INT96136

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 19
Disease Relevance 10.21
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
epithelium 1
pineal gland 1
red blood cells 1
T-cell 1
hb (Mus musculus)
Pain Link Frequency Relevance Heat
depression 21 99.60 Very High Very High Very High
fibrosis 485 99.28 Very High Very High Very High
Raphe 6 99.00 Very High Very High Very High
cytokine 21 95.00 High High
agonist 5 93.40 High High
antagonist 17 92.44 High High
Inflammation 62 89.52 High High
Neuropeptide 2 79.64 Quite High
Dopamine 33 68.88 Quite High
Pain 9 67.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 336 100.00 Very High Very High Very High
Disease 149 99.88 Very High Very High Very High
Depression 21 99.60 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 483 99.28 Very High Very High Very High
Mental Disorders 12 98.96 Very High Very High Very High
Manic Depressive Disorder 6 98.96 Very High Very High Very High
Sickle Cell Anemia 8 98.92 Very High Very High Very High
Increased Venous Pressure Under Development 47 98.48 Very High Very High Very High
Schizophrenia 47 98.24 Very High Very High Very High
Pulmonary Disease 448 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In lethally irradiated normal mice that were reconstituted with varying ratios of T-cell-depleted marrow from normal and transgenic "sickle cell" mice, normal myeloid chimerism in excess of 25% was associated with more than 90% normal hemoglobin (Hb).
Hb Binding (associated) of in T-cell associated with sickle cell anemia and targeted disruption
1) Confidence 0.34 Published 2001 Journal Blood Section Abstract Doc Link 11389040 Disease Relevance 1.32 Pain Relevance 0.06
During a 10 min social interaction test in a novel environment, the mean duration per contact was significantly less in HB-EGF KO mice than in control mice, indicating that HB-EGF KO mice spent significantly less time engaging in social contact (P<0.05 vs. control mice) (Fig. 2d).
HB-EGF Binding (engaging) of associated with targeted disruption
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.97 Pain Relevance 0
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family, serves as a neurotrophic molecular and plays a significant role in the brain.
HB-EGF Spec (like) Binding (binding) of in brain
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.54 Pain Relevance 0.17
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family of growth factors that includes EGF, transforming growth factor (TGF)-?
HB-EGF Binding (binding) of
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.10 Pain Relevance 0
Almost 300 patients with lymphproliferative disease were randomized to early (Hb ?
Hb Binding (randomized) of associated with disease
5) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.49 Pain Relevance 0
Recent data suggest an association between high Hb levels and reduced mortality (Rayner et al 2004; Parfrey et al 2005).
Hb Binding (association) of
6) Confidence 0.19 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.93 Pain Relevance 0
could be clearly detected in the alveolar epithelium with some positivity of Hb?
Hb Binding (positivity) of in epithelium
7) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.98 Pain Relevance 0.23
Our studies using Western blot and commercial antibodies indicate that Hb is secreted to these samples and is present mainly as the larger complexes containing both Hb?
Hb Binding (complexes) of
8) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.94 Pain Relevance 0.20
Overall, this suggests that a similar modification not only for Hb?
Hb Binding (only) of
9) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.55 Pain Relevance 0.14
The levels of Hb complexes declined only in IPF for reasons that remain unclear.
Hb Binding (complexes) of associated with fibrosis
10) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.56 Pain Relevance 0.13
A detailed MS-analysis indicated that a disturbance in the complex formation of Hb?
Hb Binding (formation) of
11) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.83 Pain Relevance 0.16
Protein S-nitrosylation of Cys residues also accounts for a large part of the ubiquitous influence of NO on the cellular signal transduction pathway [31,32], and the interactions between NO and the Hb monomers have been shown to regulate physiological responses such as vasodilatation and vasoconstriction [47].
Hb Neg (NO) Binding (interactions) of associated with increased venous pressure under development
12) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.38 Pain Relevance 0.06
The detection of corresponding alterations in Hb?
Hb Binding (alterations) of
13) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.46 Pain Relevance 0.10
Since these oscillators are randomly phased with respect to one another and have different periods, rhythm amplitudes observed in the Hb complex in PMTs, or when the whole area is delineated from images, are naturally reduced as compared to assessment of the individual areas separately (see Fig. 3).
Hb Binding (complex) of
14) Confidence 0.12 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0
The Hb in turn projects to the pineal gland and raphe nuclei (Wang and Aghajanian, 1977; Herkenham and Nauta, 1979; Ronnekleiv and Moller, 1979; Araki et al., 1988), both of which are important for circadian timekeeping (Morin, 1999).
Hb Binding (projects) of in pineal gland associated with raphe
15) Confidence 0.12 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0.34 Pain Relevance 0.29
Nitric oxide binds avidly to haem iron, and haemoglobin (Hb) is released into the circulation when red blood cells (RBC) are disrupted during parasite schizogony.
Hb Binding (binds) of in red blood cells
16) Confidence 0.09 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.70 Pain Relevance 0.05
The phosphorylation of ERK was reduced by tyrphostin AG1478, an inhibitor of phosphorylation of the epidermal growth factor receptor (EGFR), and by heparin, which neutralizes heparin-binding epithelial growth factor (HB-EGF), suggesting the involvement of a transactivation process, in which alpha(2)-adrenergic stimulation leads to proteolytic shedding of HB-EGF (and perhaps other EGFR agonists) from transmembrane-spanning precursors.
HB-EGF Binding (heparin-binding) of associated with agonist
17) Confidence 0.05 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0 Pain Relevance 0.09
protected from reacting with Hb.
Hb Binding (reacting) of
18) Confidence 0.05 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.06 Pain Relevance 0
NO irreversibly by combining with Hb.
Hb Binding (combining) of
19) Confidence 0.04 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.07 Pain Relevance 0

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