INT96039

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.44
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rasgrp1) cytosol (Rasgrp1) Golgi apparatus (Rasgrp1)
endoplasmic reticulum (Rasgrp1) plasma membrane (Rasgrp1) intracellular (Rasgrp1)
Anatomy Link Frequency
striatum 1
Rasgrp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid receptor 1 14 100.00 Very High Very High Very High
Dopamine 94 99.60 Very High Very High Very High
ischemia 2 96.64 Very High Very High Very High
Substantia nigra 18 93.44 High High
COX2 1 25.00 Low Low
anesthesia 1 25.00 Low Low
dopamine receptor 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2 99.08 Very High Very High Very High
Cv Unclassified Under Development 2 96.64 Very High Very High Very High
Reperfusion Injury 1 75.00 Quite High
Dyskinesias 68 50.00 Quite Low
Parkinson's Disease 12 50.00 Quite Low
Disease 42 5.00 Very Low Very Low Very Low
Hyperkinesis 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Tremor 4 5.00 Very Low Very Low Very Low
Thyroid Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CalDAG-GEFII and MOR1 immunostains also were dysregulated across the full extent of the striatum on the side of the lesion in the L-DOPA-treated animals: CalDAG-GEFII was strongly up-regulated, and MOR1 immunostaining was strongly down-regulated (Figure 3A).
Regulation (dysregulated) of CalDAG-GEFII in striatum associated with opioid receptor 1
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0 Pain Relevance 0.62
TH was chosen as a marker of the extent of the dopamine depletion, whereas CalDAG-GEFII and MOR1 are two immunomarkers that have been previously shown to be dysregulated by combined 6-OHDA lesion and L-DOPA therapy [9], [41].
Regulation (dysregulated) of CalDAG-GEFII associated with dopamine and opioid receptor 1
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0 Pain Relevance 0.65
The aim of this study was to investigate the effects of calpain inhibitor-1 (Cal I-1) in an in vivo model of renal I/R injury.
Spec (investigate) Regulation (effects) of Cal I-1 associated with injury
3) Confidence 0.16 Published 2001 Journal Kidney Int. Section Abstract Doc Link 11380809 Disease Relevance 0.44 Pain Relevance 0.09

General Comments

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