INT96229

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Context Info
Confidence 0.20
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.76
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (HPSE) extracellular region (HPSE) cell adhesion (HPSE)
nucleus (HPSE) carbohydrate metabolic process (HPSE) lysosome (HPSE)
Anatomy Link Frequency
endothelial cells 1
leukocyte 1
HPSE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 29 99.96 Very High Very High Very High
Inflammation 58 99.12 Very High Very High Very High
rheumatoid arthritis 121 96.92 Very High Very High Very High
metalloproteinase 13 82.56 Quite High
depression 19 75.36 Quite High
Hyperalgesia 1 65.20 Quite High
Pain 3 63.76 Quite High
Somatostatin 1 7.76 Low Low
chemokine 28 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 288 99.90 Very High Very High Very High
Schizophrenia 498 99.84 Very High Very High Very High
INFLAMMATION 55 99.12 Very High Very High Very High
Hypersensitivity 2 98.86 Very High Very High Very High
Osteoarthritis 18 97.32 Very High Very High Very High
Rheumatoid Arthritis 121 96.92 Very High Very High Very High
Anxiety Disorder 12 89.36 High High
Disease 40 78.88 Quite High
Depression 31 75.36 Quite High
Psychosis 102 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data published from 1980 onwards on the basis that studies reported before this date did not use control groups for basal measures and most also utilized outdated assay methods to detect levels of HPA secretories which may now be considered inaccurateWritten in EnglishPatients diagnosed with schizophrenia using structured diagnostic interviews such as DSM or RDC criteriaSchizophrenia diagnosed in at least 90% of the reported psychiatric cohort.
Localization (secretories) of HPA associated with schizophrenia
1) Confidence 0.20 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.43 Pain Relevance 0.04
Psychological stress and HPA axis response in schizophrenia
Localization (response) of HPA associated with stress and schizophrenia
2) Confidence 0.20 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.93 Pain Relevance 0
The DST is a test of delayed feedback mechanisms in the HPA axis which may then lead to hypersecretion of cortisol.
Localization (hypersecretion) of HPA
3) Confidence 0.20 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.24 Pain Relevance 0
Other enzymes such as heparanase and plasmin are produced and secreted from endothelial cells.
Localization (secreted) of heparanase in endothelial cells
4) Confidence 0.10 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.87 Pain Relevance 0.58
Through the release of histamine and other mediators and their effects on the mast cell-leukocyte cytokine cascade, immune stimuli in susceptible persons increase allergic inflammation and magnify stressors' effects through the release of HPA-axis-activating cytokines, such as IL-1beta, that drive the axis and reinforce the physiological and behavioral effects.
Localization (release) of HPA-axis-activating in leukocyte associated with inflammation, hypersensitivity and cytokine
5) Confidence 0.01 Published 2001 Journal Med. Hypotheses Section Abstract Doc Link 11399109 Disease Relevance 0.29 Pain Relevance 0.43

General Comments

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