INT96150

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 44
Total Number 48
Disease Relevance 16.23
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (H2-D1)
Anatomy Link Frequency
microglia 3
CD86 3
neurons 3
NK cells 3
T-cells 2
H2-D1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 144 98.72 Very High Very High Very High
cytokine 465 98.32 Very High Very High Very High
Inflammation 576 96.96 Very High Very High Very High
tolerance 90 96.64 Very High Very High Very High
Potency 6 91.32 High High
chemokine 207 90.64 High High
Analgesic 1 90.24 High High
aspirin 11 88.80 High High
Multiple sclerosis 44 87.24 High High
excitatory amino acid 10 86.48 High High
Disease Link Frequency Relevance Heat
Infection 1551 99.88 Very High Very High Very High
Cancer 579 99.84 Very High Very High Very High
Multiple Sclerosis 259 98.96 Very High Very High Very High
Viral Infection 131 97.72 Very High Very High Very High
INFLAMMATION 631 96.96 Very High Very High Very High
Targeted Disruption 358 96.56 Very High Very High Very High
Recurrence 15 95.08 Very High Very High Very High
Disease 101 94.40 High High
Vesicular Stomatitis 12 93.76 High High
Parkinson's Disease 12 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD11c and MHC class I expression were unaffected.
Gene_expression (expression) of MHC class I
1) Confidence 0.27 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.09 Pain Relevance 0.34
Recipient/Donor MHC-I molecules of C57Bl/6 (H-2D[b]) were stable expressed after transplantation (Table 3).
Gene_expression (expressed) of H-2D
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.24 Pain Relevance 0
On day 40 after transplantation of allogeneic NA-BMCs the MHC-I expression of donor Balb/c (H-2K[d]) remained low (3.1±2.6%) while the recipient MHC-I molecules of C57Bl/6(H-2D[b]) were highly expressed (94.3±5.4%) (Figure 4A).
Gene_expression (expressed) of H-2D
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.27 Pain Relevance 0
We only occasionally detected expression of MHC class I or MHC class II on individual perivascular cells suggesting that MHC-positive cells rarely reside within CVOs of healthy mice.
Gene_expression (expression) of MHC class I
4) Confidence 0.15 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.82 Pain Relevance 0.17
Thus, increased expression of MHC class I and II molecules on microglial cells and perivascular macrophages, which are known characteristic immunopathological changes observed in the CNS parenchyma during EAE, are similarly observed in the BBB-deficient areas of the CVOs [22].
Gene_expression (expression) of MHC class I in microglial cells associated with multiple sclerosis and central nervous system
5) Confidence 0.15 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.45 Pain Relevance 0.09
Unlike some cell types such as neurons, which express almost no MHC proteins, murine and human EC express easily detectable levels of MHC class I proteins in vivo [29,30].
Gene_expression (express) of MHC class I in neurons
6) Confidence 0.14 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.10 Pain Relevance 0.16
The low immunogenicity of NSPCs [10] coupled with their low expression of MHC class I and II have popularized their use in transplantation medicine [11], [12].
Gene_expression (expression) of MHC class I and II
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.55 Pain Relevance 0.14
These figures clearly indicate that the surface expression of costimulatory and MHC class I molecules underwent an increase in the Nestin positive cells in the SVZ of JEV infected animals.


Gene_expression (expression) of MHC class I
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.16 Pain Relevance 0
Both T-cells and Natural killer (NK) cells of the host can recognize the foreign progenitors by the surface MHC class I expression and reject the grafted cells.
Gene_expression (expression) of MHC class I in T-cells
9) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.50 Pain Relevance 0.15
Following JEV infection, the expression of CD40, CD80, CD86 as well as MHC class I showed a prominent increase, and was completely colocalised with Nestin + cells in the SVZ (Fig. 1 D, F, H, J).
Gene_expression (expression) of MHC class I in CD86 associated with infection
10) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.17 Pain Relevance 0
In control animals, Nestin + cells in the SVZ show elongated processes and very low expression of all the costimulatory molecules and MHC class I, as detected by dual immunofluorescence using confocal microscopy (Fig. 1 C, E, G, I).
Gene_expression (expression) of MHC class I
11) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.17 Pain Relevance 0
Many researchers have demonstrated absence or negligible expression of MHC class I and II antigen by early and later passaged neurospheres, which protects these cells from immune recognition [9].
Gene_expression (expression) of MHC class I and II
12) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.53 Pain Relevance 0.14
Furthermore, the expression of the costimulatory and MHC class I proteins on Nestin + cells in the JEV infected brain was mainly localised to the surface and partially to the cytoplasm as detected by co-localisation studies with the nuclear stain DAPI (Fig S1).
Gene_expression (expression) of MHC class I in brain
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.20 Pain Relevance 0
Using Flow cytometry and fluorescence microscopy, we observed increased surface expression of co-stimulatory molecule and MHC class I antigen in NSPCs upon progressive JEV infection in vitro.
Gene_expression (expression) of MHC class I associated with infection
14) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2780913 Disease Relevance 0.73 Pain Relevance 0.17
Moreover, enhanced expression of CD80 and CD86, as well as MHC class I (but not MHC class II), is observed in vitro upon exposure of NSPCs to pro-inflammatory cytokines like IFN-?
Gene_expression (expression) of MHC class I in CD86 associated with inflammation and cytokine
15) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.41 Pain Relevance 0.25
-gal peptides are presented by both MHC class I and class II molecules (data not shown).
Gene_expression (presented) of MHC class I
16) Confidence 0.12 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.43 Pain Relevance 0.08
Expression of Costimulatory Molecules and MHC Class I in SVZ during JE Progression
Gene_expression (Expression) of MHC Class I
17) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.09 Pain Relevance 0
Using flow cytometry, we determined the expression of both costimulatory and MHC class I molecules on both control (uninfected) and JEV infected NSPCs at different dpi.
Spec (determined) Gene_expression (expression) of MHC class I
18) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.26 Pain Relevance 0
For example, although human EC strongly express MHC class I and class II molecules in vivo, MHC class I expression is reduced and class II expression is lost in vitro [28,29].
Gene_expression (express) of MHC class I
19) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.05 Pain Relevance 0.04
For example, although human EC strongly express MHC class I and class II molecules in vivo, MHC class I expression is reduced and class II expression is lost in vitro [28,29].
Gene_expression (expression) of MHC class I
20) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.06 Pain Relevance 0.04

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