INT96140

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Context Info
Confidence 0.22
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 32
Disease Relevance 12.87
Pain Relevance 28.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gimap1)
Anatomy Link Frequency
neurons 7
skin 5
IAN 2
upper 2
covering 1
Gimap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
inferior alveolar nerve 4540 100.00 Very High Very High Very High
Neuropeptide 69 99.98 Very High Very High Very High
trigeminal ganglion 1983 99.72 Very High Very High Very High
tetrodotoxin 1740 99.50 Very High Very High Very High
Action potential 660 99.44 Very High Very High Very High
Peripheral nerve injury 120 99.00 Very High Very High Very High
hyperexcitability 240 98.96 Very High Very High Very High
fifth nerve 63 98.80 Very High Very High Very High
Spinal cord 6 98.32 Very High Very High Very High
Neuronal excitability 120 98.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2073 99.72 Very High Very High Very High
Peripheral Arterial Disease 36 99.54 Very High Very High Very High
Hypersensitivity 61 99.44 Very High Very High Very High
Nervous System Injury 511 99.16 Very High Very High Very High
Injury 186 98.44 Very High Very High Very High
Congenital Anomalies 61 96.92 Very High Very High Very High
Nociception 31 91.64 High High
Pain 300 81.44 Quite High
Neuropathic Pain 241 69.00 Quite High
Infection 30 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fos protein-like immunoreactive (LI) cells were observed in the superficial laminae but not dominant in deeper laminae of the trigeminal spinal nucleus caudalis (Vc) and the first segment of the spinal cord (C1) after non-noxious mechanical stimulation of the whisker pad area in the rats with IAN transection.
Gene_expression (transection) of IAN in whisker associated with peripheral arterial disease and spinal cord
1) Confidence 0.22 Published 2002 Journal Pain Section Abstract Doc Link 11839422 Disease Relevance 0.50 Pain Relevance 0.34
Figure 1E (ipsilateral side to IAN transection) and F (contralateral side to IAN transection) illustrate the mechanical threshold intensity for evoking escape behavior by mechanical stimulation of the mental skin region before and 7-14 days after IAN transection.
Gene_expression (transection) of IAN in skin associated with inferior alveolar nerve
2) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.45 Pain Relevance 0.72
We used IAN-transected rats which showed hypersensitivity to mechanical stimulation of the mental skin and IAN-transected rats without behavior changes which did not show any behavioral changes after IAN transection for single fiber recording experiments.
Gene_expression (transection) of IAN in skin associated with inferior alveolar nerve and hypersensitivity
3) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.10 Pain Relevance 0.64
The escape threshold was measured before the IAN was transected and then the IAN of those rats was transected.
Gene_expression (transected) of IAN associated with inferior alveolar nerve
4) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.26 Pain Relevance 0.44
TTX-R INa was much larger than TTX-S INa in both naive and IAN-transected rats (Figure 4Ac, d, e, f).
Gene_expression (rats) of IAN-transected associated with tetrodotoxin and inferior alveolar nerve
5) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.30 Pain Relevance 1.88
Although the number of FG-labeled TG neurons at 7 and 14 days after IAN transection was significantly smaller than that in naive rats, the number of neurons at 14 days was significantly larger compared to that at 7 days (Figure 1D).


