INT96271

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 21.34
Pain Relevance 11.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
astrocyte 6
macrophages 4
monocytes 4
neutrophil 4
aorta 2
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 485 100.00 Very High Very High Very High
cytokine 464 100.00 Very High Very High Very High
chemokine 188 100.00 Very High Very High Very High
Morphine 158 100.00 Very High Very High Very High
metalloproteinase 43 100.00 Very High Very High Very High
Paracetamol 34 100.00 Very High Very High Very High
Inflammatory mediators 26 100.00 Very High Very High Very High
Central nervous system 67 98.90 Very High Very High Very High
rheumatoid arthritis 59 97.84 Very High Very High Very High
Inflammatory response 68 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 554 100.00 Very High Very High Very High
Cancer 113 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Inflammatory Bowel Disease 100 99.28 Very High Very High Very High
Infection 161 99.16 Very High Very High Very High
Hepatotoxicity 10 99.04 Very High Very High Very High
Central Nervous System Disease 7 98.90 Very High Very High Very High
Syndrome 21 98.52 Very High Very High Very High
Sepsis 7 98.24 Very High Very High Very High
Disease 230 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that hepatic expression of CCR2 and MCP-1 was increased 10-fold and 20-fold, respectively, 12 to 72 hours after administration of acetaminophen to wild-type mice.
Positive_regulation (increased) of Gene_expression (expression) of MCP-1 associated with paracetamol
1) Confidence 0.53 Published 2002 Journal Hepatology Section Abstract Doc Link 11981759 Disease Relevance 0.44 Pain Relevance 0.51
B (oxidant-induced transcription factors associated with inflammation) are found in the promoter region of the MCP-1 gene, and their cooperative action is important in the induction of MCP-1 gene expression (Martin et al. 1997).
Positive_regulation (induction) of Gene_expression (expression) of MCP-1 associated with inflammation
2) Confidence 0.44 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.50 Pain Relevance 0.07
Since changes were not observed in APP processing, the authors concluded that MCP-1 overexpression in APPswe mice correlated with diminished clearance of A?
Positive_regulation (overexpression) of Gene_expression (overexpression) of MCP-1
3) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.53 Pain Relevance 0.11
Finally, CNS-infiltrating mononuclear cells from IL-4-treated mice produced lower levels of MCP-1 mRNA compared with control mice.
Positive_regulation (levels) of Gene_expression (produced) of MCP-1 mRNA in CNS associated with central nervous system
4) Confidence 0.24 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11402297 Disease Relevance 1.58 Pain Relevance 0.70
Expression of macrophage chemotactic protein-1 (MCP-1), KC/gro, interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9), and connective tissue growth factor (CTGF), inflammatory mediators known to participate in tissue repair, as well as the anti-inflammatory cytokine, interleukin-10 (IL-10), also increased in the liver following acetaminophen administration.
Positive_regulation (increased) of Gene_expression (Expression) of MCP-1 in connective tissue associated with paracetamol, inflammatory mediators, inflammation, metalloproteinase and cytokine
5) Confidence 0.24 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 1.11 Pain Relevance 0.83
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Positive_regulation (Acetaminophen-induced) of Gene_expression (expression) of MCP-1 associated with paracetamol
6) Confidence 0.24 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.90 Pain Relevance 0.84
The lack of a positive correlation between radicals and these markers of inflammation, as well as between clinical parameters known to be associated with increased radical production, indicates that the possible hypoperfusion that occurs during carotid endarterectomy, and which is responsible for radical production, is not enhanced enough to cause cerebral inflammation, resulting in increased ICAM-1 and MCP-1 values.
Positive_regulation (increased) of Gene_expression (values) of MCP-1 associated with inflammation
7) Confidence 0.21 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.79 Pain Relevance 0.33
MCP-1 gene expression, as measured by mRNA levels, in aorta was increased by 6.0 fold in apoE?
Positive_regulation (increased) of Gene_expression (expression) of MCP-1 in aorta
8) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.67 Pain Relevance 0.05
Real-time PCR was performed for GATA-3, T-bet, MCP-1, HO-1, B1R and B2R expression using SYBR Green assay (Applied Biosystem).
