INT96084

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 8.41
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 3
endothelial cells 2
endothelium 2
plasma 1
leukocytes 1
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 40 98.70 Very High Very High Very High
Restless leg syndrome 2 90.36 High High
Arthritis 12 87.84 High High
Angina 13 86.24 High High
Pain 14 84.40 Quite High
imagery 156 82.24 Quite High
Inflammatory response 8 75.68 Quite High
cytokine 14 57.20 Quite High
chemokine 29 50.00 Quite Low
ischemia 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 62 100.00 Very High Very High Very High
Adhesions 40 100.00 Very High Very High Very High
Atherosclerotic Plaque 2 99.92 Very High Very High Very High
Atherosclerosis 7 99.84 Very High Very High Very High
INFLAMMATION 50 98.70 Very High Very High Very High
Sickle Cell Anemia 8 98.60 Very High Very High Very High
Asthma 6 98.44 Very High Very High Very High
Thrombosis 2 98.40 Very High Very High Very High
Pressure And Volume Under Development 3 96.16 Very High Very High Very High
Syndrome 4 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparing the glucan sulfates, charge density is the most important parameter for P-selectin binding.
P-selectin Binding (binding) of
1) Confidence 0.48 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16780802 Disease Relevance 0.13 Pain Relevance 0.06
The anti-inflammatory activities of heparin have partly been related to inhibition of P-selectin binding.
P-selectin Binding (binding) of associated with inflammation
2) Confidence 0.48 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16780802 Disease Relevance 0.19 Pain Relevance 0.09
Furthermore, we tested the hypothesis that PMP levels are correlated with other markers of platelet activation, such as soluble P-selectin, membrane bound P-selectin (CD62P) and 63.
CD62P Binding (bound) of in platelet
3) Confidence 0.41 Published 2005 Journal Ann. Med. Section Abstract Doc Link 15902848 Disease Relevance 0.84 Pain Relevance 0.09
Furthermore, we tested the hypothesis that PMP levels are correlated with other markers of platelet activation, such as soluble P-selectin, membrane bound P-selectin (CD62P) and 63.
P-selectin Binding (bound) of in platelet
4) Confidence 0.41 Published 2005 Journal Ann. Med. Section Abstract Doc Link 15902848 Disease Relevance 0.84 Pain Relevance 0.09
P-selectin in platelets and endothelial cells mediates adhesive interaction with leucocytes to form thrombi.
P-selectin Binding (interaction) of in platelets
5) Confidence 0.27 Published 2003 Journal Egypt J Immunol Section Abstract Doc Link 15719626 Disease Relevance 0.67 Pain Relevance 0.38
These data suggest that P-selectin, PSGL-1, VLA-4 and VCAM-1 are the most important adhesion molecules involved in monocyte recruitment to atherosclerotic lesions.
P-selectin Binding (recruitment) of in monocyte associated with atherosclerosis and adhesions
6) Confidence 0.26 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 0.97 Pain Relevance 0.08
Microbubbles could also be specifically targeted to inflamed endothelium with antibodies to P-selectin (CD62P).
CD62P Binding (inflamed) of in endothelium
7) Confidence 0.25 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165062 Disease Relevance 0.21 Pain Relevance 0.16
Microbubbles could also be specifically targeted to inflamed endothelium with antibodies to P-selectin (CD62P).
P-selectin Binding (inflamed) of in endothelium
8) Confidence 0.25 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165062 Disease Relevance 0.21 Pain Relevance 0.16
Nevertheless, it should be noted that P-selectin might participate in I/R injury through its role in platelet aggregation and binding to the neutrophils [25].
P-selectin Binding (binding) of in neutrophils associated with injury
9) Confidence 0.23 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.82 Pain Relevance 0
P-selectin in platelets and endothelial cells mediates adhesive interaction with leucocytes to form thrombi.
P-selectin Binding (interaction) of in endothelial cells
10) Confidence 0.09 Published 2003 Journal Egypt J Immunol Section Abstract Doc Link 15719626 Disease Relevance 0.67 Pain Relevance 0.38
The strategy employed was to inhibit P-selectin receptors on activated endothelial cells in circulation, which mitigates interactions between endothelial cells and leukocytes.
P-selectin Binding (receptors) of in endothelial cells
11) Confidence 0.06 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673971 Disease Relevance 1.04 Pain Relevance 0.16
As compared with control subjects, asymptomatic subjects with SCD demonstrated significantly increased platelet activation (P <.01 for P-selectin and annexin V binding), elevated plasma levels of PF4 and betaTG (P <.01 and P <.03, respectively), and increased plasma concentrations of F(1.2), TAT, PAP, and D -dimer (P <.05 in all cases).
P-selectin Binding (binding) of in plasma associated with sickle cell anemia
12) Confidence 0.03 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11385360 Disease Relevance 0.78 Pain Relevance 0.34
The strategy employed was to inhibit P-selectin receptors on activated endothelial cells in circulation, which mitigates interactions between endothelial cells and leukocytes.
P-selectin Binding (receptors) of in leukocytes
13) Confidence 0.02 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673971 Disease Relevance 1.04 Pain Relevance 0.16

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