INT96214

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Context Info
Confidence 0.63
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 16.99
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TCEAL1)
Anatomy Link Frequency
lung 2
liver 1
skin 1
TCEAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 7 97.08 Very High Very High Very High
Osteoarthritis 36 96.48 Very High Very High Very High
COX-2 inhibitor 19 95.52 Very High Very High Very High
cytokine 65 94.00 High High
Inflammation 45 93.60 High High
rheumatoid arthritis 74 89.24 High High
cINOD 13 82.32 Quite High
metalloproteinase 74 50.00 Quite Low
Inflammatory mediators 10 36.72 Quite Low
methotrexate 4 33.36 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 106 100.00 Very High Very High Very High
Cancer 340 99.50 Very High Very High Very High
Lung Cancer 21 99.16 Very High Very High Very High
Esophageal Cancer 83 98.18 Very High Very High Very High
Pancreatic Cancer 148 98.08 Very High Very High Very High
Shock 2 97.44 Very High Very High Very High
Skin Cancer 23 97.28 Very High Very High Very High
Frailty 38 96.48 Very High Very High Very High
Osteogenic Sarcomas 4 96.20 Very High Very High Very High
Syndrome 4 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no significant correlation between the expression of HIF-1alpha, p53 and p21 and proliferation and apoptosis.
Gene_expression (expression) of p21 associated with apoptosis
1) Confidence 0.63 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.86 Pain Relevance 0.08
Combined immunohistochemical evaluation of HIF-1alpha, p53 and p21 protein expression at the pretreatment biopsy is a very useful and powerful indicator of sensitivity to CRT in human esophageal cancer.
Gene_expression (expression) of p21 associated with esophageal cancer
2) Confidence 0.63 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.68 Pain Relevance 0.10
Nitrosulindac caused a light perturbation of the cell cycle parameters not linked to a modification of the levels of p21 or the proliferating cell nuclear antigen.
Gene_expression (levels) of p21
3) Confidence 0.58 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11396974 Disease Relevance 0.55 Pain Relevance 0.29
HIF-1alpha expression in esophageal cancer was significantly and negatively related to the response to CRT, independently of p53 and p21 expression.
Gene_expression (expression) of p21 associated with esophageal cancer
4) Confidence 0.55 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.99 Pain Relevance 0.07
Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer.
Gene_expression (expression) of p21 associated with esophageal cancer
5) Confidence 0.55 Published 2004 Journal Int. J. Cancer Section Title Doc Link 15170665 Disease Relevance 0.92 Pain Relevance 0
Our aim was to evaluate the expression of the HIF-1alpha, p53 and p21 proteins by immunohistochemistry in biopsy specimens of esophageal squamous cell carcinoma, which were obtained endoscopically from 65 patients before CRT, and then determine whether the levels of expression of these proteins predicted the clinical effectiveness of CRT in individual cancers.
Gene_expression (expression) of p21 associated with cancer and skin cancer
6) Confidence 0.55 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 1.09 Pain Relevance 0
In this study, we investigated particularly the effect of 100 microM NS-398 on p53 and p21 expression, caspase activities and nuclear factor-kappaB (NF-kappaB).
Gene_expression (expression) of p21
7) Confidence 0.42 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 12012007 Disease Relevance 0.75 Pain Relevance 0.16
We found a correlation between p53, p21 mRNA expression and NF-kappaB activation and, we observed an induction of heat shock protein 70 expression with a large decrease in caspase-3 activity after 100 microM NS-398 treatment.
Gene_expression (expression) of p21 associated with shock
8) Confidence 0.37 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 12012007 Disease Relevance 0.75 Pain Relevance 0.15
Conversely another Japanese group found that whilst p21 positive expression in the absence of p53 was associated with favourable effects from preoperative chemotherapy there was no such correlation between p21 expression and the clinical effects following CRT [29,30].


Gene_expression (expression) of p21
9) Confidence 0.21 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1999497 Disease Relevance 0.62 Pain Relevance 0
Conversely another Japanese group found that whilst p21 positive expression in the absence of p53 was associated with favourable effects from preoperative chemotherapy there was no such correlation between p21 expression and the clinical effects following CRT [29,30].


Gene_expression (expression) of p21
10) Confidence 0.21 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1999497 Disease Relevance 0.64 Pain Relevance 0
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
Gene_expression (expression) of p21 in lung associated with cancer
11) Confidence 0.19 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.46 Pain Relevance 0
DMSO exerts this effect ultimately by increasing the expression of p27 whereas ATRA upregulates the expression of p21.
Gene_expression (expression) of p21
12) Confidence 0.18 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0 Pain Relevance 0
The mode of action may be twofold: enhancing expression of mitogenic functions (e.g., immediate growth response genes) and the reduced expression of cell cycle arresting proteins (p21 and p27) [14,35].
Gene_expression (expression) of p21
13) Confidence 0.15 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.39 Pain Relevance 0.24
Recently, LKB1 was reported to induce p21 expression in collaboration with LMO4 [34].
Gene_expression (expression) of p21
14) Confidence 0.14 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.88 Pain Relevance 0
Increasing the expression of some pro-apoptotic proteins, such as TRAIL and p21, has been shown to be one of the molecular mechanisms by which the HDAC inhibitors induce cancer cell death [46,47].
Gene_expression (expression) of p21 associated with cancer, apoptosis and death
15) Confidence 0.11 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 1.31 Pain Relevance 0
Both NS-398 and nimesulide induced p21 gene promoter activity in non-small cell lung cancer cells but COX-2 siRNA did not affect the expression of p21 [35].
Gene_expression (expression) of p21 in lung associated with lung cancer
16) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.92 Pain Relevance 0.15
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
Gene_expression (expression) of p21 in liver associated with cancer
17) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.46 Pain Relevance 0
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
Gene_expression (expression) of p21 in skin associated with cancer
18) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.46 Pain Relevance 0
Knockdown of HDAC1 and HDAC2 by siRNA resulted in increased expression of p16, p21, and p53, and decreased cell counts and cell proliferation, and increased apoptosis in RASF.
Gene_expression (expression) of p21 associated with apoptosis
19) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.24 Pain Relevance 0.42

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