INT96155

Context Info Confidence 0.77 First Reported 2001 Last Reported 2010 Negated 4 Speculated 1 Reported most in Body Documents 134 Total Number 135 Disease Relevance 50.56 Pain Relevance 17.13

plasma membrane (Cd86)

Anatomy Link Frequency CD86 83 T cells 14 B cells 11 salivary gland 4 DCs 3 Cd86 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 1079 100.00 aspirin 93 100.00 rheumatoid arthritis 869 99.50 chemokine 208 99.16 cytokine 1106 99.08 spastic colon 36 98.96 Spinal cord 178 98.06 tolerance 56 96.84 Glutamate 3 96.16 Central nervous system 234 96.04

Disease Link Frequency Relevance Heat INFLAMMATION 1176 100.00 Infection 1112 99.88 Candida Infection 412 99.70 Fever 58 99.70 Rheumatoid Arthritis 874 99.50 Influenza Virus Infection 51 99.36 Cancer 1282 99.24 Sprains And Strains 166 99.24 Autoimmune Disease 226 99.04 Adhesions 66 99.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hyperthermia increases the expression of co-stimulatory molecules such as CD80 and CD86.

Gene_expression (expression) of CD86 in CD86 associated with fever

1) Confidence 0.77 Published 2006 Journal Vaccine Section Abstract Doc Link 16735086 Disease Relevance 1.11 Pain Relevance 0.18

However, there was a significant difference in CD86 (B7.2) expression on B cells.

Gene_expression (expression) of B7.2 in B cells

2) Confidence 0.75 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.19 Pain Relevance 0.05

Previous reports indicate that the isolated NSPCs express costimulatory molecules, like CD80 (B7.1) and CD86 (B7.2), though their exact functions have not been elucidated.

Gene_expression (express) of B7.2 in CD86

3) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.60 Pain Relevance 0.21

Reduced expression of ETC genes is evident in profiles of aging rods, reported here, but this pathway was not identified in previous profiling studies of whole retinas [26], [27].

Gene_expression (expression) of ETC in retinas associated with aging

4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.49 Pain Relevance 0.04

Interestingly, ONO-AE1-259-01 has been suggested to elevate cAMP and inhibit expression of inflammatory molecules such as ICAM-1 and B7.2 (CD86) [28,29], and such inflammatory molecules affect stroke outcomes [30,31].

Gene_expression (expression) of B7.2 in CD86 associated with inflammation and stroke

5) Confidence 0.75 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.57 Pain Relevance 0.25

We could not see any difference in T cell population, in regards to both CD4:CD8 ratio and expression of CD86 (B7.2) on T cells.

Gene_expression (expression) of B7.2 in T cells

6) Confidence 0.75 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.19 Pain Relevance 0.06

KP at 5% or 10% clearly decreased the PCl-augmented expression of major histocompatibility complex class II and CD86 on LCs.

Gene_expression (expression) of CD86 in CD86

7) Confidence 0.67 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18565185 Disease Relevance 0 Pain Relevance 0

After blocking Fc receptors, using 24.G2 (from our hybridoma collection), cells were stained with the following antibodies (BD PharMingen); PE conjugated anti-B7.1 (clone 16-10A1), FITC conjugated anti-B7.2 (GL1), cytochrome conjugated anti-B220 (RA3-6B2), APC conjugated anti-Thy1.2 (53-2.1), PE conjugated anti-CD4 (H129.19), cytochrome conjugated anti-CD8 (53-6.7).

Neg (blocking) Gene_expression (blocking) of B7.2 in GL1

8) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.05 Pain Relevance 0.03

CpG-ODN, a known potent DC stimulator, induced the highest level of IL-12p70 production while only moderately increasing IL-10 production, and significantly enhanced the expression of CD80 and CD86, indicating CpG-ODN induced immature DC towards a mature phenotype.

Gene_expression (expression) of CD86 in CD86

9) Confidence 0.64 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.49 Pain Relevance 0.04

More importantly, 55°C-HIFU-treated tumor cells showed much more potent immunostimulatory activities than 80°C-HIFU-treated ones, both in the induction of IL-12p70 production and in the upregulation of CD80 and CD86 expression.

Gene_expression (expression) of CD86 in CD86 associated with cancer

10) Confidence 0.64 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.84 Pain Relevance 0.07

Normal B16 tumor cells shown no effects on IL-12 p70 production but markedly increased IL-10 production, and significantly decreased the expressions of CD80 and CD86.

Gene_expression (expressions) of CD86 in CD86 associated with cancer

11) Confidence 0.64 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.58 Pain Relevance 0.05

Furthermore, both 55°C-HIFU- and 80°C-HIFU-treated tumor cells significantly enhanced surface expressions of CD80 and CD86 on co-cultured DCs.

Gene_expression (expressions) of CD86 in CD86 associated with cancer

12) Confidence 0.64 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.77 Pain Relevance 0.04

Vaccinated with CpG-ODN induces CD86 expression on B cells in IFN-?

Gene_expression (expression) of CD86 in B cells

13) Confidence 0.61 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.19 Pain Relevance 0.07

We could not see any difference in T cell population, in regards to both CD4:CD8 ratio and expression of CD86 (B7.2) on T cells.

Gene_expression (expression) of CD86 in T cells

14) Confidence 0.61 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.19 Pain Relevance 0.06

However, there was a significant difference in CD86 (B7.2) expression on B cells.

Gene_expression (expression) of CD86 in B cells

15) Confidence 0.61 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.19 Pain Relevance 0.05

In this study, at physiological concentrations, it profoundly inhibited CD40, CD80, CD86, and MHC class II expression on murine, GM-CSF + IL-4 stimulated, bone marrow-derived myeloid dendritic cells (DC).

Gene_expression (expression) of CD86 in myeloid dendritic cells

16) Confidence 0.60 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.10 Pain Relevance 0.31

In cultures pretreated with vitamin C, the levels of both CD80 and CD86 after activation were similar to the control group.

Gene_expression (levels) of CD86 in CD86

17) Confidence 0.59 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0

Vitamin C did not affect the expressions of CD80 and CD86 in activated B cells

Gene_expression (expressions) of CD86 in B cells

18) Confidence 0.59 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0

We observed the expression of both CD80 and CD86 at 72 hours and 48 hours after activation respectively, at the times when their expression normally peaks (Bhatia et al., 2006).

Gene_expression (expression) of CD86 in CD86

19) Confidence 0.59 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0

Contrary to what we expected, vitamin C applied at non-cytotoxic concentrations did not affect either the proliferation of B cells or the surface expression of activation markers, CD80 and CD86 (Fig. 4, 5).

Gene_expression (expression) of CD86 in CD86

20) Confidence 0.59 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0

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