INT96073

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.91
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
cleavage 1
brain 1
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 291 96.96 Very High Very High Very High
anakinra 14 93.20 High High
Inflammatory response 40 88.08 High High
Central nervous system 29 80.96 Quite High
cytokine 128 80.84 Quite High
reflex sympathetic dystrophy 3 66.72 Quite High
agonist 11 66.48 Quite High
anesthesia 3 50.00 Quite Low
adenocard 6 39.44 Quite Low
chemokine 15 38.64 Quite Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 218 97.56 Very High Very High Very High
INFLAMMATION 341 96.96 Very High Very High Very High
Infection 52 91.80 High High
Disease 86 90.52 High High
Apoptosis 64 90.16 High High
Nociception 13 87.48 High High
Syndrome 19 85.68 High High
Mitral Valve Prolapse 36 75.28 Quite High
Cryopyrin-associated Periodic Syndromes 14 72.64 Quite High
Cancer 25 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: We show for the first time that caspase-1 and caspase-3 activities localize specifically within neurons after experimental brain trauma.
Localization (localize) of caspase-1 in brain
1) Confidence 0.78 Published 2001 Journal Neurosurgery Section Body Doc Link 11383749 Disease Relevance 0.10 Pain Relevance 0
This fact, together with our present observation that casp1-/- mice present reduced hypernociception induced by TNF-?
Localization (observation) of casp1
2) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.72 Pain Relevance 0.30
and caspase-1 were released into the supernatant, but this effect was completely suppressed in cells obtained from mice that had mutations in the ASC, NALP-3, or caspase-1 genes.
Localization (released) of caspase-1
3) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 1.09 Pain Relevance 0.27
is released extracellularly after enzymatic processing of its precursor molecule pro-IL-1 by caspase-1 (or ICE, interleukin-converting enzyme).
Localization (released) of ICE
4) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 0.80 Pain Relevance 0.13
is released extracellularly after enzymatic processing of its precursor molecule pro-IL-1 by caspase-1 (or ICE, interleukin-converting enzyme).
Localization (released) of caspase-1
5) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 0.80 Pain Relevance 0.13
LL-37 has now been shown to induce caspase-1 activation and secretion of mature IL-1?
Localization (secretion) of caspase-1
6) Confidence 0.15 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.31 Pain Relevance 0.13
secretion [36], was insufficient to induce secretion of IL-33 (data not shown), supporting the lack of a caspase-1 mediated release mechanism for IL-33, while LPS (5–100 ng/ml), shown to promote release of IL-6 and TNF?
Localization (release) of caspase-1
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.03
-actin, cat. no. 241014, caspase 3, cat. no. 241124, no. 241054, caspase 1, cat. no. 241151, TNF, cat. no. 241034, IFN-?
Localization (cat.) of caspase 1
8) Confidence 0.13 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0 Pain Relevance 0
Of these, IL-1F7b (also known as IL-1H, IL-1H4 and IL-1RP1) matured by caspase-1 is capable of binding IL-18R?
Localization (matured) of caspase-1
9) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.14 Pain Relevance 0.03
Pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) activate the inflammasome, resulting in activation of caspase-1 and cleavage of pro-interleukin (IL)-1?
Localization (cleavage) of caspase-1 in cleavage
10) Confidence 0.08 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 0.82 Pain Relevance 0.24
must first be induced by a stimulant, such as LPS, and then cleaved by active caspase-1 produced from activated inflammasomes which causes disappearance of pro IL-1?
Localization (cleaved) of caspase-1
11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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