INT96269

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 71
Total Number 71
Disease Relevance 52.38
Pain Relevance 20.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
monocyte 3
lung 3
eyes 3
mast cell 3
Kupffer cell 2
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1592 100.00 Very High Very High Very High
cytokine 730 100.00 Very High Very High Very High
chemokine 454 100.00 Very High Very High Very High
Morphine 234 99.84 Very High Very High Very High
agonist 115 99.72 Very High Very High Very High
Multiple sclerosis 15 99.42 Very High Very High Very High
Central nervous system 106 98.60 Very High Very High Very High
ischemia 96 98.00 Very High Very High Very High
Inflammatory response 242 97.90 Very High Very High Very High
cINOD 94 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1813 100.00 Very High Very High Very High
Disease 694 100.00 Very High Very High Very High
Pulmonary Disease 160 100.00 Very High Very High Very High
Uveitis 86 100.00 Very High Very High Very High
Acute-phase Reaction 2 99.96 Very High Very High Very High
Lymphedema 90 99.92 Very High Very High Very High
Recurrence 11 99.82 Very High Very High Very High
Targeted Disruption 485 99.58 Very High Very High Very High
Demyelinating Disease 11 99.42 Very High Very High Very High
Atherosclerosis 456 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The facilitating actions of ginsenoside Rb1 on burn wound healing may be due to the increase in histamine production via the increase in mast cell migration to the burn wound area induced by the rapid elevation of MCP-1.


