INT96210

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.99
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC6A2) plasma membrane (SLC6A2) transmembrane transport (SLC6A2)
Anatomy Link Frequency
synapse 2
SLC6A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 15 99.60 Very High Very High Very High
cocaine 1 98.80 Very High Very High Very High
antidepressant 1 98.32 Very High Very High Very High
monoamine 42 97.88 Very High Very High Very High
Neurotransmitter 41 97.48 Very High Very High Very High
Catecholamine 7 95.04 Very High Very High Very High
Pain 176 94.88 High High
imagery 1 94.00 High High
Analgesic 12 71.28 Quite High
Enkephalin 1 64.96 Quite High
Disease Link Frequency Relevance Heat
Multiple Organ Failure 13 97.90 Very High Very High Very High
Critical Illness 1 96.56 Very High Very High Very High
Disease 6 92.88 High High
Diabetes Mellitus 2 90.56 High High
Pain 184 88.80 High High
Shock 11 78.08 Quite High
Stroke 2 73.12 Quite High
Epilepsy 3 71.20 Quite High
Headache 3 70.44 Quite High
Targeted Disruption 2 40.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: We showed an increased net MMP-2 activity in MWA and MA.
Positive_regulation (increased) of net
1) Confidence 0.49 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 19627981 Disease Relevance 0.21 Pain Relevance 0
Since the re-uptake of monoamine neurotransmitters through specific transporters is the major method of elimination from the neural synapse, it is not surprising that the genetic variations in norepinephrine transporter gene (SLC6A2) and the serotonin transporter gene (SLC6A4) affect monoamine neurotransmitter mediated human behaviors including responses to painful stimuli.
Positive_regulation (variations) of SLC6A2 in synapse associated with pain, neurotransmitter, serotonin and monoamine
2) Confidence 0.47 Published 2006 Journal Mol Pain Section Body Doc Link PMC1543620 Disease Relevance 0.49 Pain Relevance 0.97
Since the re-uptake of monoamine neurotransmitters through specific transporters is the major method of elimination from the neural synapse, it is not surprising that the genetic variations in norepinephrine transporter gene (SLC6A2) and the serotonin transporter gene (SLC6A4) affect monoamine neurotransmitter mediated human behaviors including responses to painful stimuli.
Positive_regulation (variations) of norepinephrine transporter in synapse associated with pain, neurotransmitter, serotonin and monoamine
3) Confidence 0.47 Published 2006 Journal Mol Pain Section Body Doc Link PMC1543620 Disease Relevance 0.49 Pain Relevance 0.96
We prospectively enrolled 18 critically ill patients suffering from severe multiple organ dysfunction syndrome following cardiac or major surgery, with a MAP below 65 mmHg despite adequate volume resuscitation, and norepinephrine requirements in excess of 0.5 ?
Positive_regulation (requirements) of norepinephrine associated with multiple organ failure and critical illness
4) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1550871 Disease Relevance 0.73 Pain Relevance 0
Using these methods, Na-dependent, NE+-induced hNET currents that are blocked by cocaine and antidepressants, channel modes of NE+ conduction, voltage-dependent uptake coupled to NE+-induced ion channel activity, PKC (phosphokinase C) regulation of NE+ uptake, and transporter modulation by [Ca2+]i have all been discovered.
Positive_regulation (induced) of hNET associated with antidepressant and cocaine
5) Confidence 0.01 Published 2001 Journal Mol. Membr. Biol. Section Abstract Doc Link 11396611 Disease Relevance 0.06 Pain Relevance 0.41

General Comments

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