Positive_regulation (performed) of Gene_expression (expression) of MCP-1
9) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.06 Pain Relevance 0.15
The pattern of chemokine expression is consistent with the delay in neutrophil recruitment to the footpad: T. maculosa venom stimulated an early production of IL-1beta, IL-6, and MCP-1, but was unable to induce an effective early TNF-alpha and KC release.
Neg (unable) Positive_regulation (stimulated) of Gene_expression (production) of MCP-1 in neutrophil associated with chemokine
10) Confidence 0.19 Published 2008 Journal Toxicon Section Abstract Doc Link 18586048 Disease Relevance 0.53 Pain Relevance 0.20
APAP administration also increased expression of the proinflammatory mediators, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha), macrophage chemotactic protein-1 (MCP-1), and KC/gro, and the anti-inflammatory cytokine, interleukin-10 (IL-10).
Positive_regulation (increased) of Gene_expression (expression) of MCP-1 in macrophage associated with necrosis, paracetamol, inflammation, cancer and cytokine
11) Confidence 0.19 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.30 Pain Relevance 0.97
Significant increases in cytokines, such as interleukin (IL)-1beta, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF), and in chemokines, such as macrophage chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1 (MIP-1alpha) and Kupffer cell derived chemokine (KC), were detected, with no changes in T-cell-derived cytokines.
Positive_regulation (increases) of Neg (no) Gene_expression (detected) of MCP-1 in Kupffer cell associated with chemokine, inflammation and cytokine
12) Confidence 0.18 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.57 Pain Relevance 0.72
The G allele of -2518 A>G MCP1 polymorphism [dbSNP: rs1024611] was found to increase MCP-1 expression [13].
Positive_regulation (increase) of Gene_expression (expression) of MCP-1
13) Confidence 0.16 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1634873 Disease Relevance 0.77 Pain Relevance 0.34
Thus, our findings indicate that pulmonary exposure to carbon nano particles may induce MCP-1 expression in the airways.
Spec (may) Positive_regulation (induce) of Gene_expression (expression) of MCP-1
14) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.60 Pain Relevance 0.37
The pattern of chemokine expression is consistent with the delay in neutrophil recruitment to the footpad: T. maculosa venom stimulated an early production of IL-1beta, IL-6, and MCP-1, but was unable to induce an effective early TNF-alpha and KC release.
Neg (unable) Positive_regulation (stimulated) of Gene_expression (production) of MCP-1 in neutrophil associated with chemokine
15) Confidence 0.13 Published 2008 Journal Toxicon Section Abstract Doc Link 18586048 Disease Relevance 0.53 Pain Relevance 0.20
which subsequently participates in the amplification of the astrocyte inflammatory cascade by stimulating MCP-1 production [16], [45].
Positive_regulation (stimulating) of Gene_expression (production) of MCP-1 in astrocyte associated with inflammation
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.10 Pain Relevance 0.31
RESULTS: Indomethacin induced small intestinal damage with an increase in expression of TNF-alpha and MCP-1 in both rats and mice.
Positive_regulation (increase) of Gene_expression (expression) of MCP-1
17) Confidence 0.12 Published 2008 Journal Gut Section Body Doc Link 17639086 Disease Relevance 0.07 Pain Relevance 0
Specifically, in a murine model of Listeria monocytogenes infection, the initial recruitment of macrophages was caused by MyD88-independent production of MCP-1.
Neg (independent) Positive_regulation (independent) of Gene_expression (production) of MCP-1 in macrophages associated with infection
18) Confidence 0.12 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.56 Pain Relevance 0.27
, but enhanced the production of MCP-1 (Fig. 4).
Positive_regulation (enhanced) of Gene_expression (production) of MCP-1
19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.14 Pain Relevance 0.08
Moreover, the expression of IP-10 and MCP-1 genes in KT5, an astrocyte cell line, was induced in vitro upon stimulation with a crude antigen of malaria parasites [12].
Positive_regulation (induced) of Gene_expression (expression) of MCP-1 in astrocyte associated with malaria
20) Confidence 0.09 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.27 Pain Relevance 0.30

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