Positive_regulation (elevation) of MCP-1 in mast cell
1) Confidence 0.61 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18329832 Disease Relevance 0.30 Pain Relevance 0
Twenty-four hours after LPS-injection, the average level of MCP-1 in the RPE-choroid complex of the EIU animals was upregulated (519.0±57.3 pg/mg, n=8, p<0.01) compared with that of the controls (8.6±2 pg/mg, n=4; Figure 4A).
Positive_regulation (upregulated) of MCP-1 in choroid associated with uveitis
2) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.82 Pain Relevance 0.09
MCP-1 is an important mediator of monocyte infiltration [36], which is upregulated during EIU [35,37,38].
Positive_regulation (upregulated) of MCP-1 in monocyte associated with uveitis
3) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.14 Pain Relevance 0.44
IL-1b was increased at 1 h, whereas IL-6, MIP-2, and MCP-1 were increased by 4-8 h.
Positive_regulation (increased) of MCP-1
4) Confidence 0.47 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12883092 Disease Relevance 0.26 Pain Relevance 0.95
and DKO mice exposed to asbestos showed increased levels of MCP-1 (p < 0.01), G-CSF (p < 0.001), IL-5 (p < 0.01), IL-4 (p < 0.05), KC (p < 0.05), and IL-6 (p < 0.001) in BALF (Figure 5A).
Positive_regulation (stos show) of MCP-1 associated with targeted disruption
5) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.42 Pain Relevance 0.32
Because elevated levels of MCP-1 are known to occur in BALF after inhalation of chrysotile asbestos in C57BL/6 mice (Haegens et al. 2007), neutrophils elaborating MCP-1 may enter the systemic circulation.
Positive_regulation (elevated) of MCP-1 in neutrophils
6) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.82 Pain Relevance 0.23
After 9 days of asbestos exposure, which has previously been shown to be the time point of the maximum inflammatory response in lung after inhalation of chrysotile asbestos fibers (Haegens et al. 2007; Sabo-Attwood et al. 2005), MCP-1 in BALF remained elevated, with ApoE?
Positive_regulation (elevated) of MCP-1 in lung associated with inflammatory response
7) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.70 Pain Relevance 0.24
However, mRNA levels for MCP-1 were increased fivefold following 15 weeks of treatment with Celecoxib in comparison to non-treated control mice.
Positive_regulation (increased) of MCP-1
8) Confidence 0.34 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 14522423 Disease Relevance 0.05 Pain Relevance 0
and MCP-1 transcript levels were elevated at 3 months of age in 3xTg-AD mouse entorhinal cortex, and were increased to statistical significance by 6 months of age suggesting a state of chronic up-regulation and positive-feedback for the expression of both of these inflammatory molecules.
Positive_regulation (increased) of MCP-1 transcript in cortex associated with inflammation and disease
9) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.56 Pain Relevance 0.17
and MCP-1 transcript levels were elevated at 3 months of age in 3xTg-AD mouse entorhinal cortex, and were increased to statistical significance by 6 months of age suggesting a state of chronic up-regulation and positive-feedback for the expression of both of these inflammatory molecules.
Positive_regulation (elevated) of MCP-1 transcript in cortex associated with inflammation and disease
10) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.56 Pain Relevance 0.17
Differential strain responses in inflammation were positively associated with elevated levels of the chemokines KC and MCP-1, higher NF?
Positive_regulation (elevated) of MCP-1 associated with chemokine, inflammation and sprains and strains
11) Confidence 0.30 Published 2010 Journal Part Fibre Toxicol Section Abstract Doc Link PMC2861012 Disease Relevance 1.47 Pain Relevance 0.32
Further, we demonstrate a positive relationship between tumor promotion and susceptibility to V2O5-induced inflammation, involving the induction of the chemokines KC and MCP-1, the transcription factors NF?
Positive_regulation (induction) of MCP-1 associated with chemokine, inflammation and cancer
12) Confidence 0.30 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 0.92 Pain Relevance 0.18
MCP-1 was highly induced in A/J and BALB mice and expression coincided with the influx of both monocytes and lymphocytes into pulmonary tissue.
Positive_regulation (induced) of MCP-1 in lymphocytes
13) Confidence 0.30 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 0.67 Pain Relevance 0.28
There was a significant increase in the concentration of MCP-1 during and after carotid endarterectomy compared with before clamping of the artery.
Positive_regulation (increase) of MCP-1 in artery
14) Confidence 0.29 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.77 Pain Relevance 0.29
MCP-1 levels, too, were elevated in untreated mice with lymphedema and were further increased by NSAID and sTNF-R1 therapy (P<0.04).
Positive_regulation (elevated) of MCP-1 associated with cinod and lymphedema
15) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.69 Pain Relevance 0.79
KEY FINDINGS: Acute stress significantly increased CPP, proteolytic and trypsin activities, and MMCP-1 levels.
Positive_regulation (increased) of MMCP-1
16) Confidence 0.28 Published 2009 Journal Life Sci. Section Body Doc Link 19345697 Disease Relevance 0.07 Pain Relevance 0
KC increased 3-fold and MCP-1 by 2.5-fold at 6 hr and remained elevated in A/J mice at 1 day following the last V2O5 dose (Fig. 4A, C; P < 0.05).
Positive_regulation (increased) of MCP-1
17) Confidence 0.26 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 1.08 Pain Relevance 0.30
Significant increases in cytokines, such as interleukin (IL)-1beta, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF), and in chemokines, such as macrophage chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1 (MIP-1alpha) and Kupffer cell derived chemokine (KC), were detected, with no changes in T-cell-derived cytokines.
Positive_regulation (increases) of MCP-1 in Kupffer cell associated with chemokine, inflammation and cytokine
18) Confidence 0.25 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.54 Pain Relevance 0.67
Finally, CNS-infiltrating mononuclear cells from IL-4-treated mice produced lower levels of MCP-1 mRNA compared with control mice.
Positive_regulation (levels) of MCP-1 mRNA in CNS associated with central nervous system
19) Confidence 0.24 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11402297 Disease Relevance 1.52 Pain Relevance 0.68
MCP-1 levels, too, were elevated in untreated mice with lymphedema and were further increased by NSAID and sTNF-R1 therapy (P<0.04).
Positive_regulation (elevated) of MCP-1 associated with cinod and lymphedema
20) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.69 Pain Relevance 0.79

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