INT96034

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 10.21
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc)
Anatomy Link Frequency
Sensory neurons 1
muscle 1
neurons 1
Epibranchial placodes 1
Proc (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 151 99.80 Very High Very High Very High
Inflammation 12 94.64 High High
imagery 51 94.60 High High
chemokine 1 93.52 High High
Central nervous system 12 91.56 High High
cytokine 11 89.60 High High
Neurotransmitter 3 85.68 High High
nociceptor 66 81.80 Quite High
Inflammatory response 2 80.60 Quite High
Pain 9 75.72 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 214 99.80 Very High Very High Very High
Targeted Disruption 110 99.74 Very High Very High Very High
Osteoporosis 46 99.60 Very High Very High Very High
Cancer 222 99.40 Very High Very High Very High
Hypercalcemia 36 99.08 Very High Very High Very High
Malignant Neoplastic Disease 7 98.12 Very High Very High Very High
Death 36 98.00 Very High Very High Very High
Adenocarcinoma 6 96.60 Very High Very High Very High
Coagulation Disorder 10 96.52 Very High Very High Very High
Carcinoma 8 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with inhibitors to factors VIII or IX pose special challenges, but these complications do not obviate participation in home care programmes.
Negative_regulation (inhibitors) of factors VIII
1) Confidence 0.33 Published 2004 Journal Haemophilia Section Abstract Doc Link 14962201 Disease Relevance 0.48 Pain Relevance 0.07
Furthermore, antiangiogenic effects could be observed in both studies with a reduced microvessel density and altered expression levels of angiogenesis-related factors like FLT-1, Neuropillin-2 and VEGF-C, respectively [97, 98].
Negative_regulation (reduced) of factors
2) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.34 Pain Relevance 0
In Brn3a knockout TG the Runx factors are markedly downregulated, leading to a failure to repress TrkB expression in TrkA- and TrkC-expressing neurons.
Negative_regulation (downregulated) of factors in neurons associated with targeted disruption and trigeminal ganglion
3) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.21
Sensory neurons lacking these factors exhibit multiple defects in sensory axon growth, and die in the perinatal period [10-12].
Negative_regulation (lacking) of factors in Sensory neurons
4) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.42 Pain Relevance 0.29
This has indeed been shown for a number of neurotrophic factors that protect in the axotomy paradigm [27].
Negative_regulation (number) of factors
5) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 1.22 Pain Relevance 0.04
Epibranchial placodes appear to arise from a pan-placodal region and a number of regulatory factors control the differentiation of individual placodes.
Negative_regulation (number) of factors in Epibranchial placodes
6) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1995452 Disease Relevance 0.07 Pain Relevance 0.05
It is conceivable that a number of factors could result in time-dependent expansion of ischemic territories including additional clotting caused by vessel damage as well as ischemic depolarization, which have been suggested to propagate damage in other models [50–52].
Negative_regulation (number) of factors associated with coagulation disorder
7) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.45 Pain Relevance 0.16
However, the reduced muscle repair that we observed was not caused by a decrease in growth factors that are key players of muscle regeneration (IGF-1, IGF-2, FGF-2,…), at least at day 7.
Negative_regulation (decrease) of factors in muscle
8) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2866363 Disease Relevance 1.34 Pain Relevance 0.28
We determined the clinical response, effect on quality of life and the cost-effectiveness of treatment with rFVIIa in six boys with long-standing inhibitors to factors VIII or IX, compared with other treatment regimes previously used in these patients.
Negative_regulation (inhibitors) of factors VIII
9) Confidence 0.01 Published 2001 Journal Haemophilia Section Abstract Doc Link 11380632 Disease Relevance 0.06 Pain Relevance 0
This seed and soil hypothesis is supported by the fact that bone is a repository for a number of growth factors and that osteoclastic bone resorption releases these growth factors.
Negative_regulation (number) of factors associated with hypercalcemia and osteoporosis
10) Confidence 0.00 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 2.02 Pain Relevance 0.08
More work is needed to determine whether bisphosphonates truly have antitumor activity in humans, or whether the reduction in tumor burden in bone is due to the reduction of bone-derived growth factors released into the local microenvironment as a consequence of inhibiting osteoclastic bone resorption.
Spec (whether) Negative_regulation (reduction) of factors associated with cancer, hypercalcemia and osteoporosis
11) Confidence 0.00 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 1.51 Pain Relevance 0
In agreement with this, preliminary findings indicate a progressive increase in the expression of pro-angiogenic factors (such as VEGF and FGF2) and a concomitant decrease of angiogenesis-inhibitory factors (particularly TSP-1 and TSP-2) during cen3tel malignant progression, pointing to angiogenesis as a candidate pro-metastatic feature acquired by late-phase metastatic cen3tel cells.
Negative_regulation (decrease) of factors associated with malignant neoplastic disease
12) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.82 Pain Relevance 0

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