INT96157

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 74
Total Number 85
Disease Relevance 31.19
Pain Relevance 9.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 44
T cells 10
B cells 8
DCs 2
lung 2
Cd80 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 719 99.52 Very High Very High Very High
cytokine 737 99.08 Very High Very High Very High
rheumatoid arthritis 175 99.04 Very High Very High Very High
Neuritis 20 99.04 Very High Very High Very High
abatacept 35 98.92 Very High Very High Very High
chemokine 169 97.38 Very High Very High Very High
tolerance 98 96.64 Very High Very High Very High
Analgesic 1 95.72 Very High Very High Very High
Multiple sclerosis 99 95.48 Very High Very High Very High
aspirin 11 94.28 High High
Disease Link Frequency Relevance Heat
Infection 980 99.88 Very High Very High Very High
Candida Infection 685 99.70 Very High Very High Very High
Fever 44 99.70 Very High Very High Very High
INFLAMMATION 714 99.52 Very High Very High Very High
Cancer 1296 99.24 Very High Very High Very High
Rheumatoid Arthritis 177 99.04 Very High Very High Very High
Experimental Autoimmune Neuritis 20 99.04 Very High Very High Very High
Multiple Sclerosis 324 98.96 Very High Very High Very High
Adhesions 39 98.80 Very High Very High Very High
Diabetes Mellitus 137 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyperthermia increases the expression of co-stimulatory molecules such as CD80 and CD86.
Gene_expression (expression) of CD80 in CD86 associated with fever
1) Confidence 0.77 Published 2006 Journal Vaccine Section Abstract Doc Link 16735086 Disease Relevance 1.10 Pain Relevance 0.18
The antigen-presenting capacity of SCs was assessed by the expression of MHC class II (MHCII), CD40, CD80 and CD86 molecules on activated SCs as well as by induction of T cell proliferation in co-cultures of P0 protein peptide 106-125 specific T cells with activated SCs.
Gene_expression (expression) of CD80 in SCs
2) Confidence 0.64 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20035831 Disease Relevance 0.89 Pain Relevance 0.65
In parallel, the expression of MHCII, CD80 and iNOS on SCs were decreased in TNFR1(-/-) mice compared to wild type mice.
Gene_expression (expression) of CD80 in SCs
3) Confidence 0.64 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20035831 Disease Relevance 1.00 Pain Relevance 0.93
More importantly, 55°C-HIFU-treated tumor cells showed much more potent immunostimulatory activities than 80°C-HIFU-treated ones, both in the induction of IL-12p70 production and in the upregulation of CD80 and CD86 expression.
Gene_expression (expression) of CD80 in CD86 associated with cancer
4) Confidence 0.61 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.85 Pain Relevance 0.07
CpG-ODN, a known potent DC stimulator, induced the highest level of IL-12p70 production while only moderately increasing IL-10 production, and significantly enhanced the expression of CD80 and CD86, indicating CpG-ODN induced immature DC towards a mature phenotype.
Gene_expression (expression) of CD80 in CD86
5) Confidence 0.61 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.49 Pain Relevance 0.04
Normal B16 tumor cells shown no effects on IL-12 p70 production but markedly increased IL-10 production, and significantly decreased the expressions of CD80 and CD86.
Gene_expression (expressions) of CD80 in CD86 associated with cancer
6) Confidence 0.61 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.58 Pain Relevance 0.05
Furthermore, both 55°C-HIFU- and 80°C-HIFU-treated tumor cells significantly enhanced surface expressions of CD80 and CD86 on co-cultured DCs.
Gene_expression (expressions) of CD80 in CD86 associated with cancer
7) Confidence 0.61 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.77 Pain Relevance 0.04
In this study, at physiological concentrations, it profoundly inhibited CD40, CD80, CD86, and MHC class II expression on murine, GM-CSF + IL-4 stimulated, bone marrow-derived myeloid dendritic cells (DC).
Gene_expression (expression) of CD80 in myeloid dendritic cells
8) Confidence 0.60 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.10 Pain Relevance 0.31
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Gene_expression (expression) of CD80 in B cells
9) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
Internalization did not significantly alter morphology, lead to clumping, or affect the surface expression patterns of isolated B cells as assessed by the measurement of CD40, CD80, CD86 and MHC II expression by immunostaining and flow cytometry.
Gene_expression (expression) of CD80 in B cells
10) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.20 Pain Relevance 0.11
It was found that LPS mediated a similar increase in the expression of CD40, CD80, CD86 and MHC II for both SPIO-labeled and unlabeled B cells (Fig. 1E).
Gene_expression (expression) of CD80 in B cells
11) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.06 Pain Relevance 0.15
We observed the expression of both CD80 and CD86 at 72 hours and 48 hours after activation respectively, at the times when their expression normally peaks (Bhatia et al., 2006).
Gene_expression (expression) of CD80 in CD86
12) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Similarly, oxidant generating enzyme inhibitors, such as diphenyleneiodonium and allopurinol, suppressed high expression of MHC class II, CD40, and CD80 in rat Kupffer cells after antigen challenge (Maemura et al., 2005).
Gene_expression (expression) of CD80 in Kupffer cells
13) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
To summarize, vitamin C did not affect proliferation, or CD80 and CD86 expression in cultures of activated B cells.
Gene_expression (expression) of CD80 in B cells
14) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0.08
Vitamin C did not affect the expressions of CD80 and CD86 in activated B cells
Gene_expression (expressions) of CD80 in B cells
15) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Contrary to what we expected, vitamin C applied at non-cytotoxic concentrations did not affect either the proliferation of B cells or the surface expression of activation markers, CD80 and CD86 (Fig. 4, 5).
Gene_expression (expression) of CD80 in CD86
16) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
In cultures pretreated with vitamin C, the levels of both CD80 and CD86 after activation were similar to the control group.
Gene_expression (levels) of CD80 in CD86
17) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Pretreatment with vitamin C in the safe range did not affect either proliferation of cultured B cells or the expression of CD80 and CD86 in those cells.
Gene_expression (expression) of CD80 in CD86
18) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998772 Disease Relevance 0.08 Pain Relevance 0
Meanwhile, the co-stimulatory molecules CD40 and CD86 were also upregulated by E2 and CpG separately or together, but the effect of E2 on CD80 expression was minimal compared with CD40 and CD86.
Gene_expression (expression) of CD80 in CD86
19) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.28 Pain Relevance 0
CD80 expression was also detected but the change was not very obviously.
Gene_expression (expression) of CD80
20) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.11 Pain Relevance 0

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