INT96259

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.01
Pain Relevance 11.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Plcg1) signal transduction (Plcg1) plasma membrane (Plcg1)
lipid metabolic process (Plcg1) cytoplasm (Plcg1) signal transducer activity (Plcg1)
Anatomy Link Frequency
PAG 7
brain 1
Plcg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 72 99.84 Very High Very High Very High
Central grey 13 99.08 Very High Very High Very High
antinociception 56 98.84 Very High Very High Very High
antidepressant 12 98.60 Very High Very High Very High
opioid receptor 46 97.84 Very High Very High Very High
agonist 28 97.60 Very High Very High Very High
Antinociceptive 5 96.64 Very High Very High Very High
fluoxetine 1 89.48 High High
Enkephalin 5 89.44 High High
Intracerebroventricular 2 85.08 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 39 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This up-regulation of PLC gamma 1 by morphine was significantly inhibited by i.c.v. pretreatment with LY294002, indicating that morphine can activate PLC gamma 1 through the stimulation of PI3-Kinase.
Positive_regulation (up-regulation) of PLC gamma 1 associated with morphine
1) Confidence 0.49 Published 2001 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 11400324 Disease Relevance 0 Pain Relevance 1.14
The s.c. injection of morphine produced a marked increase in the level of membrane-bound PLC gamma 1 isoform as compared to that from the saline-treated mice.
Positive_regulation (increase) of PLC gamma 1 associated with morphine
2) Confidence 0.49 Published 2001 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 11400324 Disease Relevance 0 Pain Relevance 1.03
Morphine produced a marked increase in the protein level of membrane-bound PLC gamma 1, and this increase induced by morphine was significantly inhibited by intracerebroventricullar (i.c.v.) pretreatment with PI3K inhibitors at the dosage that suppressed the morphine-induced supraspinal antinociception.
Positive_regulation (increase) of PLC gamma 1 associated with antinociception and morphine
3) Confidence 0.36 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.26 Pain Relevance 1.13
The aim of the present study was to investigate whether in vivo morphine treatment could participate in the activation of phospholipase Cgamma1 (PLCgamma1) isoform in the mouse periaqueductal gray matter (PAG) which can be accompanied by antinociceptive responses induced by morphine.
Positive_regulation (activation) of PLCgamma1 in PAG associated with urological neuroanatomy, antinociceptive, central grey and morphine
4) Confidence 0.31 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.41 Pain Relevance 0.59
The aim of the present study was to investigate whether in vivo morphine treatment could participate in the activation of phospholipase Cgamma1 (PLCgamma1) isoform in the mouse periaqueductal gray matter (PAG) which can be accompanied by antinociceptive responses induced by morphine.
Positive_regulation (activation) of phospholipase Cgamma1 in PAG associated with urological neuroanatomy, antinociceptive, central grey and morphine
5) Confidence 0.27 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.40 Pain Relevance 0.59
Furthermore, morphine also caused a robust increase in the number of phosphorylated-PLC gamma 1 (p-PLC gamma 1) expressing cells in the PAG.
Positive_regulation (increase) of PLC gamma 1 in PAG associated with urological neuroanatomy and morphine
6) Confidence 0.24 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.26 Pain Relevance 1.43
Furthermore, morphine also caused a robust increase in the number of phosphorylated-PLC gamma 1 (p-PLC gamma 1) expressing cells in the PAG.
Positive_regulation (increase) of PLC gamma 1 in PAG associated with urological neuroanatomy and morphine
7) Confidence 0.21 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.26 Pain Relevance 1.44
Treatment s.c. with morphine produced a robust increase in the number of phosphorylated-PLCgamma1 (p-PLCgamma1) expressing cells in the PAG.
Positive_regulation (increase) of PLCgamma1 in PAG associated with urological neuroanatomy and morphine
8) Confidence 0.21 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.49 Pain Relevance 1.02
These findings suggest that in vivo morphine treatment can activate PLCgamma1 isoform in the mouse PAG which can be, at least in part, associated with the expression of supraspinal antinociception induced by mu-opioid receptor agonists in the mouse.
Positive_regulation (activate) of PLCgamma1 in PAG associated with antinociception, agonist, urological neuroanatomy, opioid receptor and morphine
9) Confidence 0.21 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.44 Pain Relevance 1.21
Treatment s.c. with morphine produced a robust increase in the number of phosphorylated-PLCgamma1 (p-PLCgamma1) expressing cells in the PAG.
Positive_regulation (increase) of PLCgamma1 in PAG associated with urological neuroanatomy and morphine
10) Confidence 0.21 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.49 Pain Relevance 1.03
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain.
Positive_regulation (induce) of phospholipase-Cgamma in brain associated with antidepressant
11) Confidence 0.05 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.54

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