INT96156

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 144
Total Number 147
Disease Relevance 56.95
Pain Relevance 21.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
microglial cells 24
T cells 18
CD86 17
B cells 6
monocytes 5
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 93 100.00 Very High Very High Very High
Nerve growth factor 49 100.00 Very High Very High Very High
agonist 871 99.92 Very High Very High Very High
Arthritis 474 99.88 Very High Very High Very High
Cannabinoid 319 99.76 Very High Very High Very High
Hippocampus 43 99.68 Very High Very High Very High
cytokine 1157 98.96 Very High Very High Very High
Inflammation 1613 98.88 Very High Very High Very High
Pain 69 98.80 Very High Very High Very High
Cannabinoid receptor 145 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 205 100.00 Very High Very High Very High
Necrosis 155 100.00 Very High Very High Very High
Infection 867 99.88 Very High Very High Very High
Experimental Arthritis 184 99.88 Very High Very High Very High
Eye Disease 126 99.80 Very High Very High Very High
Diabetes Mellitus 47 99.60 Very High Very High Very High
Influenza Virus Infection 169 99.36 Very High Very High Very High
Drug Induced Neurotoxicity 33 99.36 Very High Very High Very High
Respiratory Syncytial Virus 80 99.28 Very High Very High Very High
Encephalitis 24 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since CTLA4-Ig mediated co-stimulatory blockade induces remission of autoimmunity, we sought to determine whether a temporary suppression of CD40 expression by administration of siRNA may induce immune modulatory effects on RA that predispose towards reduction of immunity towards the autoantigen.
Gene_expression (expression) of CD40 associated with autoimmune disease and rheumatoid arthritis
1) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.63 Pain Relevance 0.18
It is recognized that CD40 is expressed by B cells, macrophages, and some T cells.
Gene_expression (expressed) of CD40 in T cells
2) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.45 Pain Relevance 0
First, B cells may drive synovial inflammation by production of autoantibodies;20 they are the precursors of short-lived plasma cells associated with production of autoantibodies, such as IgM-RF and ACPA.
Gene_expression (production) of IgM in plasma cells associated with inflammation
3) Confidence 0.75 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0.60 Pain Relevance 0.39
CD40 receptor, a member of TNF and nerve growth factor super-family, is expressed on many professional and non-professional APCs, including DC's, B cells, monocytes/M?
Gene_expression (expressed) of CD40 receptor in B cells associated with nerve growth factor
4) Confidence 0.71 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.90 Pain Relevance 0.13
In that report, the authors showed that CD40 expression by parenchymal microglia was responsible for recruitment/retention of encephalitogenic T cells in EAE.
Gene_expression (expression) of CD40 in microglia associated with multiple sclerosis
5) Confidence 0.71 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.80 Pain Relevance 0.11
-induced CD40 expression in a dose-related manner (Figure. 1B).
Gene_expression (expression) of CD40
6) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.09
signaling pathway to induce microglial CD40 expression and subsequent neurotoxicity [28].
Gene_expression (expression) of CD40 associated with drug induced neurotoxicity
7) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.80 Pain Relevance 0.31
CD40-expressing) were calculated as follows: for each treatment, the mean fluorescence value for the isotype-matched control antibody was subtracted from the mean fluorescence value for the CD40-specific antibody.


Gene_expression (expressing) of CD40
8) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.09 Pain Relevance 0.03
peptide and enhanced CD40 expression on microglial cells derived from the Tg2576 mouse model of AD [28].
Gene_expression (expression) of CD40 in microglial cells associated with disease
9) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.78 Pain Relevance 0.29
To examine the functional consequences of CB2 agonist treatment on CD40 expression, we stimulated mouse primary microglial cells with either IFN-?
Gene_expression (expression) of CD40 in microglial cells associated with agonist
10) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.19 Pain Relevance 0.22
As expected, the treatment of cultured microglial cells with THC, CP55940 and JWH-015 significantly inhibited CD40 expression induced by IFN-?
Gene_expression (expression) of CD40 in microglial cells
11) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.09
(100 U/ml) in the presence or absence of THC, CP55940 or JWH-015 for 12 hr and the expression of CD40 was analyzed by flow cytometry.
Gene_expression (expression) of CD40
12) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.09
A review of the molecular basis of CD40 expression in macrophages/microglial cells illuminates the critical role of the JAK/STAT1 pathway [55].
Gene_expression (expression) of CD40 in microglial cells
13) Confidence 0.70 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.78 Pain Relevance 0.28
Flow cytometric analysis of microglial CD40 expression
Gene_expression (expression) of CD40
14) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0 Pain Relevance 0
Further, to determine if this reduction in CD40 expression continues through microglial activation, we treated both N9 and primary microglia cells with 25 ?
Gene_expression (expression) of CD40 in microglia
15) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.17 Pain Relevance 0
To establish the mechanism whereby apigenin and luteolin decrease CD40 expression on the microglial cell surface, we investigated the upstream STAT1 signaling pathway.
Gene_expression (expression) of CD40 in microglial cell
16) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.17 Pain Relevance 0.12
M may be the most efficacious concentration for regulating CD40 expression (Fig. 2C and 2D).
Gene_expression (expression) of CD40
17) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.18 Pain Relevance 0
One such flavonoid, apigenin, and its phase I metabolite, luteolin, have been found to reduce CD40 and CD40L expression on dendritic cells and basophils, respectively [43,44].
Gene_expression (expression) of CD40 in basophils
18) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.65 Pain Relevance 0.30
-induced microglial CD40 expression [25,26].
Gene_expression (expression) of CD40
19) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.68 Pain Relevance 0.25
Despite promising preclinical data, translation of CD40/154 blockade approaches has proved difficult due to the expression of CD154 on platelets, which causes risk of thromboembolic events.
Gene_expression (expression) of CD40 in platelets associated with cva
20) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.83 Pain Relevance 0.31

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