INT96116

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.57
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
chondrocytes 1
cartilage 1
osteoblasts 1
lung 1
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 7 99.84 Very High Very High Very High
fibrosis 28 99.26 Very High Very High Very High
postherpetic neuralgia 1 98.80 Very High Very High Very High
Neuropathic pain 1 97.28 Very High Very High Very High
cINOD 11 90.84 High High
dexamethasone 4 86.44 High High
reflex sympathetic dystrophy 2 81.00 Quite High
Inflammation 49 80.60 Quite High
Spinal sensitization 1 78.24 Quite High
Kinase C 4 65.44 Quite High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 7 100.00 Very High Very High Very High
Uterine Fibroids 360 99.84 Very High Very High Very High
Pulmonary Fibrosis 6 99.26 Very High Very High Very High
Post Operative Pain 1 98.80 Very High Very High Very High
Neuropathic Pain 1 97.28 Very High Very High Very High
Nociception 1 92.96 High High
Cirrhosis 45 87.80 High High
Fibrosis 40 87.24 High High
Stress 121 86.12 High High
Sprains And Strains 26 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has rarely been described in CRPS I.
Transcription (described) of CRPS I associated with complex regional pain syndromes
1) Confidence 0.44 Published 2001 Journal Arch Phys Med Rehabil Section Abstract Doc Link 11387594 Disease Relevance 1.05 Pain Relevance 0.84
Taken together, ATRA exposure reduced COL1A1 and COL4A1 mRNA expression in leiomyoma cells, approaching expression patterns comparable to myometrial cells.
Transcription (expression) of COL1A1 associated with uterine fibroids
2) Confidence 0.44 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.59 Pain Relevance 0
During the fusion process a metaplastic shift appeared in the arch centra where cells in the intermediate zone between osteoblasts and chondrocytes co-transcribed col1a, col2a, runx2, osteocalcin and osteonectin, as visualized by ISH.
Transcription (transcribed) of col1a in chondrocytes
3) Confidence 0.40 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.22 Pain Relevance 0
To demonstrate that the hypertonicity-induced chondrogenic marker expression was indeed mediated by NFAT5, we used RNAi to confirm that knockdown of NFAT5 significantly inhibited hypertonic induction of its own transcription as discussed before, significantly suppressed the tonicity-mediated induction of known NFAT5 targets, and, most importantly, significantly eliminated the hypertonicity-mediated mRNA expression of chondrogenic marker genes (COL2, AGC1, SOX9 and COL1).


Transcription (expression) of COL1
4) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.06 Pain Relevance 0.03
In cultured stellate cells, it has been demonstrated that ATRA can prevent morphological transition towards a myofibroblast phenotype and decrease collagen 1 synthesis.37 In addition, ATRA can inhibit radiation-induced pulmonary fibrosis.39 The authors report inhibition of COL1A1 mRNA expression by ATRA in irradiated lung tissue.
Transcription (expression) of COL1A1 in lung associated with fibrosis and pulmonary fibrosis
5) Confidence 0.34 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.61 Pain Relevance 0.13
The mRNA expression was increased for collagen genes COL1A1 (2·72 ± 0·55-fold; P < 0·05) and COL4A1 (2·95 ± 0·37-fold; P < 0·05) in leiomyoma cells as compared to myometrial cells prior to treatment (Fig. 3).
Transcription (expression) of COL1A1 associated with uterine fibroids
6) Confidence 0.34 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.80 Pain Relevance 0
The most striking finding was that the mRNA expression of collagen type I, collagen type III, and tenascin-C in mechanically stimulated gels were all significantly upregulated compared to static controls and approached native T/L expression, and that bone and cartilage markers were not upregulated.
Transcription (expression) of collagen type I in cartilage
7) Confidence 0.17 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.43 Pain Relevance 0
During the fusion process a metaplastic shift appeared in the arch centra where cells in the intermediate zone between osteoblasts and chondrocytes co-transcribed col1a, col2a, runx2, osteocalcin and osteonectin, as visualized by ISH.
Transcription (transcribed) of col1a in osteoblasts
8) Confidence 0.13 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.22 Pain Relevance 0
The next step forward was provided by a series of elegant studies by Nieto and coworkers [306,310,311], who adopted the strategy of transfecting rat HSC/MFs to express human CYP2E1: pro-collagen type I transcription and synthesis in transfected cells was proportional to the levels of CYP2E1 and exacerbated by exposure of cells to ethanol or arachidonic acid (that is, conditions leading to CYP2E1-related increased generation of ROS) and prevented by using either antioxidants or specific inhibitors of CYP2E1, such as diallylsulfide.
Transcription (transcription) of pro-collagen type I
9) Confidence 0.09 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.31 Pain Relevance 0.07
The osteogenesis potential of D1-cells were evaluated by testing mRNA expressions of type Ialpha collagen and osteocalcin 2-8 days after treatments, and testing mineralization 1-3 weeks after treatments.
Transcription (expressions) of type Ialpha collagen
10) Confidence 0.06 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17714695 Disease Relevance 0.30 Pain Relevance 0.74

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