic seizures with a recently described novel mechanism of action which involves specific activation of KCNQ2-5 (Kv7.2-7.5) channels [9,41-43].
Positive_regulation (activation) of KCNQ2 associated with epilepsy and anticonvulsant
5) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936374 Disease Relevance 0.94 Pain Relevance 1.32
This strongly suggested that the presence of Kv2.1-Nav1.2 specifically disturbed the accumulation of sodium channels but not KCNQ2/KCNQ3.
Positive_regulation (accumulation) of KCNQ2 associated with sodium channel and nav1.2
6) Confidence 0.24 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.88
We next addressed the question as to whether Kv2.1-Nav1.2 acts as a dominant negative of sodium channel and KCNQ2/KCNQ3 potassium channel accumulation at the AIS.
Positive_regulation (accumulation) of KCNQ2 associated with sodium channel, nav1.2 and potassium channel
7) Confidence 0.16 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.68
KCNQ2, KCNQ2/Q3, and KCNQ3/Q4 channels were activated to a similar degree as KCNQ4 channels by 10 microM of BMS-204352 and retigabine, respectively.
Positive_regulation (activated) of KCNQ2
8) Confidence 0.15 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11378159 Disease Relevance 0.32 Pain Relevance 0.16
KCNQ2, KCNQ2/Q3, and KCNQ3/Q4 channels were activated to a similar degree as KCNQ4 channels by 10 microM of BMS-204352 and retigabine, respectively.
Positive_regulation (activated) of KCNQ2
9) Confidence 0.15 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11378159 Disease Relevance 0.32 Pain Relevance 0.16

General Comments

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