INT96273

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.27
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TAP1) mitochondrion (TAP1) endoplasmic reticulum (TAP1)
ATPase activity (TAP1) plasma membrane (TAP1) transmembrane transport (TAP1)
TAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 26 99.56 Very High Very High Very High
Arthritis 178 99.14 Very High Very High Very High
psoriasis 102 98.40 Very High Very High Very High
rheumatoid arthritis 22 13.60 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 22 99.56 Very High Very High Very High
Seronegative Spondarthritis 146 99.14 Very High Very High Very High
Psoriasis 102 98.40 Very High Very High Very High
Autoimmune Disease 4 93.52 High High
Necrosis 6 55.24 Quite High
Cancer 6 54.88 Quite High
Disease 24 30.88 Quite Low
Rheumatoid Arthritis 22 13.60 Low Low
Arthritis 40 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the allele and genotype analysis, the results indicated that TAP1 site 1910 allele G, genotype AG and TAP2 site 1693 genotype AA were associated with increased AS risk in a case-B27 negative control (p < 0.05).
TAP1 Binding (associated) of associated with spinal inflammation
1) Confidence 0.37 Published 2009 Journal Hum. Immunol. Section Abstract Doc Link 19480848 Disease Relevance 0.89 Pain Relevance 0.73
In this study, we investigated the association of TAP1 and TAP2 polymorphisms in genetically homogenous Chinese AS patients.
TAP1 Binding (association) of associated with spinal inflammation
2) Confidence 0.37 Published 2009 Journal Hum. Immunol. Section Abstract Doc Link 19480848 Disease Relevance 0.79 Pain Relevance 0.61
No association between low molecular protein (LMP) 2 or 7 polymorphisms [41] and PsA has been detected, whilst the transporter associated with antigen processing 1 (TAP1) *0101 allele has been associated with psoriasis but not with PsA [42].


TAP1 Binding (associated) of associated with psoriasis and arthritis
3) Confidence 0.33 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.24 Pain Relevance 0.57
No association between low molecular protein (LMP) 2 or 7 polymorphisms [41] and PsA has been detected, whilst the transporter associated with antigen processing 1 (TAP1) *0101 allele has been associated with psoriasis but not with PsA [42].


antigen processing 1 Binding (associated) of associated with psoriasis and arthritis
4) Confidence 0.33 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.24 Pain Relevance 0.57
[Study on the association of transporter associated with antigen processing gene with ankylosing spondylitis and HLA-B27 in Han nationality].
antigen processing Binding (associated) of associated with spinal inflammation
5) Confidence 0.00 Published 2001 Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi Section Title Doc Link 11402452 Disease Relevance 0.10 Pain Relevance 0.19

General Comments

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