INT96068

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 23.94
Pain Relevance 8.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
lungs 4
molar 3
plasma 2
chondrocytes 1
ventricle 1
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 830 100.00 Very High Very High Very High
fibrosis 348 98.82 Very High Very High Very High
cytokine 178 98.38 Very High Very High Very High
rheumatoid arthritis 446 97.68 Very High Very High Very High
antagonist 42 96.16 Very High Very High Very High
Kinase C 2 95.12 Very High Very High Very High
Inflammation 424 93.96 High High
tolerance 5 91.64 High High
Arthritis 116 91.60 High High
nud 4 90.64 High High
Disease Link Frequency Relevance Heat
Injury 87 99.92 Very High Very High Very High
Stomach Cancer 175 99.84 Very High Very High Very High
Pneumonia 161 99.84 Very High Very High Very High
Autoimmune Disease 35 99.82 Very High Very High Very High
Systemic Sclerosis 203 99.76 Very High Very High Very High
Cancer 389 99.56 Very High Very High Very High
Aging 8 99.56 Very High Very High Very High
Adenocarcinoma 51 99.40 Very High Very High Very High
Prostate Cancer 46 99.12 Very High Very High Very High
Hyperoxia 5 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TIMP1 levels were significantly elevated in blood plasma from prostate cancer patients with metastases [52].
Positive_regulation (elevated) of TIMP1 in plasma associated with prostate cancer and metastasis
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 1.26 Pain Relevance 0
In addition to soluble MMPs, ET-1 enhanced the activation of MT1-MMP and the secretion of tissue inibitor of MMP (TIMP-1 and -2) increasing the net MMP/TIMP balance and the gelatinolytic capacity that results in rapid degradation of extracellular matrix (ECM).
Positive_regulation (increasing) of TIMP in extracellular matrix associated with metalloproteinase
2) Confidence 0.45 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.81 Pain Relevance 0.23
Increased TIMP-1 expression has been observed in lung extracts and in BAL fluids after bleomycin administration and after the transfer of the active TGF-beta gene to "fibrosis-prone" C57BL/6 mice [11,14].
Positive_regulation (Increased) of TIMP in lung associated with fibrosis
3) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.64 Pain Relevance 0.31
All patients managed to tolerate a dose providing 18 g EPA per day, with doses between 9 and 27 g daily being taken for at least a month.
Positive_regulation (providing) of EPA
4) Confidence 0.40 Published 2001 Journal Lipids Section Abstract Doc Link 11383684 Disease Relevance 0.76 Pain Relevance 0.22
In humans, increased levels of TIMP protein and RNA are observed in lungs of patients with idiopathic pulmonary fibrosis, and TIMP expression there exceeds that of MMP [12].
Positive_regulation (levels) of TIMP in lungs associated with fibrosis and pulmonary fibrosis
5) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.66 Pain Relevance 0.28
The absence of collagen deposition in KO mice seems to be associated with an elevated MMP-9/TIMP-1 ratio in the lungs.
Positive_regulation (elevated) of TIMP in lungs
6) Confidence 0.38 Published 2005 Journal Respir Res Section Abstract Doc Link PMC548519 Disease Relevance 0.35 Pain Relevance 0.08
In humans, increased levels of TIMP protein and RNA are observed in lungs of patients with idiopathic pulmonary fibrosis, and TIMP expression there exceeds that of MMP [12].
Positive_regulation (increased) of TIMP in lungs associated with fibrosis and pulmonary fibrosis
7) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.66 Pain Relevance 0.28
Ruiz et al. [32] recently observed that MMP-8 and MMP-13 RNA levels decreased and TIMP-1 RNA increased in the paraquat- and hyperoxia-induced pulmonary fibrosis rat model.
Positive_regulation (increased) of TIMP-1 RNA associated with fibrosis, hyperoxia and pulmonary fibrosis
8) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.92 Pain Relevance 0.37
-SMA) and TIMP-1 mRNA were strongly upregulated following repeated CCl4-administration (Figure 3).
Positive_regulation (upregulated) of TIMP-1
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.75 Pain Relevance 0.14
TIMP1 was significantly elevated in PanIN plasma samples as well.


Positive_regulation (elevated) of TIMP1 in plasma
10) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 0.78 Pain Relevance 0
mice and wild-type littermate mice had nearly equivalent increases in collagen and TIMP1 transcripts.
Positive_regulation (increases) of TIMP1
11) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.78 Pain Relevance 0.17
The data indicated that the time point to evaluate EPA-treatment on NF-?
Positive_regulation (evaluate) of EPA
12) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.68 Pain Relevance 0.04
caused significant induction of TIMP-1.
Positive_regulation (induction) of TIMP
13) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.76 Pain Relevance 0.71
The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 (TIMP-1) and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls (n = 32).
Positive_regulation (concentrations) of TIMP associated with metalloproteinase and systemic sclerosis
14) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.92 Pain Relevance 0.18
The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 (TIMP-1) and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls (n = 32).
Positive_regulation (ratio) of TIMP associated with metalloproteinase and systemic sclerosis
15) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.91 Pain Relevance 0.17
, IGFBP3, SPP1/OPN and TIMP1 were increased in PN and tumours relative to AN, with higher levels seen in tumours.
Positive_regulation (increased) of TIMP1 associated with cancer
16) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.06 Pain Relevance 0.14
TIMP1 levels have been found to be elevated in the immediate post-operative period after curative resection for colo-rectal cancers and it took between 28 - 60 days to fall below the pre-operative levels [52].
Positive_regulation (elevated) of TIMP1 associated with rectal cancer
17) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.84 Pain Relevance 0.10
for 72 hours resulted in a time dependent increase in the secreted levels of TIMP-1.
Positive_regulation (increase) of TIMP
18) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.68 Pain Relevance 0.68
As in our study, TIMP1 levels have been found to be elevated in gastric cancer patients compared to healthy controls [50,51].
Positive_regulation (elevated) of TIMP1 associated with stomach cancer
19) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.74 Pain Relevance 0.03
Sagel et al. have shown that cystic fibrosis (CF) patients show significantly elevated MMP levels with increased MMP-9/Timp-1 molar ratios [27].
Positive_regulation (increased) of Timp in molar associated with fibrosis, cystic fibrosis and metalloproteinase
20) Confidence 0.17 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.39 Pain Relevance 0.90

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