INT96296

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.32
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1) signal transducer activity (Oprm1)
Oprm1 (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
opioid receptor 5 100.00 Very High Very High Very High
mu opioid receptor 7 99.12 Very High Very High Very High
Opioid 6 96.12 Very High Very High Very High
Antinociceptive 4 95.44 Very High Very High Very High
tolerance 4 94.80 High High
Analgesic 4 85.00 Quite High
antagonist 2 84.00 Quite High
narcan 2 83.12 Quite High
Spinal cord 1 79.16 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 99.28 Very High Very High Very High
Movement Disorders 2 86.68 High High
Hyperkinesis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.
mu-opioid receptor Negative_regulation (inhibition) of cyclase associated with bordatella infection and opioid receptor
1) Confidence 0.05 Published 2008 Journal Neuropharmacology Section Title Doc Link 18384820 Disease Relevance 0.17 Pain Relevance 0.90
In agreement with a lack of desensitization of mu-opioid receptors, 3 hr of continuous exposure of the cloned mu receptor to endomorphin-1 did not diminish the subsequent ability of the agonist to inhibit adenylate cyclase activity in cells expressing the cloned mu-opioid receptor.
mu receptor Negative_regulation (inhibit) of cyclase associated with agonist, mu opioid receptor and opioid receptor
2) Confidence 0.02 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404430 Disease Relevance 0.15 Pain Relevance 0.75

General Comments

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