INT96137

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 5.27
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LNPEP) peptidase activity (LNPEP) extracellular region (LNPEP)
plasma membrane (LNPEP) intracellular (LNPEP) cell-cell signaling (LNPEP)
Anatomy Link Frequency
blood 1
BeWo 1
JEG-3 1
neuronal 1
uterus 1
LNPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 4 100.00 Very High Very High Very High
Enkephalin 3 99.72 Very High Very High Very High
Pain 3 98.12 Very High Very High Very High
agonist 16 89.92 High High
Dismenorea 12 89.12 High High
opioid receptor 1 81.72 Quite High
antagonist 31 81.24 Quite High
Nerve growth factor 1 75.64 Quite High
nMDA receptor antagonist 1 67.48 Quite High
Dynorphin 2 59.32 Quite High
Disease Link Frequency Relevance Heat
Pre-eclampsia 276 99.44 Very High Very High Very High
Brain Injury 1 98.52 Very High Very High Very High
Pre-term Labor 163 98.48 Very High Very High Very High
Cognitive Disorder 9 98.32 Very High Very High Very High
Pain 3 98.12 Very High Very High Very High
Reprotox - General 1 3 97.68 Very High Very High Very High
Increased Venous Pressure Under Development 18 96.04 Very High Very High Very High
Dysmenorrhea 12 89.12 High High
Heart Rate Under Development 13 83.28 Quite High
Hypoxia 12 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To explore the transcriptional regulation of P-LAP gene expression in placenta, we performed systematic studies using human choriocarcinoma cells, BeWo and JEG-3, as a model of placental trophoblastic cells.
Gene_expression (expression) of P-LAP gene in JEG-3 associated with reprotox - general 1
1) Confidence 0.68 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517297 Disease Relevance 0.20 Pain Relevance 0.10
Our findings suggest that AP-2 may be one of the important factors regulating P-LAP gene expression in human placenta.
Gene_expression (expression) of P-LAP gene in placenta
2) Confidence 0.68 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517297 Disease Relevance 0.12 Pain Relevance 0.06
Of a range of peptides tested, only vasopressin, oxytocin, and met-enkephalin were rapidly cleaved by IRAP.
Gene_expression (cleaved) of IRAP associated with enkephalin
3) Confidence 0.67 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12871575 Disease Relevance 0 Pain Relevance 0.15
Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides.
Gene_expression (Expression) of oxytocinase in neuronal associated with neuropeptide
4) Confidence 0.58 Published 2001 Journal Eur. J. Biochem. Section Title Doc Link 11389728 Disease Relevance 0.07 Pain Relevance 0.26
P-LAP is predominantly synthesized in placental syncytiotrophoblasts and increases in maternal blood with advancing pregnancy [35–39].
Gene_expression (synthesized) of P-LAP in blood
5) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.34 Pain Relevance 0.16
Thus, the trophoblastic degeneration seen during severe preeclampsia may be due to a failure to synthesize APA and P-LAP.
Gene_expression (synthesize) of P-LAP associated with pre-eclampsia
6) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.84 Pain Relevance 0.09
During normal pregnancy, sufficient levels of P-LAP degrade OT and AVP, and APA deactivates AngII, thus protecting the mother.
Gene_expression (levels) of P-LAP
7) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.93 Pain Relevance 0.07
Maternal serum APA and P-LAP activities in early mild preeclampsia patients are higher than those seen in normal pregnancy patients [42, 43].
Gene_expression (activities) of P-LAP associated with pre-eclampsia
8) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.55 Pain Relevance 0.12
At term, increases in fetal OT overwhelm P-LAP, resulting in contractions of the uterus triggering the onset of labor.
Gene_expression (overwhelm) of P-LAP in uterus
9) Confidence 0.25 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.92 Pain Relevance 0.08
pups/litter, and in the P-LAP group 6.0 ± 1.8?
Gene_expression (group) of P-LAP
10) Confidence 0.25 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.18 Pain Relevance 0
To explore the transcriptional regulation of P-LAP gene expression in placenta, we performed systematic studies using human choriocarcinoma cells, BeWo and JEG-3, as a model of placental trophoblastic cells.
Gene_expression (expression) of P-LAP gene in BeWo associated with reprotox - general 1
11) Confidence 0.23 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517297 Disease Relevance 0.20 Pain Relevance 0.10
Rationale for proposing that insulin-regulated aminopeptidase is a novel target for the development of cognitive enhancers
Gene_expression (proposing) of insulin-regulated aminopeptidase associated with cognitive disorder
12) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.85 Pain Relevance 0.07
blocker completely obliterated Angiotensin receptor/Gq coupling and contractility, and treatment of mice with a selective angiotensin receptor blocker attenuated heart rate response to a ?
Gene_expression (coupling) of Angiotensin receptor in heart
13) Confidence 0.03 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.08 Pain Relevance 0.18

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