INT96218

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 5.23
Pain Relevance 6.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleus (Pgr) enzyme binding (Pgr)
DNA binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
uterine 5
mammary glands 1
neurons 1
oral epithelium 1
skin 1
Pgr (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 3 99.68 Very High Very High Very High
Paracetamol 55 99.54 Very High Very High Very High
withdrawal 6 98.76 Very High Very High Very High
antinociception 2 98.26 Very High Very High Very High
endometriosis 16 98.02 Very High Very High Very High
Thermal hyperalgesia 1 94.12 High High
allodynia 1 93.12 High High
Enkephalin 6 90.92 High High
antagonist 2 90.48 High High
substance P 6 90.32 High High
Disease Link Frequency Relevance Heat
Endometriosis 11 98.02 Very High Very High Very High
Skin Cancer 8 97.32 Very High Very High Very High
Targeted Disruption 28 96.76 Very High Very High Very High
Sprains And Strains 100 95.92 Very High Very High Very High
Disease 14 95.84 Very High Very High Very High
Hyperplasia 8 95.48 Very High Very High Very High
Hyperalgesia 2 94.12 High High
Neuropathic Pain 3 93.12 High High
Nervous System Injury 3 91.96 High High
Premature Birth 162 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Markers of estrogenic activity examined were uterine weight, uterine peroxidase activity and progesterone receptor (PR) up-regulation.
Positive_regulation (up-regulation) of progesterone receptor in uterine
1) Confidence 0.68 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11397560 Disease Relevance 0.08 Pain Relevance 0.78
Markers of estrogenic activity examined were uterine weight, uterine peroxidase activity and progesterone receptor (PR) up-regulation.
Positive_regulation (up-regulation) of PR in uterine
2) Confidence 0.68 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11397560 Disease Relevance 0.08 Pain Relevance 0.78
The results demonstrated that, at all three doses, acetaminophen did not significantly increase uterine weight, uterine peroxidase activity or PR levels.
Neg (not) Positive_regulation (increase) of PR in uterine associated with paracetamol
3) Confidence 0.68 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11397560 Disease Relevance 0.07 Pain Relevance 0.91
Our finding suggests that progesterone resistance in endometriosis in general and the down regulation of PR-B, but not PR-A, in particular, are a result of promoter hypermethylation of PR-B, but not PR-A.
Positive_regulation (hypermethylation) of PR-B associated with endometriosis
4) Confidence 0.43 Published 2006 Journal Epigenetics : official journal of the DNA Methylation Society Section Abstract Doc Link 17965625 Disease Relevance 0.99 Pain Relevance 0.44
However, the co-administration of E(2) and acetaminophen (200 mg/kg per day, 3 days, i.p.) resulted in a decrease in the E(2)-induced upregulation of uterine and hepatic nuclear PR (uterine PR values of 39.7+/-6.6 and 23.7+/-3.4 fmol/mg for E(2)+vehicle and E(2)+acetaminophen, respectively, P<0.05).
Positive_regulation (upregulation) of PR in uterine associated with paracetamol
5) Confidence 0.40 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11397560 Disease Relevance 0.07 Pain Relevance 0.93
However, the co-administration of E(2) and acetaminophen (200 mg/kg per day, 3 days, i.p.) resulted in a decrease in the E(2)-induced upregulation of uterine and hepatic nuclear PR (uterine PR values of 39.7+/-6.6 and 23.7+/-3.4 fmol/mg for E(2)+vehicle and E(2)+acetaminophen, respectively, P<0.05).
Positive_regulation (upregulation) of PR in uterine associated with paracetamol
6) Confidence 0.40 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11397560 Disease Relevance 0.07 Pain Relevance 0.93
In addition, virgin BALB/c mammary glands expressed higher levels of PR-A and ER-?
Positive_regulation (levels) of PR in mammary glands
7) Confidence 0.38 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.34 Pain Relevance 0
overexpression, increased PR levels were also observed.
Positive_regulation (increased) of PR
8) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.64 Pain Relevance 0
Next we tested whether the PK11195-induced antinociception is attributable to reduced neurosteroid synthesis, which may possibly lead to reduced activation of the progesterone receptor and/or GABA(A) receptor.
Positive_regulation (activation) of progesterone receptor associated with antinociception and gaba
9) Confidence 0.26 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19403993 Disease Relevance 0.67 Pain Relevance 0.78
Binding of progesterone to PR-A, the short form of the receptor, not thought to be associated with intra-cellular pathway mechanisms, prevents the actions of progesterone mediated by PR-B.71 An increase in the myometrial PR-A to PR-B expression ratio occurs at the onset of labor at term, resulting in an increase in myometrial PR-A, and in effect a functional withdrawal of progesterone,71,72 with increasing sensitivity to contractile stimuli.65,67,73,74 Prostaglandins produced prior to the onset of labor, also act to increase the PR-A/PR-B expression ratio, and therefore the potential to initiate a functional withdrawal of progesterone.67 In many animals the onset of labor is associated with a decrease in progesterone concentrations,62,64,65,75 but this has not been shown to occur in women before term or preterm birth, with no apparently detectable changes to circulating steroid hormone levels evident.64,65,67,76,77

