INT96299

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 35
Total Number 37
Disease Relevance 15.67
Pain Relevance 16.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
microglia 10
neurons 10
brain 6
internal 4
dorsal horns 4
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 485 100.00 Very High Very High Very High
qutenza 72 100.00 Very High Very High Very High
Dorsal horn 51 100.00 Very High Very High Very High
long-term potentiation 115 99.88 Very High Very High Very High
Spinal cord 207 99.84 Very High Very High Very High
nMDA receptor 30 99.84 Very High Very High Very High
antidepressant 45 99.60 Very High Very High Very High
tetrodotoxin 10 99.60 Very High Very High Very High
Dopamine 21 99.56 Very High Very High Very High
Stimulus evoked pain 58 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 80 100.00 Very High Very High Very High
Stress 49 100.00 Very High Very High Very High
Hypoxia 36 99.98 Very High Very High Very High
Nociception 33 99.66 Very High Very High Very High
Pain 197 99.32 Very High Very High Very High
Neuropathic Pain 264 99.24 Very High Very High Very High
Hypersensitivity 70 99.12 Very High Very High Very High
Nervous System Injury 80 99.10 Very High Very High Very High
Injury 110 99.00 Very High Very High Very High
Disease 24 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the amount of BDNF released by burst stimulation was increased after NGF treatment.
Positive_regulation (increased) of Localization (released) of BDNF
1) Confidence 0.70 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.88
However, it is unknown whether or not oxidative stress actually increases availability of BDNF by stimulating BDNF secretion.
Spec (whether) Positive_regulation (stimulating) of Localization (secretion) of BDNF associated with stress
2) Confidence 0.67 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.64 Pain Relevance 0.10
This upregulated BDNF content in the DRG and increased the capsaicin-evoked release of BDNF.
Positive_regulation (increased) of Localization (release) of BDNF in DRG associated with qutenza
3) Confidence 0.61 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.90
Each stimulation protocol resulted in a significant increase in BDNF release that was tetrodotoxin sensitive and occurred in the absence of glutamate receptor activation.
Positive_regulation (increase) of Localization (release) of BDNF associated with tetrodotoxin and glutamate receptor
4) Confidence 0.60 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.09 Pain Relevance 0.30
IH-induced BDNF release requires activation of tetrodotoxin sensitive Na+ channels and Ca2+ influx through N- and L-type channels, as well as mobilization of internal Ca2+ stores.
Positive_regulation (induced) of Localization (release) of BDNF in internal associated with tetrodotoxin and hypoxia
5) Confidence 0.58 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.77 Pain Relevance 0.23
BDNF secretion from neuronally differentiated PC12 cells was strongly stimulated by exposure to intermittent hypoxia (IH).
Positive_regulation (stimulated) of Localization (secretion) of BDNF associated with hypoxia
6) Confidence 0.58 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.76 Pain Relevance 0.12
These experiments demonstrate that BDNF release in the dorsal horn is encoded by specific patterns of afferent fiber stimulation and is mediated by NMDA receptor activation.
Positive_regulation (mediated) of Localization (release) of BDNF in dorsal horn associated with nmda receptor and dorsal horn
7) Confidence 0.50 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.72
Visualization of Htt, Ago2 with BDNF mRNA
Positive_regulation (with) of Localization (Visualization) of BDNF
8) Confidence 0.48 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.05
These data indicate that oxidative stress can stimulate BDNF release through an autocrine or paracrine loop that requires dopamine receptor activation.
Positive_regulation (stimulate) of Localization (release) of BDNF associated with stress and dopamine receptor
9) Confidence 0.45 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.75 Pain Relevance 0.31
As shown in Figure 2, the upregulated BDNF was mainly localized in the neurons and the primary nerve terminals in the superficial layers and the deep layers of the dorsal horns (Figure 2B).
Positive_regulation (upregulated) of Localization (localized) of BDNF in dorsal horns associated with bdmf
10) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0 Pain Relevance 0.84
In attempt to confirm the localization of the upregulated BDNF, double immunofluorescence was performed.
Positive_regulation (upregulated) of Localization (localization) of BDNF associated with bdmf
11) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0 Pain Relevance 0.87
It is known that BDNF enhances the local translation of different glutamate receptor subunits, particularly the GluR1 subunit of AMPA receptor [47]–[49] through activation of mTOR [48] and that BDNF is stored in and released from glutamatergic hippocampal neurons [50].
Positive_regulation (activation) of Localization (released) of BDNF in neurons associated with glutamate receptor
12) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.15
stimulation inducing LTP evokes significant increases in BDNF mRNA expression [41–44] and BDNF release [45] in the
Positive_regulation (increases) of Localization (release) of BDNF associated with long-term potentiation
13) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.14 Pain Relevance 0.39
It is possible that in our model, all the neovascularization events taking place may stimulate BDNF synthesis and release.
Spec (may) Positive_regulation (stimulate) of Localization (release) of BDNF
14) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 1.50 Pain Relevance 0.04
Previously, increased expression and secretion of brain-derived neurotrophic factor (BDNF) had been implicated in injury-induced neuropathic pain in the sensory system.
Positive_regulation (increased) of Localization (secretion) of BDNF in sensory system associated with injury and neuropathic pain
15) Confidence 0.41 Published 2006 Journal Neurotox Res Section Abstract Doc Link 16782586 Disease Relevance 0.55 Pain Relevance 0.38
Capsaicin superfusion (1-100 microm) induced a dose-dependent release of BDNF, measured using ELISA.
Positive_regulation (induced) of Localization (release) of BDNF associated with qutenza
16) Confidence 0.41 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.71
IH-induced BDNF release requires activation of tetrodotoxin sensitive Na+ channels and Ca2+ influx through N- and L-type channels, as well as mobilization of internal Ca2+ stores.
Positive_regulation (requires) of Localization (release) of BDNF in internal associated with tetrodotoxin and hypoxia
17) Confidence 0.39 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.77 Pain Relevance 0.23
These results demonstrate that oxidative stress can stimulate BDNF release and that underlying mechanisms are similar to those previously described for activity-dependent BDNF secretion from neurons.
Positive_regulation (stimulate) of Localization (release) of BDNF in neurons associated with stress
18) Confidence 0.39 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.74 Pain Relevance 0.29
Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling.
Positive_regulation (requires) of Localization (Secretion) of brain-derived neurotrophic factor in brain associated with stress and dopamine
19) Confidence 0.39 Published 2006 Journal J. Neurochem. Section Title Doc Link 16390493 Disease Relevance 0.70 Pain Relevance 0.20
For example, BDNF which is injected into the retina can be internalized by retinal ganglion neurons and transported into the superior colliculus, released and transferred to the postsynaptic neurons[15].
Positive_regulation (transferred) of Localization (released) of BDNF in neurons associated with ganglion cysts and bdmf
20) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.36 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox