INT96

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 2.80
Pain Relevance 8.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
frontal cortex 3
brain 2
heart 2
dorsal 1
blood 1
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 20 100.00 Very High Very High Very High
anesthesia 10 100.00 Very High Very High Very High
cva 1 100.00 Very High Very High Very High
antagonist 11 99.96 Very High Very High Very High
fluoxetine 7 99.76 Very High Very High Very High
opiate 17 99.24 Very High Very High Very High
antidepressant 6 99.24 Very High Very High Very High
agonist 11 98.44 Very High Very High Very High
5HT 2 98.28 Very High Very High Very High
adenocard 9 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 3 99.40 Very High Very High Very High
Arrhythmia Under Development 2 99.28 Very High Very High Very High
Myocardial Infarction 2 98.12 Very High Very High Very High
Shock 6 97.44 Very High Very High Very High
Opiate Addiction 1 88.24 High High
Arrhythmogenic Right Ventricular Dysplasia 3 86.96 High High
Necrosis 1 84.84 Quite High
Cancer 1 84.48 Quite High
Bordatella Infection 1 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects were compared to those of the standard antidepressants imipramine and fluoxetine. [125I]CYP binding to beta-AR was found to be decreased after short as well as after long-term treatment with imipramine (36%, 40%).
beta-AR Binding (binding) of associated with antidepressant and fluoxetine
1) Confidence 0.48 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.17 Pain Relevance 0.39
We used quantitative radioligand receptor-binding-studies to examine in rats the effects of short-term (2 wks) and long-term (8 wks) administration of different SJW extracts and constituents on beta-AR binding in rat frontal cortex.
beta-AR Binding (binding) of in frontal cortex associated with urological neuroanatomy
2) Confidence 0.36 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.17 Pain Relevance 0.36
Experiments using ICI 118, 551, a beta-2 antagonist and betaxolol, a beta-1 antagonist, indicated that the majority of radioactivity in the cortex in vivo was bound specifically to the beta-1 subtype of the receptor whereas in the cerebellum the majority of specific binding was to the beta-2-subtype.
beta-1 Binding (bound) of in cortex associated with antagonist
3) Confidence 0.34 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2995641 Disease Relevance 0 Pain Relevance 0.48
We investigated whether OPR stimulation influences the effects of beta-adrenergic receptor (beta-AR) stimulation in the isolated, isovolumic rat heart and whether the mechanism of such an interaction involves both beta-AR subtypes or an alteration in beta-AR-mediated increase in cAMP.
beta-AR Binding (interaction) of in heart
4) Confidence 0.34 Published 1997 Journal Circulation Section Abstract Doc Link 9133523 Disease Relevance 0 Pain Relevance 0.34
Interaction of anesthesia, beta-receptor blockade, and blood loss in dogs with induced myocardial infarction.
beta-receptor Binding (Interaction) of in blood associated with anesthesia, pressure volume 2 under development, cva and myocardial infarction
5) Confidence 0.31 Published 1976 Journal Anesthesiology Section Title Doc Link 9020 Disease Relevance 0.37 Pain Relevance 0.49
These results indicate that an interaction of the OPR and beta-AR systems occurs proximal to activation of the adenosine 3',5'-cyclic monophosphate-dependent protein kinase of the beta-AR intracellular signaling pathway.
beta-AR Binding (interaction) of in proximal associated with adenocard
6) Confidence 0.29 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124441 Disease Relevance 0.08 Pain Relevance 0.83
Reserpine pretreatment does not alter the affinities of either alpha- or beta-receptor 3H-ligands.
beta-receptor Binding (3H-ligands) of
7) Confidence 0.28 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 212279 Disease Relevance 0 Pain Relevance 0.24
Binding of the beta-receptor ligand dihydroalprenolol (3H-DHA) was significantly reduced in ECS-treated rat brain membranes.
beta-receptor Binding (Binding) of in brain associated with shock
8) Confidence 0.27 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6265964 Disease Relevance 0.62 Pain Relevance 0.57
The effect of dopamine in kainic acid-treated striatal slices was no longer blocked by fluphenazine, but was blocked by propranolol, suggesting an interaction of dopamine with a beta-adrenoceptor in kainic acid-treated slices.
beta-adrenoceptor Binding (interaction) of associated with dopamine
9) Confidence 0.27 Published 1978 Journal Brain Res. Section Abstract Doc Link 27287 Disease Relevance 0 Pain Relevance 0.41
Binding of [3H]WB-4101 to alpha 1-adrenergic receptors after dorsal bundle lesion was augmented generally to a lesser extent than beta-receptor binding, with significantly increased numbers of sites only in the frontal cortex (74%), thalamus (20%) and septum.
beta-receptor Binding (binding) of in frontal cortex associated with urological neuroanatomy and thalamus
10) Confidence 0.25 Published 1980 Journal Brain Res. Section Abstract Doc Link 6244065 Disease Relevance 0.10 Pain Relevance 0.23
Both alpha 1- and beta-receptor binding sites were reduced in number by 25-28% in the cerebellum of dorsal bundle-lesioned rats, whereas intraventricular administration of 6-hydroxydopamine to adult rats, which depletes norepinephrine in the cerebellum by 96%, increased cerebellar alpha 1- and beta-receptor binding by 33-40%.
beta-receptor Binding (binding) of in dorsal
11) Confidence 0.22 Published 1980 Journal Brain Res. Section Abstract Doc Link 6244065 Disease Relevance 0.09 Pain Relevance 0.26
This brief review will focus on the interaction between beta-AR and OPR and its potential physiological and pathophysiological relevance in the heart.
beta-AR Binding (interaction) of in heart
12) Confidence 0.19 Published 2004 Journal Cardiovasc. Res. Section Abstract Doc Link 15276466 Disease Relevance 0.21 Pain Relevance 0.30
Here we show that microinjection of beta-noradrenergic-receptor antagonists, or of an alpha2-receptor agonist, into the bed nucleus of the stria terminalis (BNST) in rats markedly attenuates opiate-withdrawal-induced conditioned place aversion.
beta-noradrenergic-receptor Binding (microinjection) of in nucleus associated with antagonist, agonist, opiate and withdrawal
13) Confidence 0.17 Published 2000 Journal Nature Section Abstract Doc Link 10667795 Disease Relevance 0.09 Pain Relevance 1.14
B1AR number was assessed through the specific binding of 3H-DHA in the presence of ICI 118, 551 (5 x 10(-8) M), a highly selective beta 2-adrenergic receptor antagonist.
B1AR Binding (binding) of associated with antagonist
14) Confidence 0.09 Published 1991 Journal Kokyu To Junkan Section Abstract Doc Link 1664539 Disease Relevance 0.32 Pain Relevance 0.24
Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.
beta-receptor Binding (interactions) of in brain
15) Confidence 0.03 Published 1992 Journal Neurochem. Res. Section Title Doc Link 1318509 Disease Relevance 0 Pain Relevance 1.03
Recent evidence has linked alpha-receptor and beta-receptor activations with ventricular arrhythmia genesis.
beta-receptor Binding (linked) of associated with arrhythmia under development
16) Confidence 0.00 Published 1986 Journal Am. J. Vet. Res. Section Abstract Doc Link 3946887 Disease Relevance 0.34 Pain Relevance 0.26
Myristic acid, did not inhibit ouabain binding, binding to beta-receptor, nor adenylate cyclase activity.
beta-receptor Binding (binding) of
17) Confidence 0.00 Published 1988 Journal J. Recept. Res. Section Abstract Doc Link 2838616 Disease Relevance 0 Pain Relevance 0.29
On the basis of these results, at least two distinct receptors appear to be associated with AC of monkey frontal cortex: (1) a beta-receptor stimulated by isoproterenol and (2) a new type of dopamine or dopamine-norepinephrine receptor, stimulated by either dopamine or norepinephrine.
beta-receptor Binding (associated) of in frontal cortex associated with dopamine and urological neuroanatomy
18) Confidence 0.00 Published 1976 Journal Brain Res. Section Abstract Doc Link 824023 Disease Relevance 0.24 Pain Relevance 0.66

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