Gene_expression (transection) of IAN in neurons associated with inferior alveolar nerve and trigeminal ganglion
6) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.98 Pain Relevance 0.97
The threshold current for spike generation was significantly smaller in IAN-transected rats than that of naive rats and current injection into TG neurons induced high-frequency spike discharges in rats with IAN transection.
Gene_expression (transection) of IAN in spike associated with inferior alveolar nerve and trigeminal ganglion
7) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 1.06 Pain Relevance 1.52
In the case of IAN transection for example, IAN fibers show significant increases in background activity and also trigeminal ganglion (TG) neurons show a change in the expression of several types of Na+ channels [33-37].
Gene_expression (transection) of IAN in IAN associated with ganglion cysts, inferior alveolar nerve and trigeminal ganglion
8) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.55 Pain Relevance 0.72
In this case (upper 4 traces in Figure 5B), the spike amplitude was slightly decreased in naive and IAN-transected rats after administration of 1 ?
Gene_expression (rats) of IAN-transected in upper associated with inferior alveolar nerve
9) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.15 Pain Relevance 1.53
We used IAN-transected rats which showed hypersensitivity to mechanical stimulation of the mental skin and IAN-transected rats without behavior changes which did not show any behavioral changes after IAN transection for single fiber recording experiments.
Gene_expression (rats) of IAN-transected in skin associated with inferior alveolar nerve and hypersensitivity
10) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.10 Pain Relevance 0.55
Only rats with IAN transection which showed a significant decrement in mechanical escape threshold at 14 days after IAN transection were used for single fiber and patch clamp recording experiments (see below).
Gene_expression (transection) of IAN associated with inferior alveolar nerve
11) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.21 Pain Relevance 0.44
Rats were divided into 3 groups: ipsilateral to IAN transection (n = 16), ipsilateral to IAN without behavioral changes after IAN transection (n = 5) and naive groups (n = 22).
Gene_expression (transection) of IAN associated with inferior alveolar nerve
12) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.09 Pain Relevance 0.63
Total INa in TG neurons was larger in IAN-transected rats compared with naive rats, as illustrated in Figure 4Aa (naive rats) and Figure 4Ab (IAN-transected rats).
Gene_expression (rats) of IAN-transected in neurons associated with inferior alveolar nerve and trigeminal ganglion
13) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.58 Pain Relevance 1.07
A small number of FG-labeled neurons were observed in the TG at 7 days after IAN transection and many were evident in the TG at 14 days after IAN transection (Figure 1B and 1C).
Gene_expression (transection) of IAN in neurons associated with inferior alveolar nerve and trigeminal ganglion
14) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 1.10 Pain Relevance 0.98
The total INa (n = 7), TTX-R INa (n = 7) and TTX-S INa (n = 7) were all significantly larger in IAN-transected rats than naive rats (p < 0.05).
Gene_expression (rats) of IAN-transected associated with tetrodotoxin and inferior alveolar nerve
15) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.37 Pain Relevance 1.94
The activity of 76 single fiber activities was recorded from the IAN at 14 days after IAN transection (66 and 10 fibers from IAN-transected rats with and without behavioral changes, respectively) and the activity of 89 IAN fibers was recorded from naive rats.
Gene_expression (transection) of IAN associated with inferior alveolar nerve
16) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.05 Pain Relevance 0.75
Rats were divided into 3 groups: ipsilateral to IAN transection (n = 16), ipsilateral to IAN without behavioral changes after IAN transection (n = 5) and naive groups (n = 22).
Gene_expression (transection) of IAN associated with inferior alveolar nerve
17) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.09 Pain Relevance 0.60
TTX-R INa recorded from TG neurons from IAN-transected rats was significantly larger than these recorded from naive rats (n = 7, p < 0.05) (Figure 4Ad).
Gene_expression (rats) of IAN-transected in neurons associated with tetrodotoxin, inferior alveolar nerve and trigeminal ganglion
18) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.39 Pain Relevance 1.76
Thus, it is very likely that the increase in excitability of TG neurons after IAN transection as documented in the present study makes an important contribution to the increase in the Vc neuronal excitability.
Gene_expression (transection) of IAN in neurons associated with inferior alveolar nerve, neuronal excitability and trigeminal ganglion
19) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.45 Pain Relevance 0.97
In this case (upper 4 traces in Figure 5B), the spike amplitude was slightly decreased in naive and IAN-transected rats after administration of 1 ?
Gene_expression (naive) of IAN-transected in upper associated with inferior alveolar nerve
20) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.15 Pain Relevance 1.53

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