INT96155
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Hyperthermia increases the expression of co-stimulatory molecules such as CD80 and CD86. | |||||||||||||||
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However, there was a significant difference in CD86 (B7.2) expression on B cells. | |||||||||||||||
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Previous reports indicate that the isolated NSPCs express costimulatory molecules, like CD80 (B7.1) and CD86 (B7.2), though their exact functions have not been elucidated. | |||||||||||||||
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Reduced expression of ETC genes is evident in profiles of aging rods, reported here, but this pathway was not identified in previous profiling studies of whole retinas [26], [27]. | |||||||||||||||
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Interestingly, ONO-AE1-259-01 has been suggested to elevate cAMP and inhibit expression of inflammatory molecules such as ICAM-1 and B7.2 (CD86) [28,29], and such inflammatory molecules affect stroke outcomes [30,31]. | |||||||||||||||
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We could not see any difference in T cell population, in regards to both CD4:CD8 ratio and expression of CD86 (B7.2) on T cells. | |||||||||||||||
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KP at 5% or 10% clearly decreased the PCl-augmented expression of major histocompatibility complex class II and CD86 on LCs. | |||||||||||||||
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After blocking Fc receptors, using 24.G2 (from our hybridoma collection), cells were stained with the following antibodies (BD PharMingen); PE conjugated anti-B7.1 (clone 16-10A1), FITC conjugated anti-B7.2 (GL1), cytochrome conjugated anti-B220 (RA3-6B2), APC conjugated anti-Thy1.2 (53-2.1), PE conjugated anti-CD4 (H129.19), cytochrome conjugated anti-CD8 (53-6.7). | |||||||||||||||
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CpG-ODN, a known potent DC stimulator, induced the highest level of IL-12p70 production while only moderately increasing IL-10 production, and significantly enhanced the expression of CD80 and CD86, indicating CpG-ODN induced immature DC towards a mature phenotype. | |||||||||||||||
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More importantly, 55°C-HIFU-treated tumor cells showed much more potent immunostimulatory activities than 80°C-HIFU-treated ones, both in the induction of IL-12p70 production and in the upregulation of CD80 and CD86 expression. | |||||||||||||||
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Normal B16 tumor cells shown no effects on IL-12 p70 production but markedly increased IL-10 production, and significantly decreased the expressions of CD80 and CD86. | |||||||||||||||
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Furthermore, both 55°C-HIFU- and 80°C-HIFU-treated tumor cells significantly enhanced surface expressions of CD80 and CD86 on co-cultured DCs. | |||||||||||||||
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Vaccinated with CpG-ODN induces CD86 expression on B cells in IFN-? | |||||||||||||||
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We could not see any difference in T cell population, in regards to both CD4:CD8 ratio and expression of CD86 (B7.2) on T cells. | |||||||||||||||
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However, there was a significant difference in CD86 (B7.2) expression on B cells. | |||||||||||||||
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In this study, at physiological concentrations, it profoundly inhibited CD40, CD80, CD86, and MHC class II expression on murine, GM-CSF + IL-4 stimulated, bone marrow-derived myeloid dendritic cells (DC). | |||||||||||||||
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In cultures pretreated with vitamin C, the levels of both CD80 and CD86 after activation were similar to the control group. | |||||||||||||||
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Vitamin C did not affect the expressions of CD80 and CD86 in activated B cells | |||||||||||||||
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We observed the expression of both CD80 and CD86 at 72 hours and 48 hours after activation respectively, at the times when their expression normally peaks (Bhatia et al., 2006). | |||||||||||||||
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Contrary to what we expected, vitamin C applied at non-cytotoxic concentrations did not affect either the proliferation of B cells or the surface expression of activation markers, CD80 and CD86 (Fig. 4, 5). | |||||||||||||||
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