INT96234

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.94
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
macrophages 1
monocytes 1
immune cells 1
lymphocytes 1
Th2 cells 1
Il13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 148 100.00 Very High Very High Very High
chemokine 21 99.60 Very High Very High Very High
Angina 1 99.48 Very High Very High Very High
Inflammation 210 99.32 Very High Very High Very High
Arthritis 396 99.00 Very High Very High Very High
corticosteroid 27 98.56 Very High Very High Very High
Hyperalgesia 5 98.52 Very High Very High Very High
bradykinin 4 95.92 Very High Very High Very High
rheumatoid arthritis 191 95.76 Very High Very High Very High
Pain 8 84.76 Quite High
Disease Link Frequency Relevance Heat
Eosinophilia 2 99.62 Very High Very High Very High
Cv General 3 Under Development 1 99.48 Very High Very High Very High
INFLAMMATION 222 99.32 Very High Very High Very High
Arthritis 384 99.00 Very High Very High Very High
Hypersensitivity 49 98.66 Very High Very High Very High
Hyperalgesia 6 98.52 Very High Very High Very High
Rheumatoid Arthritis 192 95.76 Very High Very High Very High
Disease 94 95.20 Very High Very High Very High
Asthma 220 93.76 High High
Autoimmune Disease 27 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that IL-13, released by lymphocytes, limits inflammatory hyperalgesia by the inhibition of the production TNF-alpha, IL-1 beta, IL-8 and PGs.
Localization (released) of IL-13 in lymphocytes associated with hyperalgesia and inflammation
1) Confidence 0.62 Published 2001 Journal Eur. Cytokine Netw. Section Abstract Doc Link 11399514 Disease Relevance 0.60 Pain Relevance 0.59
AIM: The aim of this study is to investigate the T helper (Th)2-dependent release of interleukin(IL)-4 and IL-13 in patients with unstable angina treated with coronary angioplasty (PCI).
Localization (release) of IL-13 associated with angina
2) Confidence 0.23 Published 2008 Journal Coron. Artery Dis. Section Abstract Doc Link 18418228 Disease Relevance 0.10 Pain Relevance 0.14
, whereas the counter-regulatory Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 [118].
Localization (secrete) of IL-13 in Th2 cells
3) Confidence 0.08 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 1.16 Pain Relevance 0.41
IL-13 inhibits activated monocytes/macrophages from secreting a variety of pro-inflammatory molecules.
Localization (secreting) of IL-13 in macrophages associated with inflammation
4) Confidence 0.07 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.48 Pain Relevance 0.93
In the late-phase allergic response, cytokines such as interleukin (IL)-4, IL-5, IL-6, IL-8, IL-13, and TNF are induced and secreted [30].
Localization (secreted) of IL-13 associated with hypersensitivity and cytokine
5) Confidence 0.07 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.67 Pain Relevance 0.26
Low SF patients (n=8) showed post-ex decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and TNFalpha (p<.05).
Localization (decreases) of IL-13
6) Confidence 0.04 Published 2010 Journal Psychophysiology Section Abstract Doc Link 20230500 Disease Relevance 0.57 Pain Relevance 0.30
that promote a pro-inflammatory environment, while Th2 cytokines secrete cytokines like IL-4, IL-10, and IL-13 that down-regulate Th1 activity.
Localization (secrete) of IL-13 associated with inflammation and cytokine
7) Confidence 0.03 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.45 Pain Relevance 1.04
SEB triggers immune cells to release Th2 cytokines IL-4, IL-5 and IL-13 [14,24-26] and enhances antigen-specific immune responses [19,27].
Localization (release) of IL-13 in immune cells associated with cytokine
8) Confidence 0.03 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1524974 Disease Relevance 1.00 Pain Relevance 0.22
IL-13 inhibits activated monocytes/macrophages from secreting a variety of pro-inflammatory molecules.
Localization (secreting) of IL-13 in monocytes associated with inflammation
9) Confidence 0.02 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.48 Pain Relevance 0.93
Intranasal corticosteroids inhibit both early and late reactions and reduce IgE production and eosinophilia by inhibiting the secretion of cytokines including IL-4, IL-5 and IL-13.
Localization (secretion) of IL-13 associated with corticosteroid, eosinophilia and cytokine
10) Confidence 0.02 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846743 Disease Relevance 0.82 Pain Relevance 0.48
Mediators (including histamine; cysteinyl leukotrienes; interleukin [IL]-4, IL-5, IL-13; regulated on activation, normal T-cell expressed and secreted [RANTES] chemokine; and eotaxin) are expressed in both upper and lower airways [14,15].
Localization (secreted) of IL-13 in upper associated with chemokine
11) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 1.61 Pain Relevance 0.19

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