Progesterone as an anti-inflammatory agent

Positive_regulation (increase) of PR associated with inflammation, premature birth and withdrawal
10) Confidence 0.26 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971700 Disease Relevance 0.41 Pain Relevance 0.17
Binding of progesterone to PR-A, the short form of the receptor, not thought to be associated with intra-cellular pathway mechanisms, prevents the actions of progesterone mediated by PR-B.71 An increase in the myometrial PR-A to PR-B expression ratio occurs at the onset of labor at term, resulting in an increase in myometrial PR-A, and in effect a functional withdrawal of progesterone,71,72 with increasing sensitivity to contractile stimuli.65,67,73,74 Prostaglandins produced prior to the onset of labor, also act to increase the PR-A/PR-B expression ratio, and therefore the potential to initiate a functional withdrawal of progesterone.67 In many animals the onset of labor is associated with a decrease in progesterone concentrations,62,64,65,75 but this has not been shown to occur in women before term or preterm birth, with no apparently detectable changes to circulating steroid hormone levels evident.64,65,67,76,77

Progesterone as an anti-inflammatory agent

Positive_regulation (increase) of PR associated with inflammation, premature birth and withdrawal
11) Confidence 0.26 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971700 Disease Relevance 0.26 Pain Relevance 0.13
Binding of progesterone to PR-A, the short form of the receptor, not thought to be associated with intra-cellular pathway mechanisms, prevents the actions of progesterone mediated by PR-B.71 An increase in the myometrial PR-A to PR-B expression ratio occurs at the onset of labor at term, resulting in an increase in myometrial PR-A, and in effect a functional withdrawal of progesterone,71,72 with increasing sensitivity to contractile stimuli.65,67,73,74 Prostaglandins produced prior to the onset of labor, also act to increase the PR-A/PR-B expression ratio, and therefore the potential to initiate a functional withdrawal of progesterone.67 In many animals the onset of labor is associated with a decrease in progesterone concentrations,62,64,65,75 but this has not been shown to occur in women before term or preterm birth, with no apparently detectable changes to circulating steroid hormone levels evident.64,65,67,76,77

Progesterone as an anti-inflammatory agent

Positive_regulation (increase) of PR associated with inflammation, premature birth and withdrawal
12) Confidence 0.26 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971700 Disease Relevance 0.37 Pain Relevance 0.12
Our laboratory previously used a series of keratin-driven, RU486-inducible Cre recombinase-progesterone receptor (PR) fusion proteins for genetic manipulation in the skin and oral epithelium 20, 21.
Positive_regulation (inducible) of recombinase-progesterone receptor in oral epithelium
13) Confidence 0.11 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0.38 Pain Relevance 0
The upregulation of PR-B and AR may be responsible for antiproliferative effects induced by TSA, a histone deacetylase inhibitor (HDACI).
Positive_regulation (upregulation) of PR-B
14) Confidence 0.04 Published 2006 Journal Gynecol. Obstet. Invest. Section Body Doc Link 16778450 Disease Relevance 0 Pain Relevance 0
Our laboratory previously used a series of keratin-driven, RU486-inducible Cre recombinase-progesterone receptor (PR) fusion proteins for genetic manipulation in the skin and oral epithelium 20, 21.
Positive_regulation (inducible) of recombinase-progesterone receptor in skin
15) Confidence 0.04 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0.38 Pain Relevance 0
Along with the NeuN-immunohistochemistry, our results suggest that induction of CrePR-mediated DTA expression by RU-486 injection successfully ablated almost completely the medium spiny neurons that comprise approximately 90% of the NeuN-positive striatal neurons within 13 days.
Positive_regulation (induction) of CrePR in neurons
16) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613534 Disease Relevance 0.06 Pain Relevance 0.46
Induction of CrePR recombinase activity
Positive_regulation (Induction) of CrePR
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613534 Disease Relevance 0.22 Pain Relevance 0.13
Gene expression levels for PR-A, PR-B, AR, Fas and FasL were measured.
Positive_regulation (levels) of PR-B
18) Confidence 0.03 Published 2006 Journal Gynecol. Obstet. Invest. Section Body Doc Link 16778450 Disease Relevance 0.09 Pain Relevance 0
PR-A, PR-B, AR, and FasL expression were all increased as compared with untreated cells.
Positive_regulation (increased) of PR-B
19) Confidence 0.03 Published 2006 Journal Gynecol. Obstet. Invest. Section Body Doc Link 16778450 Disease Relevance 0.06 Pain Relevance 0

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