INT96200

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 0.79
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (PGP)
Anatomy Link Frequency
endothelial cells 2
nerve 2
neuronal 1
horn 1
brain 1
PGP (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 85 99.98 Very High Very High Very High
Pain 144 97.52 Very High Very High Very High
Bioavailability 75 84.52 Quite High
palliative 1 76.68 Quite High
antagonist 17 75.00 Quite High
Analgesic 13 75.00 Quite High
Taxol 1 69.92 Quite High
Pain score 8 54.00 Quite High
Sciatica 5 39.44 Quite Low
Chronic low back pain 45 38.88 Quite Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 96.16 Very High Very High Very High
Cancer 12 90.40 High High
Disease 6 86.40 High High
Pain 101 53.72 Quite High
Neuropathic Pain 59 50.00 Quite Low
Nociception 34 43.28 Quite Low
Nerve Root Compression 5 39.44 Quite Low
Low Back Pain 65 38.88 Quite Low
Leukemia 2 32.16 Quite Low
Death 5 25.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Treatment of patients with several drugs simultaneously may result in modulation of the naturally expressed P-glycoprotein (Pgp) at different tissues.
Gene_expression (expressed) of Pgp
1) Confidence 0.76 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11396174 Disease Relevance 0 Pain Relevance 0.11
MATERIALS AND METHODS: Human blood brain barrier endothelial cells and human colon adenocarcinoma cells were transduced or transfected with the multidrug resistance gene (MDR1) to express Pgp.
Gene_expression (express) of Pgp in endothelial cells
2) Confidence 0.76 Published 2001 Journal Anticancer Res. Section Body Doc Link 11396174 Disease Relevance 0 Pain Relevance 0
The human multidrug resistance gene 1 (MDR1) is associated with expression of p-glycoprotein (Pgp).
Gene_expression (expression) of Pgp
3) Confidence 0.64 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 14567978 Disease Relevance 0.49 Pain Relevance 0.08
Cremophor EL may inhibit PGP (p-glycoprotein), a relevant efflux pump which is expressed in high amount in gut, biliary tract and the blood brain barrier, and enzymes like CYP3A which may contribute to first pass metabolism.
Gene_expression (expressed) of PGP in brain
4) Confidence 0.13 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374933 Disease Relevance 0 Pain Relevance 0.15
Another area in which the search for definite answers continues, is the quest to find the active constituents of grapefruit juice that are responsible for its actions on CYP enzyme systems and Pgp.
Gene_expression (actions) of Pgp
5) Confidence 0.08 Published 2007 Journal Nutr J Section Body Doc Link PMC2147024 Disease Relevance 0 Pain Relevance 0
There was a strong correlation between numbers of nerve fibres immunostaining for PGP 9.5 and TRPV1 (rs = 0.6049, p < 0.0001).
Gene_expression (immunostaining) of PGP in nerve
6) Confidence 0.04 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1959239 Disease Relevance 0.15 Pain Relevance 0.05
There was a strong correlation between numbers of nerve fibres immunostaining for PGP 9.5 and TRPV1 (rs = 0.6049, p < 0.0001).
Gene_expression (9.5) of PGP in nerve
7) Confidence 0.04 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1959239 Disease Relevance 0.15 Pain Relevance 0.05
CD31 and PGP9.5 were expressed most highly in degenerate tissues correlating with low expression of sema3A.


Gene_expression (expressed) of PGP9
8) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
Of note, our IHC findings demonstrated an increased PGP9.5 and CD31 expression in the IAF and OAF of the surgical degenerate samples in comparison to the healthy, indicating that more neuronal and endothelial cell types were present in these samples.
Gene_expression (expression) of PGP9 in endothelial cell
9) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0.10
No PGP9.5 expression was observed in any of the samples.


Gene_expression (expression) of PGP9
10) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
Aliqouts of cDNA were subjected to PCR using primers specific for the house-keeping gene GAPDH, as well as sema3A, sema3F, NRP-1, NRP-2, PLXA1, PLXA2, PLXA3, PLXA4 and PGP9.5 (Table 1).
Gene_expression (as) of PGP9
11) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
Of note, our IHC findings demonstrated an increased PGP9.5 and CD31 expression in the IAF and OAF of the surgical degenerate samples in comparison to the healthy, indicating that more neuronal and endothelial cell types were present in these samples.
Gene_expression (expression) of PGP9 in neuronal
12) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0.10
Quantitative analysis showed no difference in the Nav1.7 expression within N52/PGP9.5-identified nerve area or in the pixel intensity of this expression within axons in the pulp horn of normal samples when compared to painful samples (area – 57.6% ± 5.6 vs. 46.6% ± 11.9; Fig. 3A/intensity – 549.6 ± 26.1 vs. 670.8 ± 204.7; Fig. 3B).
Gene_expression (expression) of PGP9 in horn associated with pain and nav1.7
13) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.99

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