INT96164

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 10.99
Pain Relevance 6.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)
Anatomy Link Frequency
neurons 2
synovial fluid 1
smooth muscle 1
pore 1
interneurons 1
CA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
spinal inflammation 258 99.84 Very High Very High Very High
Inflammation 33 99.68 Very High Very High Very High
amygdala 8 99.48 Very High Very High Very High
Chronic pancreatitis 12 99.24 Very High Very High Very High
Dynorphin 8 99.06 Very High Very High Very High
Hippocampus 27 98.84 Very High Very High Very High
Osteoarthritis 108 98.60 Very High Very High Very High
rheumatoid arthritis 115 98.28 Very High Very High Very High
ischemia 38 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Low Back Pain 255 99.84 Very High Very High Very High
INFLAMMATION 57 99.68 Very High Very High Very High
Stress 429 99.46 Very High Very High Very High
Pancreatitis 13 99.24 Very High Very High Very High
Disease 174 98.84 Very High Very High Very High
Frailty 114 98.60 Very High Very High Very High
Rheumatoid Arthritis 115 98.28 Very High Very High Very High
Epilepsy 9 97.68 Very High Very High Very High
Hypergammaglobulinemia 1 97.60 Very High Very High Very High
Hypoxia 6 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CA1 levels were significantly elevated in AS fluids as compared with the OA samples (p = 0.032).
Positive_regulation (elevated) of CA1 associated with spinal inflammation and osteoarthritis
1) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.59 Pain Relevance 1.08
Furthermore, the ELISA detected higher levels of CA1 in the synovial fluid from patients with AS compared to the OA samples.
Positive_regulation (levels) of CA1 in synovial fluid associated with spinal inflammation and osteoarthritis
2) Confidence 0.48 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.91 Pain Relevance 1.22
Kappa opioid (dynorphin) agonists prevented the behavioural and electroencephalographic seizures produced by convulsant compounds, and these effects were associated with an absence of dynorphin from the dentate gyrus granule cell layer and upregulation of enkephalin in CA1 interneurons, thus reproducing a neurochemical marker of epilepsy, namely low dynorphin tone.
Positive_regulation (upregulation) of CA1 in interneurons associated with epilepsy, convulsion, dynorphin, agonist, enkephalin and opioid
3) Confidence 0.47 Published 2006 Journal Brain Section Abstract Doc Link 16399805 Disease Relevance 1.23 Pain Relevance 0.86
In the hippocampus, the MPT pore can be more readily activated upon calcium induction in CA1 than in CA3 (Mattiasson et al., 2003a).
Positive_regulation (induction) of CA1 in pore associated with hippocampus
4) Confidence 0.41 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.74 Pain Relevance 0.16
Thirty-five of the AS samples (87.5%) had relatively high levels of CA1 (O.D. > 2.0).
Positive_regulation (levels) of CA1 associated with spinal inflammation
5) Confidence 0.39 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.66 Pain Relevance 1.14
This pattern of selective sensitivity of CA1 neurons to OS matches that of selective vulnerability of CA1 neurons to other adverse or disease-related conditions, such as hypoxia, ischemia, and neurodegeneration in AD.
Positive_regulation (vulnerability) of CA1 in neurons associated with stress, hypoxia, ischemia and disease
6) Confidence 0.30 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.14 Pain Relevance 0.23
Nqo1 is one of the target genes of the key anti-oxidant transcription factor Nrf2, which is also significantly more active in CA1 neurons (Wang et al., 2005).
Positive_regulation (active) of CA1 in neurons
7) Confidence 0.28 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.51 Pain Relevance 0
Furthermore, caspase-3 activity was increased in the CA1, DG, LA and MA.
Positive_regulation (increased) of CA1 associated with amygdala
8) Confidence 0.18 Published 2009 Journal Apoptosis Section Abstract Doc Link 19728097 Disease Relevance 0.68 Pain Relevance 0.50
Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action.
Positive_regulation (increase) of anhydrase I in smooth muscle
9) Confidence 0.05 Published 2001 Journal Drugs Exp Clin Res Section Title Doc Link 11392054 Disease Relevance 0 Pain Relevance 0.10
Elevated serum levels of both anti-CA-I (24%) and -CA-II (18%) Abs were observed in CP, although their prevalence was lower than in autoimmune diseases like rheumatoid arthritis (44 and 25%, respectively) or systemic lupus erythematosus (39% for anti-CA-I Abs).
Positive_regulation (Elevated) of CA-I associated with autoimmune disease, rheumatoid arthritis, systemic lupus erythematosus and chronic pancreatitis
10) Confidence 0.02 Published 2002 Journal ScientificWorldJournal Section Abstract Doc Link 12806141 Disease Relevance 1.54 Pain Relevance 0.94

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