INT96263

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 3 93.52 High High
agonist 4 90.60 High High
Enkephalin 2 89.28 High High
MU agonist 2 75.00 Quite High
aspirin 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 14 90.48 High High
Aging 12 85.92 High High
Diabetes Mellitus 4 69.36 Quite High
Stress 54 50.00 Quite Low
Hypoxia 20 38.04 Quite Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Cardiovascular Disease 10 5.00 Very Low Very Low Very Low
Nicotine Addiction 8 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Coronary Artery Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that (1) The abundance of mu- and delta- receptor mRNA decreased significantly up to 48h after the administration of DAMGO and DPDPE, respectively; whereas the inhibitory effect of OMF and BW373U86 lasted only for 24h; (2) DAMGO and DPDPE produced a significant decrease of the mRNA coding for mu-receptor and delta-receptor at concentrations as low as 10(-8) mol/L and 10(-6) mol/L, respectively, whereas OMF and BW373U86 were effective at concentrations one order of magnitude higher, respectively.
Positive_regulation (decreased) of Transcription (abundance) of delta
1) Confidence 0.49 Published 2001 Journal Life Sci. Section Abstract Doc Link 11400915 Disease Relevance 0 Pain Relevance 0.51
In this study, we also found genes sharing regulatory motifs for another transcription factor controlling mitochondrial gene transcription, Yin Yang 1 (YY1) [48], to be upregulated in both intervention groups.
Positive_regulation (upregulated) of Transcription (transcription) of Yin Yang 1
2) Confidence 0.18 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.38 Pain Relevance 0
In this study, we also found genes sharing regulatory motifs for another transcription factor controlling mitochondrial gene transcription, Yin Yang 1 (YY1) [48], to be upregulated in both intervention groups.
Positive_regulation (upregulated) of Transcription (transcription) of YY1
3) Confidence 0.18 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.38 Pain Relevance 0

General Comments

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