INT96047

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.24
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
nerve 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 60 100.00 Very High Very High Very High
gABA 56 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Glutamate 78 99.56 Very High Very High Very High
5HT 26 97.52 Very High Very High Very High
spinal inflammation 4 97.24 Very High Very High Very High
Inflammation 6 94.44 High High
Enkephalin 2 87.76 High High
behavioral therapy 58 83.60 Quite High
Hippocampus 54 67.92 Quite High
Disease Link Frequency Relevance Heat
Appetite Loss 90 100.00 Very High Very High Very High
Eating Disorder 80 99.32 Very High Very High Very High
Low Back Pain 4 97.24 Very High Very High Very High
Stress 164 97.08 Very High Very High Very High
INFLAMMATION 6 94.44 High High
Injury 52 92.12 High High
Cognitive Disorder 39 79.56 Quite High
Post-traumatic Stress Disorder 176 75.52 Quite High
Phobia 1 73.36 Quite High
Weight Gain 2 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NO via nNOS is increased after acute stress (Krukoff and Khalilli 1997; De Oliviera et al 2000) where NO acts predominantly as a neuromodulator by decreasing glutamate release, NO release, NOS activity, and increasing GABA release (see Figure 1 for detailed description) (Harvey 1996; Prast and Philippu 2001).
Positive_regulation (increasing) of Localization (release) of NOS associated with stress, gaba and glutamate
1) Confidence 0.38 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.85 Pain Relevance 0.19
In addition, acute release of NO via nNOS and NMDA receptor activation down-regulates the NMDA receptor, while localized release of 5HT will attenuate the mobilization of Ca2+, NO, and cGMP (Marcoli et al 1997; Maura et al 2000).
Positive_regulation (activation) of Localization (release) of nNOS associated with nmda receptor and 5ht
2) Confidence 0.35 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.82 Pain Relevance 0.50
Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis.
Positive_regulation (inducible) of Localization (infiltration) of nitric oxide synthase associated with spinal inflammation
3) Confidence 0.25 Published 2003 Journal J. Rheumatol. Section Title Doc Link 14677189 Disease Relevance 0.38 Pain Relevance 0.46
The findings indicate the occurrence of vasoactive intestinal peptide (VIP)-immunopositive nerve fibers in fibromuscular septa and the vasculature, nitrergic innervation of the large pulmonary veins showing a plexus of nNOS-immunopositive nerve fibers that also innervate the lung wall and the localization of neuronal nitric oxide synthase (nNOS) in neurons in the lung wall.
Positive_regulation (innervate) of Localization (localization) of nNOS in nerve associated with neuronal nitric oxide synthase
4) Confidence 0.13 Published 2004 Journal Acta Histochem. Section Abstract Doc Link 15186925 Disease Relevance 0.05 Pain Relevance 0.19
The DSM-IV classification scheme for eating disorders recognizes 2 specific diagnoses, anorexia nervosa (AN) and bulimia nervosa (BN), and a residual category termed eating disorder NOS.3
Positive_regulation (eating) of Localization (disorder) of NOS associated with appetite loss and eating disorder
5) Confidence 0.03 Published 2010 Journal The Psychiatric Clinics of North America Section Body Doc Link PMC2928448 Disease Relevance 2.07 Pain Relevance 0.13
Renal sections were used for histologic grading of renal injury and for immunohistochemical localization of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (inducible) of Localization (localization) of nitric oxide synthase
6) Confidence 0.01 Published 2001 Journal Kidney Int. Section Body Doc Link 11380809 Disease Relevance 0.07 Pain Relevance 0

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