INT96281

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav3) plasma membrane organization (Cav3) plasma membrane (Cav3)
enzyme binding (Cav3) protein complex (Cav3) cytoplasm (Cav3)
Anatomy Link Frequency
skeletal muscle 1
Cav3 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 4 97.20 Very High Very High Very High
Action potential 2 90.52 High High
tetrodotoxin 3 89.00 High High
antagonist 2 88.28 High High
Calcium channel 2 77.44 Quite High
GABAergic 1 50.88 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Structural Myopathies 17 50.00 Quite Low
Muscle Weakness 4 11.92 Low Low
Frailty 2 10.32 Low Low
Cytomegalovirus Infection 13 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Muscle Disease 5 5.00 Very Low Very Low Very Low
Charcot Marie Tooth Disease 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No evidence was found for involvement of Cav1/alpha1C and alpha1D (L-type), Cav2.2/alpha1B (N-type) or Cav2.3/alpha1E (R-type) high-voltage-activated VDCCs or low-voltage-activated Cav3/alpha1G, alpha1H and alpha1I (T-type) VDCCs in mediating presynaptic GABA release.
Positive_regulation (low-voltage-activated) of Cav3 associated with gaba
1) Confidence 0.49 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11403683 Disease Relevance 0 Pain Relevance 0.58
Our results indicate that when highly overexpressed in skeletal muscle, myotubularin alters membrane homeostasis leading to the formation of packed membrane assemblies close to the sarcolemma and of vacuoles that are positive for dystrophin, caveolin-3 and DHPR?
Positive_regulation (positive) of caveolin-3 in skeletal muscle
2) Confidence 0.16 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0

General Comments

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