INT96129

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 8.79
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) cytoplasm (F3)
Anatomy Link Frequency
monocyte 1
chest 1
F3 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 2 98.96 Very High Very High Very High
palliative 7 75.52 Quite High
Glutamate 4 74.12 Quite High
nud 14 70.16 Quite High
imagery 42 69.52 Quite High
anesthesia 7 61.12 Quite High
isoflurane 7 22.52 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Somatostatin 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 973 100.00 Very High Very High Very High
Pressure And Volume Under Development 28 99.00 Very High Very High Very High
Angina 1 98.96 Very High Very High Very High
Carcinoma 168 98.88 Very High Very High Very High
Reprotox - General 1 14 98.20 Very High Very High Very High
Recurrence 8 97.96 Very High Very High Very High
Thrombosis 2 95.92 Very High Very High Very High
Myocardial Infarction 12 95.88 Very High Very High Very High
Cv General 3 Under Development 1 77.60 Quite High
Severe Combined Immunodeficiency 35 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that 213Bi-DTPA-[F3]2 binds with high affinity to tumor cells, is internalized into the nuclei of tumor cells in vitro and is effective in treatment of peritoneal carcinomatosis.


F3 Binding (binds) of associated with cancer and carcinoma
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 1.57 Pain Relevance 0.07
It has been shown that F3 binds to many tumor entities including breast and prostate cancer suggesting that F3-directed therapy may be widely applicable.
F3 Binding (binds) of associated with cancer and reprotox - general 1
2) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 1.26 Pain Relevance 0.08
A dimer of the vascular tumor homing peptide F3 was chemically coupled to the ?
F3 Binding (coupled) of associated with cancer
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682652 Disease Relevance 1.61 Pain Relevance 0
Blocking of 213Bi-DTPA-[F3]2 binding to tumor cells
F3 Binding (binding) of associated with cancer
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.17 Pain Relevance 0
F3 is a 32 amino acid vascular tumor homing peptide that binds specifically to nucleolin on the surface of tumor cells [14], [15].
F3 Binding (binds) of associated with cancer
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 1.73 Pain Relevance 0
Binding and internalization of 213Bi-DTPA-[F3]2
F3 Binding (Binding) of
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.63 Pain Relevance 0.15
The inset to figure 1 shows that binding of 213Bi-DTPA-[F3]2 to tumor cells can be blocked by an excess of unlabelled peptide consistent with specificity of binding.


F3 Binding (binding) of associated with cancer
7) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.73 Pain Relevance 0
The methionine has been proposed to exist in enzymes with broad specificities and to act as a cushion to accept substrates with different N-terminal sizes [48], LTA4H, which contains the F/YGAMEN motif prefers basic or aromatic residues and AGAMEN is found in F3, which prefers acidic residues.
F3 Binding (found) of
8) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0 Pain Relevance 0
Our structure was modelled based on the most open of these conformations but whether rhiminopeptidase A shares the flexibility of F3 in this region remains to be determined.
F3 Binding (flexibility) of
9) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0 Pain Relevance 0
The model (Fig. 5A) includes residues 95 to 944 of the amino acid sequence and the predicted structure is very similar to that of tricorn interacting factor F3 (r.m.s.d.?
F3 Binding (interacting) of
10) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0 Pain Relevance 0.04
The template selected was the X-ray crystallographic structure of tricorn interacting factor F3 from the archaeon Thermoplasma acidophilum (PDB code 1z5h) [23].
F3 Binding (interacting) of
11) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0 Pain Relevance 0
This study sought to investigate the role tissue factor (TF) and tissue factor pathway inhibitor-1 (TFPI-1) in the regulation of monocyte procoagulant activity in AMI.
tissue factor Binding (investigate) of in monocyte associated with myocardial infarction
12) Confidence 0.02 Published 2001 Journal Blood Section Abstract Doc Link 11389008 Disease Relevance 0.62 Pain Relevance 0.08
We immunohistochemically assessed the localizations and their changes over time of glycoprotein IIb/IIIa, fibrin, von Willebrand factor (vWF), and tissue factor (TF), after the onset of chest pain (<4, 4 to 6, or 6 to 12 hours), in fresh coronary thrombi causing acute myocardial infarction.
tissue factor Binding (time) of in chest associated with angina and myocardial infarction
13) Confidence 0.01 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 16377278 Disease Relevance 0.46 Pain Relevance 0.10

General Comments

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