INT96154

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.76
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd86)
Anatomy Link Frequency
CD86 16
retinas 2
myeloid dendritic cells 2
B cells 2
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 41 100.00 Very High Very High Very High
spastic colon 14 99.54 Very High Very High Very High
cytokine 49 98.20 Very High Very High Very High
Glutamate 2 96.48 Very High Very High Very High
Analgesic 1 96.36 Very High Very High Very High
aspirin 11 94.92 High High
Neuronal nitric oxide synthase 2 91.96 High High
Adalimumab 8 88.56 High High
rheumatoid arthritis 48 85.24 High High
tolerance 3 80.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 48 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 99.54 Very High Very High Very High
Aging 49 98.68 Very High Very High Very High
Stroke 35 98.00 Very High Very High Very High
Cancer 187 97.86 Very High Very High Very High
Adhesions 5 88.80 High High
Stress 14 85.88 High High
Rheumatoid Arthritis 49 85.24 High High
Necrosis 10 76.08 Quite High
Functional Bowel Disorder 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Normal B16 tumor cells shown no effects on IL-12 p70 production but markedly increased IL-10 production, and significantly decreased the expressions of CD80 and CD86.
Negative_regulation (decreased) of Gene_expression (expressions) of CD86 in CD86 associated with cancer
1) Confidence 0.48 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.58 Pain Relevance 0.05
Reduced expression of ETC genes is evident in profiles of aging rods, reported here, but this pathway was not identified in previous profiling studies of whole retinas [26], [27].
Negative_regulation (Reduced) of Gene_expression (expression) of ETC in retinas associated with aging
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.50 Pain Relevance 0.04
Interestingly, ONO-AE1-259-01 has been suggested to elevate cAMP and inhibit expression of inflammatory molecules such as ICAM-1 and B7.2 (CD86) [28,29], and such inflammatory molecules affect stroke outcomes [30,31].
Negative_regulation (inhibit) of Gene_expression (expression) of B7.2 in CD86 associated with inflammation and stroke
3) Confidence 0.41 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.57 Pain Relevance 0.26
KP at 5% or 10% clearly decreased the PCl-augmented expression of major histocompatibility complex class II and CD86 on LCs.
Negative_regulation (decreased) of Gene_expression (expression) of CD86 in CD86
4) Confidence 0.37 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18565185 Disease Relevance 0 Pain Relevance 0
TLR4 deficient mice have reduced CD86 expression on DCs and a reduced ability to promote Th2 cytokines and allergen-specific IgE levels [58].
Negative_regulation (reduced) of Gene_expression (expression) of CD86 in CD86 associated with cytokine
5) Confidence 0.36 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.09
In this study, at physiological concentrations, it profoundly inhibited CD40, CD80, CD86, and MHC class II expression on murine, GM-CSF + IL-4 stimulated, bone marrow-derived myeloid dendritic cells (DC).
Negative_regulation (inhibited) of Gene_expression (expression) of CD86 in myeloid dendritic cells
6) Confidence 0.33 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.10 Pain Relevance 0.31
However, the anti-TNF therapy caused a decrease in the proportion of memory B cells expressing CD86 after 6 months of therapy (P = 0.032) (Figure 6a).
Negative_regulation (decrease) of Gene_expression (expressing) of CD86 in CD86
7) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.40 Pain Relevance 0.25
Interestingly, ONO-AE1-259-01 has been suggested to elevate cAMP and inhibit expression of inflammatory molecules such as ICAM-1 and B7.2 (CD86) [28,29], and such inflammatory molecules affect stroke outcomes [30,31].
Negative_regulation (inhibit) of Gene_expression (expression) of CD86 in CD86 associated with inflammation and stroke
8) Confidence 0.27 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.57 Pain Relevance 0.26
CD86 RNA expression after 24 hrs of LPS stimulation with 0, 1, 5, or 10 ?
Negative_regulation (hrs) of Gene_expression (expression) of CD86 in CD86
9) Confidence 0.26 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.09
The cells were then stained with the desired antibodies, CD40, CD80, CD86, MHC class I (H-2kd) and rat IgG2a?
Negative_regulation (desired) of Gene_expression (antibodies) of CD86 in CD86
10) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0 Pain Relevance 0
B cells of IBS patients displayed an impaired ability to increase expression of CD80, but not CD86, in response to both LPS as well as probiotic bacteria stimulations.
Negative_regulation (impaired) of Gene_expression (expression) of CD86 in B cells associated with spastic colon
11) Confidence 0.14 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19222763 Disease Relevance 0.20 Pain Relevance 1.01

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