INT95995

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ3) transmembrane transport (KCNQ3)
Anatomy Link Frequency
heart 1
KCNQ3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Mexiletine 21 72.32 Quite High
potassium channel 8 71.96 Quite High
Neuropathic pain 1 62.24 Quite High
lidocaine 4 18.96 Low Low
Action potential 14 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
action potential duration 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 13 97.20 Very High Very High Very High
Channelopathies 1 92.28 High High
Epilepsy 2 67.68 Quite High
Stroke 1 67.16 Quite High
Neuropathic Pain 1 62.24 Quite High
Disease 6 59.72 Quite High
Sudden Infant Death Syndrome 6 53.84 Quite High
Heart Rate Under Development 3 24.40 Low Low
Syncope 4 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KCNQ2, KCNQ2/Q3, and KCNQ3/Q4 channels were activated to a similar degree as KCNQ4 channels by 10 microM of BMS-204352 and retigabine, respectively.
Positive_regulation (activated) of KCNQ3
1) Confidence 0.67 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11378159 Disease Relevance 0.32 Pain Relevance 0.15
LQT variant 3 (LQT-3) is caused by mutations in SCN5A, the gene coding for the alpha subunit (NaV1.5) of the primary cardiac voltage-gated Na+ channel in the human heart.
Positive_regulation (caused) of LQT variant 3 in heart
2) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

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